What's new for 'Trypanosomatids' in PubMed

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Sent on Friday, 2009 Jun 12
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results

Items 1 -2 of 2

1: J Clin Microbiol. 2009 Jun 10. [Epub ahead of print]

A Novel Noninvasive Method for Diagnosis of Visceral Leishmaniasis by rK39 Test in Sputum Samples.

Singh D, Pandey K, Das VN, Das S, Kumar S, Topno RK, Das P.

Department of Molecular Biology, Rajendra Memorial Research Institute of Medical Sciences (ICMR), Agamkuan, Patna, India-800 007; Department of Clinical Medicine, Rajendra Memorial Research Institute of Medical Sciences (ICMR), Agamkuan, Patna India-800 007; Department of Epidemiology, Rajendra Memorial Research Institute of Medical Sciences (ICMR), Agamkuan, Patna-800 007.

Visceral Leishmaniasis (VL) is a major public health problem of the eastern states in India namely Bihar, West Bengal, Jharkhand, and Eastern Uttar Pradesh. ...

PMID: 19515836 [PubMed - as supplied by publisher]

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2: J Cell Sci. 2009 Apr 15;122(Pt 8):1081-90. Epub 2009 Mar 19. LinkOut

Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography.

Lacomble S, Vaughan S, Gadelha C, Morphew MK, Shaw MK, McIntosh JR, Gull K.

Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

This study uses electron tomography linked to a variety of other EM methods to provide an integrated view of the flagellar pocket and basal body area of the African trypanosome procyclic trypomastigote. We reveal the pocket as an asymmetric membranous 'balloon' with two boundary structures. One of these - the collar - defines the flagellum exit point. The other defines the entry point of the flagellum into the pocket and consists of both an internal transitional fibre array and an external membrane collarette. A novel set of nine radial fibres is described in the basal body proximal zone. The pocket asymmetry is invariably correlated with the position of the probasal body and Golgi. The neck region, just distal to the flagellum exit site, is a specialised area of membrane associated with the start of the flagellum attachment zone and signifies the point where a special set of four microtubules, nucleated close to the basal bodies, joins the subpellicular array. The neck region is also associated with the single Golgi apparatus of the cell. The flagellar exit point interrupts the subpellicular microtubule array with discrete endings of microtubules at the posterior side. Overall, our studies reveal a highly organised, yet dynamic, area of cytoplasm and will be informative in understanding its function.

PMID: 19299460 [PubMed - indexed for MEDLINE]

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