What's new for 'Trypanosomatids' in PubMed

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Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results

Items 1 -4 of 4

1: Lipids. 2009 Sep 30. [Epub ahead of print]

Total Synthesis and Antileishmanial Activity of the Natural Occurring Acetylenic Fatty Acids 6-Heptadecynoic Acid and 6-Icosynoic Acid.

Carballeira NM, Cartagena MM, Prada CF, Rubio CF, Balaña-Fouce R.

Department of Chemistry, University of Puerto Rico, P.O. Box 23346, San Juan, PR, 00931-3346, USA, nmcarballeira@uprrp.edu.

The first total syntheses of the naturally occurring acetylenic fatty acids-6-heptadecynoic acid (59% overall yield) and 6-icosynoic acid (34% overall yield)-was accomplished in four steps. Using the same synthetic sequence the naturally occurring fatty acids (6Z)-heptadecenoic acid (46% overall yield) and (6Z)-icosenoic acid (27% overall yield) were also synthesized. The Delta(6) acetylenic fatty acids displayed good antiprotozoal activity towards Leishmania donovani promastigotes (EC(50) = 1-6 microg/mL), but the 6-icosynoic acid was the most effective in the series. In addition, the (6Z)-icosenoic acid was a much better antiprotozoal compound (EC(50) = 5-6 microg/mL) than the (6Z)-heptadecenoic acid (EC(50) > 25 microg/mL). The saturated fatty acids n-heptadecanoic acid and n-eicosanoic acid were not effective towards L. donovani, indicating that the Delta(6) unsaturation in these fatty acids is necessary for leishmanicidal activity. In addition, both the 6-icosynoic acid and the (6Z)-icosenoic acid were inhibitors of the Leishmania DNA topoisomerase IB enzyme (EC(50's) = 36-49 microM), a possible intracellular target for these compounds. This is the first study assessing fatty acids as inhibitors of the Leishmania DNA topoisomerase IB enzyme.

PMID: 19789903 [PubMed - as supplied by publisher]

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• Potent in vitro antifungal activities of naturally occurring acetylenic acids.

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2: Genome Biol. 2009;10(6):223. Epub 2009 Jun 8. LinkOut

DNA breaks as triggers for antigenic variation in African trypanosomes.

Alsford S, Horn D, Glover L.

London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E7HT, UK.

The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.

PMID: 19519956 [PubMed - indexed for MEDLINE]

PMCID: PMC2718488 [Available on 2010/06/08]

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3: Epidemiol Infect. 2009 Nov;137(11):1583-5. Epub 2009 Apr 15. LinkOut

Detection of Trypanosoma evansi infection in clinically ill cattle, buffaloes and horses using various diagnostic tests.

Laha R, Sasmal NK.

West Bengal University of Animal and Fishery Sciences, Kolkata - 700037, West Bengal India.

This study was undertaken to detect Trypanosoma evansi infection in clinically ill cattle, buffaloes and horses that were suspected of 'surra' infection. Various diagnostic tests were utilized in order to assess the prevalence of infection in the clinically ill and 'suspected' animals. Animals in the Eastern Region of India were systematically studied for T. evansi infection, which had not been tested for previously. Examination of Giemsa-stained blood smears detected 5.3%, 9.4% and 40.6% infections; the mouse inoculation test detected 18.4%, 15.6% and 46.9% infections whereas an in-house ELISA detected anti-trypanosomal antibodies in 42.1%, 43.8% and 65.6% infections in clinically ill buffaloes, cattle and horses, respectively. It can be concluded that T. evansi is prevalent in cattle, buffaloes and horses in the Eastern Region of India.

PMID: 19366493 [PubMed - indexed for MEDLINE]

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4: Vet Res Commun. 2008 Sep;32 Suppl 1:S227-9. LinkOut

Corneal crystalline stromal dystrophy and lipidic metabolism in the dog.

Barsotti G, Pasquini A, Busillo L, Senese M, Cardini G, Guidi G.

Departement of Veterinary Clinical Sciences, University of Pisa, Pisa, Italy. gbarsott@vet.unipi.it

PMID: 18685968 [PubMed - indexed for MEDLINE]

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