What's new for 'Trypanosomatids' in PubMed

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Sent on Thursday, 2009 Aug 13
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results

Items 1 -2 of 2

1: Int J Dermatol. 2009 Aug;48(8):862-9.

Tropical medicine rounds: Treatment of Old World cutaneous leishmaniasis with dapsone, itraconazole, cryotherapy, and imiquimod, alone and in combination.

Al-Mutairi N, Alshiltawy M, El Khalawany M, Joshi A, Eassa BI, Manchanda Y, Gomaa S, Darwish I, Rijhwani M.

Department of Dermatology, Institutional Affiliation, Farwaniya Hospital, Kuwait. nalmut@usa.net

BACKGROUND: Cutaneous leishmaniasis (CL) is a major public health problem. The currently available therapies are expensive, not freely available, toxic, and not always curative. A simple, effective, noninvasive therapeutic approach is required for the treatment of CL.AIMS: To determine the clinical patterns of CL and to report our experience in the management of CL.METHODS: One hundred and ten patients with CL seen between January 2005 and December 2007 were included in this study. The diagnosis was based on clinical features, parasitologic diagnosis, histopathology, and culture. Each patient was treated according to disease severity with either topical (cryotherapy or imiquimod) or systemic (itraconazole or dapsone) monotherapy, or a combination of these modalities. RESULTS: CL was more common in adult expatriate men, with the upper limbs as the most commonly affected site. Noduloulcerative CL was the most common presentation (84.6%). Atypical CL was found in 18 patients. Skin biopsy was the most common diagnostic technique (66.6%). Monotherapy showed an overall success rate of 56.41%, whereas combination therapy was successful in 69.56% of cases. Cryotherapy alone was successful in 68.18% of cases. Imiquimod alone was ineffective. CONCLUSION: A stepwise approach represents a rational and practical way of confirming CL. A combination of itraconazole/dapsone and topically applied imiquimod is safe, simple, and effective for the treatment of CL. More studies are needed to establish the role of such an approach. Cryotherapy is also safe, simple and effective for the treatment of CL.

PMID: 19673049 [PubMed - in process]

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Patient Drug Information

• Itraconazole (Sporanox®)

  Itraconazole capsules are used to treat fungal infections that begin in the lungsand can spread through the body. Itraconazole capsules are also used to treat fungal infections of the fingernails and/or toenails. Itracon...

• Dapsone (available generically)

  Dapsone is used to treat leprosy and skin infections.

• Imiquimod Topical (Aldara®)

  Imiquimod cream is used to treat certain types of actinic keratoses (flat, scaly growths on the skin caused by too much sun exposure) on the face or scalp. Imiquimod cream is also used to treat superficial basal cell car...

• Source: AHFS Consumer Medication Information

2: Ceylon Med J. 2009 Jun;54(2):46-7.

A simple, cost effective method for isolation and transportation of Leishmania parasites.

Ihalamulla RL, Rajapaksa US, Siriwardena HV, Chance M, Karunaweera ND.

Department of Parasitology, Faculty of Medicine, Kynsey Road, Colombo 8, Sri Lanka.

Isolation and propagation of Leishmania parasites using conventional culture methods are difficult, especially under field conditions. Transportation of live parasites requires the maintenance of low temperatures, which increases the cost considerably. The present study demonstrates that monophasic micro capillary culture is a simpler, more economical and better alternative to using conventional Evan's modified Tobie's medium to isolate and transport the Leishmania parasite over long distances without the use of temperature control methods.

PMID: 19670547 [PubMed - in process]

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