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Sent on Thursday, 2009 Apr 02Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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| PubMed Results |
- 1: J Antimicrob Chemother. 2009 Mar 31. [Epub ahead of print]
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Evaluation of anti-sleeping-sickness drugs and topoisomerase inhibitors in combination on Trypanosoma brucei.
BioMedical Research Centre, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK.
PMID: 19336455 [PubMed - as supplied by publisher]
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Related Articles
- Anti-trypanosomal activities of DNA topoisomerase inhibitors. [Acta Trop. 2005]
- ReviewThe challenge of Trypanosoma brucei gambiense sleeping sickness diagnosis outside Africa. [Lancet Infect Dis. 2003]
- Improved trypanocidal activities of cathepsin L inhibitors. [Int J Antimicrob Agents. 2003]
- ReviewChemotherapeutic strategies against Trypanosoma brucei: drug targets vs. drug targeting. [Curr Pharm Des. 2007]
- The origins of a new Trypanosoma brucei rhodesiense sleeping sickness outbreak in eastern Uganda. [Lancet. 2001]
- 2: Ann R Coll Surg Engl. 2009 Apr;91(3):1-2.
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Diagnostic splenectomy for visceral leishmaniasis.
Department of General Surgery, Musgrove Park Hospital, Taunton, UK.
A 57-year-old-man with a history of malaise, fever, night sweats and shortness of breath presented a diagnostic challenge to his medical team. He was pancytopaenic and had splenomegaly on admission but other investigations, including bone marrow aspiration, proved inconclusive. After the patient deteriorated clinically, the general surgical team was requested to perform a diagnostic splenectomy. The histology of this showed infection with visceral leishmaniasis. He recovered completely with Amphotericin treatment. Although this is a rare condition, particularly for the general surgeon, this case highlights the difficult position surgeons are often put in when performing major surgery diagnostically.
PMID: 19335964 [PubMed - in process]
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Related Articles
- [Fever, pancytopenia, and splenomegaly 8 months after a trip to Majorca Island (Spain)] [Med Klin (Munich). 2008]
- A renal transplant recipient with pulmonary tuberculosis and visceral leishmaniasis: review of superimposed infections and therapy approaches. [Clin Nephrol. 2003]
- [HIV positive patient with pancytopenia and massive splenomegaly] [Internist (Berl). 2003]
- ReviewVisceral leishmaniasis (Kala-Azar) in transplant recipients: case report and review. [Transplantation. 1998]
- Review[A case of visceral leishmaniasis] [Rev Invest Clin. 1997]
- 3: J Travel Med. 2009 Mar-Apr;16(2):144-5.
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Imported leishmaniasis in australia.
Parasite Ecology Section, Tropical Medicine Institute, Universidad Central de Venezuela, Caracas, Venezuela.
PMID: 19335819 [PubMed - in process]
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Related Articles
- Leishmaniasis, an emerging imported infection: report of 20 cases from Australia. [J Travel Med. 2008]
- New World cutaneous leishmaniasis imported into Australia. [Pathology. 1998]
- Cutaneous leishmaniasis imported from Colombia to Northcentral Venezuela: implications for travel advice. [Travel Med Infect Dis. 2008]
- Review[Parasite identification in the surveillance of imported leishmaniasis cases in Italy] [Parassitologia. 2004]
- ReviewCanine leishmaniasis. A review based on 95 cases in The Netherlands. [Vet Q. 1988]
- 4: J Travel Med. 2009 Mar-Apr;16(2):123-31.
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Treatment of cutaneous leishmaniasis in travelers 2009.
Medical Department, Swiss Tropical Institute, Basel, Switzerland.
PMID: 19335813 [PubMed - in process]
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Related Articles
- American cutaneous leishmaniasis in U.S. travelers. [Ann Intern Med. 1993]
- South American cutaneous leishmaniasis: report of ten cases in Israeli travelers. [J Eur Acad Dermatol Venereol. 1998]
- Experience with New World cutaneous leishmaniasis in travelers. [J Am Acad Dermatol. 2003]
- ReviewCutaneous leishmaniasis in the returning traveler. [Infect Dis Clin North Am. 2005]
- ReviewImported tropical infectious ulcers in travelers. [Am J Clin Dermatol. 2008]
- 5: Int J Dermatol. 2009 Apr;48(4):441-3.
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Indigenous cutaneous leishmaniasis in Taiwan: three additional cases in southern Taiwan.
Tainan, Taiwan.
PMID: 19335438 [PubMed - in process]
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Related Articles
- Indigenous leishmaniasis in Taiwan: report of a case. [Int J Dermatol. 2008]
- Introduced leishmaniasis on Taiwan. [Southeast Asian J Trop Med Public Health. 1985]
- Autochthonous cutaneous-subcutaneous leishmaniasis on Taiwan. [Am J Trop Med Hyg. 1985]
- ReviewLeishmaniasis in the Caribbean Islands. A review. [Ann N Y Acad Sci. 1992]
- ReviewCutaneous leishmaniasis in Texas: report of a case and review of the literature. [J Am Acad Dermatol. 1990]
- 6: Int J Dermatol. 2009 Apr;48(4):404-8.
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A comparative study of the diagnosis of Old World cutaneous leishmaniasis in Iraq by polymerase chain reaction and microbiologic and histopathologic methods.
Departments of Microbiology and Dermatology, College of Medicine, University of Kufa, Kufa, Iraq.
Background The diagnosis of cutaneous leishmaniasis (CL) largely depends on the clinical appearance, especially in endemic areas. A diagnostic challenge arises when the lesions appear in nonendemic areas, when the clinical picture is distorted, or when an atypical variant is seen, even in endemic regions. Aim To assess the correlation of microbiologic and histopathologic diagnosis with polymerase chain reaction (PCR) findings in clinically diagnosed cases of CL. Methods This was an observational and descriptive study. The patients were seen at outpatient departments of dermatology in the middle Euphrates region of Iraq. Sixty-five patients with clinically suspicious CL lesions were screened. Fifty-seven clinically diagnosed cases were then subjected to slit-skin smear and skin biopsy. PCR examination was conducted in 40 cases. Results Direct slit-skin smear examination was positive in 38 patients (66.7%), and 48 specimens (84.2%) were positive by the slide-touch skin biopsy method. Histopathologic examination showed features suggestive of CL in 34 specimens (59.6%). The results of PCR examination were positive in 37 cases (92.5%). Conclusion The PCR technique is highly specific (100%) and sensitive (92.5%) for the diagnosis of CL. In addition to the confirmation of the diagnosis, it may be useful in identifying a relationship between the type of microorganism and the clinical presentation of the disease.
PMID: 19335428 [PubMed - in process]
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Related Articles
- Correlation of clinical, histopathological, and microbiological findings in 60 cases of cutaneous leishmaniasis. [Indian J Dermatol Venereol Leprol. 2006]
- Polymerase chain reaction for diagnosis of cutaneous leishmaniasis in histologically positive, suspicious and negative skin biopsies. [Dermatology. 2002]
- Atypical presentation of Old-World cutaneous leishmaniasis, diagnosis and species identification by PCR. [J Eur Acad Dermatol Venereol. 2008]
- ReviewClinical use of polymerase chain reaction performed on peripheral blood and bone marrow samples for the diagnosis and monitoring of visceral leishmaniasis in HIV-infected and HIV-uninfected patients: a single-center, 8-year experience in Italy and review of the literature. [Clin Infect Dis. 2007]
- ReviewDiagnosis of cutaneous leishmaniasis. [Curr Opin Infect Dis. 2003]
- 7: Rev Esp Enferm Dig. 2009 Jan;101(1):60-62.
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Duodenal leishmaniasis in a HIV patient.
[Article in Spanish, English]PMID: 19335034 [PubMed - as supplied by publisher]
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Related Articles
- [Unusual presentation of visceral leishmaniasis in an immunocompetent patient] [Med Mal Infect. 2006]
- [Visceral leishmaniasis with duodenal involvement in an HIV patient] [Rev Esp Enferm Dig. 2001]
- Duodenal leishmaniasis diagnosed by biopsy in two HIV-positive patients. [Pathol Res Pract. 1997]
- Review[Multiple digestive involvement in visceral leishmaniasis in a patient with HIV infection: favourable course with itraconazole] [Rev Med Interne. 1996]
- ReviewLeishmaniases and HIV/AIDS co-infections: review of common features and management experiences. [Ethiop Med J. 2002]
- 8: RNA. 2009 Apr;15(4):648-65. Epub 2009 Feb 13.
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Multiple roles for polypyrimidine tract binding (PTB) proteins in trypanosome RNA metabolism.
Bar-Ilan University, Ramat-Gan, Israel.
Trypanosomatid genomes encode for numerous proteins containing an RNA recognition motif (RRM), but the function of most of these proteins in mRNA metabolism is currently unknown. Here, we report the function of two such proteins that we have named PTB1 and PTB2, which resemble the mammalian polypyrimidine tract binding proteins (PTB). RNAi silencing of these factors indicates that both are essential for life. PTB1 and PTB2 reside mostly in the nucleus, but are found in the cytoplasm, as well. Microarray analysis performed on PTB1 and PTB2 RNAi silenced cells indicates that each of these factors differentially affects the transcriptome, thus regulating a different subset of mRNAs. PTB1 and PTB2 substrates were categorized bioinformatically, based on the presence of PTB binding sites in their 5' and 3' flanking sequences. Both proteins were shown to regulate mRNA stability. Interestingly, PTB proteins are essential for trans-splicing of genes containing C-rich polypyrimidine tracts. PTB1, but not PTB2, also affects cis-splicing. The specificity of binding of PTB1 was established in vivo and in vitro using a model substrate. This study demonstrates for the first time that trans-splicing of only certain substrates requires specific factors such as PTB proteins for their splicing. The trypanosome PTB proteins, like their mammalian homologs, represent multivalent RNA binding proteins that regulate mRNAs from their synthesis to degradation.
PMID: 19218552 [PubMed - indexed for MEDLINE]
PMCID: PMC2661826 [Available on 2009/10/01]
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Related Articles
- Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB). [RNA. 2001]
- A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart. [RNA. 1997]
- The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression. [J Biol Chem. 2006]
- ReviewPolypyrimidine-tract-binding protein: a multifunctional RNA-binding protein. [Biochem Soc Trans. 2008]
- ReviewStructure-function relationships of the polypyrimidine tract binding protein. [Cell Mol Life Sci. 2008]
- 9: Acta Trop. 2009 Jan;109(1):78-80. Epub 2008 Sep 6.
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Trypanosoma cruzi congenital transmission in wild bats.
Investigaciones Parasitológicas J.F.Torrealba, Universidad de Los Andes, Facultad de Ciencias, Departamento de Biología, Mérida 5101, Venezuela. nanes@ula.ve
Trypanosoma cruzi congenital transmission in wild bats (Molossus molossus), associated with infected Rhodnius prolixus in a natural habitat from a rural locality in western Venezuela, is reported. T. cruzi blood circulating trypomastigotes in a pregnant bat were detected by parasitological methods. Polymerase chain reaction (PCR) assays carried out in samples from the heart and the fetus of the same infected female, revealed the presence of T. cruzi-specific DNA in both of the tissues, demonstrating transmission of the infection from the mother to the offspring. Eighty percent of the captured bats and 100% of the examined fetuses from pregnant specimens were shown to be infected by T. cruzi, indicating that M. molossus is a very susceptible species for this parasite, and that T. cruzi congenital transmission is a common phenomenon in nature. To our knowledge, this seems to be the first report on congenital T. cruzi transmission in wild bats in Venezuela. The circulation of T. cruzi lineage I in the study area was demonstrated by typing the isolates from bats and triatomine bugs captured in the same habitat. The potential epidemiological implication of these findings in areas where Chagas disease is endemic is discussed.
PMID: 18823929 [PubMed - indexed for MEDLINE]
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Related Articles
- Experimental transmission of the parasitic flagellates Trypanosoma cruzi and Trypanosoma rangeli between triatomine bugs or mice and captive neotropical bats. [Mem Inst Oswaldo Cruz. 2007]
- High prevalence of Trypanosoma rangeli and Trypanosoma cruzi in opossums and triatomids in a formerly-endemic area of Chagas disease in Southeast Brazil. [Acta Trop. 2002]
- Direct molecular profiling of minicircle signatures and lineages of Trypanosoma cruzi bloodstream populations causing congenital Chagas disease. [Int J Parasitol. 2007]
- Review[Detection of molecular heterogeneity of Trypanosoma cruzi] [Rev Soc Bras Med Trop. 2005]
- ReviewDetection of Trypanosoma cruzi with the polymerase chain reaction and in situ hybridization in infected murine cardiac tissue. [Am J Trop Med Hyg. 1997]
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