Saturday, August 15, 2009

What's new for 'Trypanosomatids' in PubMed

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Sent on Saturday, 2009 Aug 15
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results
Items 1 -5 of 5

1: Biometals. 2009 Aug 13. [Epub ahead of print]Click here to read

Synthesis, characterization and evaluation of antileishmanial activity of copper(II) with fluorinated alpha-hydroxycarboxylate ligands.

da Silva Maffei R, Yokoyama-Yasunaka JK, Miguel DC, Uliana SR, Espósito BP.

Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, São Paulo, 05508-000, Brazil.

In this study, Cu(II) complexes with fluorinated ligands were produced aiming at the development of new, less toxic antileishmanial metallodrugs. Complexes of the general formula CuL(2) (L = lactate, trifluorolactate, 2-hydroxyisobutyrate, trifluoro-2-hydroxyisobutyrate) were synthesized in methanolic medium, purified by crystallization and characterized by elemental analysis and electronic and infrared spectroscopies. In vitro experiments with Leishmania amazonensis promastigotes showed that the trifluorolactate derivative more active than its non-fluorinated counterpart. Our results indicate that fluorinated chelators may be interesting to increase metal toxicity and/or open new paths for metallodrug chemotherapy against leishmaniasis.

PMID: 19680603 [PubMed - as supplied by publisher]

2: Exp Parasitol. 2009 Aug 10. [Epub ahead of print]Click here to read

Proteomic analysis of wild type and arsenite resistant Leishmania donovani.

Sharma S, Singh G, Chavan HD, Dey CS.

Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India.

Leishmania donovani, causative organism for visceral leishmaniasis, is responsible for considerable mortality and morbidity worldwide. Generation of drug resistant variants continue to challenge the chemotherapy, the mainstay to fight the disease. The aim of current study was proteomic profiling of wild type (Ld-Wt) and arsenite-resistant (Ld-As20) L. donovani. Significant differences in protein profiles were observed between Ld-As20 and its parent Ld-Wt strain. Proteomic analysis of 158 spots from Ld-Wt and 144 spots from, Ld-As20 identified 77 and 74 protein entries, respectively, through MALDI-TOF/TOF based mass spectrometry and database search. A shift in the isoelectric point of few proteins was observed both in Ld-Wt and Ld-As20, which raises the possibility of continuous arsenite stress, resulting in the differences in the protein profiles of drug resistant strain from its parent wild type strain. The comparative proteomic data holds the key for elucidation of the multifactorial and complex drug resistance mechanism, like arsenite resistance, in the parasite.

PMID: 19679130 [PubMed - as supplied by publisher]

3: J Altern Complement Med. 2009 Aug;15(8):815-6.Click here to read

The potential utility of green tea extract as a novel treatment for cutaneous leishmaniasis.

Feily A, Yaghoobi R, Namazi MR.

PMID: 19678770 [PubMed - in process]

4: Immunopharmacol Immunotoxicol. 2009 Aug 13. [Epub ahead of print]Click here to read

In vitro studies on the relationship between the anti-inflammatory activity of Physalis peruviana extracts and the phagocytic process.

Martínez W, Ospina LF, Granados D, Delgado G.

Immunotoxicology Research Group, Science Faculty, National University of Colombia, Bogotá, Colombia.

The study of plants used in traditional medicine has drawn the attention of researchers as an alternative in the development of new therapeutics agents, such as the American Solanaceae Physalis peruviana, which has significant anti-inflammatory activity. The Physalis peruviana anti-inflammatory effect of ethanol or ether calyces extracts on the phagocytic process was assessed by using an in vitro phagocytosis model (Leishmania panamensis infection to murine macrophages). The Physalis peruviana extracts do not inhibit microorganism internalization and have no parasiticide effect. Most ET and EP extracts negatively affected the parasite's invasion of macrophages (Infected cells increased.). This observation might result from a down-regulation of the macrophage's microbicide ability associated with a selective reduction of proinflammatory cytokines levels. Physalis peruviana's anti-inflammatory activity described in this model is related to an immunomodulatory effect exerted on macrophages infected, which directly or indirectly "blocks" their ability to secrete soluble proinflammatory mediators.

PMID: 19678736 [PubMed - as supplied by publisher]

5: Clin Infect Dis. 2009 Apr 15;48(8):1104-6.Click here to read LinkOut

Spatial patterns in discordant diagnostic test results for Chagas disease: links to transmission hotspots.

Levy MZ, Bowman NM, Kawai V, Plotkin JB, Waller LA, Cabrera L, Steurer F, Seitz AE, Pinedo-Cancino VV, Cornejo del Carpio JG, Cordova Benzaquen E, McKenzie FE, Maguire JH, Gilman RH, Bern C.

Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA. mzlevy@sas.upenn.edu

Diagnosis of Chagas disease is hindered by discordance between screening and confirmatory test results for Trypanosoma cruzi infection. In periurban Arequipa, Peru, spatial analysis revealed that individuals with discordant test results are spatially clustered in hotspots of T. cruzi transmission, suggesting that discordant results likely represent true infections in this setting.

PMID: 19278335 [PubMed - indexed for MEDLINE]

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