Thursday, October 22, 2009

What's new for 'Trypanosomatids' in PubMed

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Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results
Items 1 -5 of 5

1: Biomol NMR Assign. 2009 Oct 21. [Epub ahead of print]

NMR assignment of actin depolymerizing and dynamics regulatory protein from Leishmania donovani.

Pathak PP, Pulavarti SV, Jain A, Sahasrabuddhe AA, Gupta CM, Arora A.

Molecular and Structural Biology Division, Central Drug Research Institute, CSIR, Lucknow, 226 001, India.

Leishmania donovani cofilin displays low sequence similarity to other mammalian cofilins and also possesses characteristic activity of its own. Determination of its solution structure would facilitate understanding of the molecular mechanism of actin dynamics regulation in this disease causing pathogen.

PMID: 19844807 [PubMed - as supplied by publisher]

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2: Nucleic Acids Res. 2009 Oct 20. [Epub ahead of print]

TriTrypDB: a functional genomic resource for the Trypanosomatidae.

Aslett M, Aurrecoechea C, Berriman M, Brestelli J, Brunk BP, Carrington M, Depledge DP, Fischer S, Gajria B, Gao X, Gardner MJ, Gingle A, Grant G, Harb OS, Heiges M, Hertz-Fowler C, Houston R, Innamorato F, Iodice J, Kissinger JC, Kraemer E, Li W, Logan FJ, Miller JA, Mitra S, Myler PJ, Nayak V, Pennington C, Phan I, Pinney DF, Ramasamy G, Rogers MB, Roos DS, Ross C, Sivam D, Smith DF, Srinivasamoorthy G, Stoeckert CJ Jr, Subramanian S, Thibodeau R, Tivey A, Treatman C, Velarde G, Wang H.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104 USA, Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK, Seattle Biomedical Research Institute, Seattle, WA 98109, Department of Global Health, University of Washington, Seattle, WA 98195, Center for Applied Genetic Technologies, Department of Genetics, Department of Computer Science, University of Georgia, Athens, GA 30602, Department of Medical Education and Biomedical Informatics, University of Washington, Seattle, WA 98195, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 USA and Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York YO10 5YW, UK.

TriTrypDB (http://tritrypdb.org) is an integrated database providing access to genome-scale datasets for kinetoplastid parasites, and supporting a variety of complex queries driven by research and development needs. TriTrypDB is a collaborative project, utilizing the GUS/WDK computational infrastructure developed by the Eukaryotic Pathogen Bioinformatics Resource Center (EuPathDB.org) to integrate genome annotation and analyses from GeneDB and elsewhere with a wide variety of functional genomics datasets made available by members of the global research community, often pre-publication. Currently, TriTrypDB integrates datasets from Leishmania braziliensis, L. infantum, L. major, L. tarentolae, Trypanosoma brucei and T. cruzi. Users may examine individual genes or chromosomal spans in their genomic context, including syntenic alignments with other kinetoplastid organisms. Data within TriTrypDB can be interrogated utilizing a sophisticated search strategy system that enables a user to construct complex queries combining multiple data types. All search strategies are stored, allowing future access and integrated searches. 'User Comments' may be added to any gene page, enhancing available annotation; such comments become immediately searchable via the text search, and are forwarded to curators for incorporation into the reference annotation when appropriate.

PMID: 19843604 [PubMed - as supplied by publisher]

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3: Southeast Asian J Trop Med Public Health. 2009 May;40(3):458-62.

Seasonal occurrence of phlebotominae sand flies (Phlebotominae: Diptera) and it's correlation with kala-azar in eastern Uttar Pradesh, India.

Singh NS, Singh DP.

Department of Zoology, Lucknow Christian College, Golaganj, Lucknow (U.P.), India. naveendoris@rediffmail.com

In this investigation, the species composition of sand flies, and their seasonality, nocturnal activity, sex ratio, and resting site, for implementation of future control measures, were surveyed in eastern (Gonda and Basti) Uttar Pradesh, India. Adult sand flies (2,893) were collected from internal and external sites by sticky and light traps. The sand flies were captured using light traps hung at different heights in trees and in peridomiciliary and extradomiciliary areas of a forest during both dry and rainy months. The traps were kept out between sunset and sunrise of the following day. In the extradomiciliary environment, the traps were installed at 1, 3 and 5 m above the ground. In this investigation, a total of 5 species were obtained: Phlebotomus papatasi, P. sergenti, Sergentomyia sintoni, S. punjabensis and S. dentata. The number of sand flies peaked in September and declined by December. The maximum and minimum numbers were found at 8:00 PM and 5:00 to 6:00 AM, respectively. The female to male ratio of the phlebotominae sand flies varied from a high in October to a low in June. The number of sand flies in the external regions was significantly more (p < 0.05) than the internal regions in all months except May, June, December and January. No flagellate infections were observed in any other species of sand flies. Using the results of this investigation, health workers in this area may be better able to control and prevent leishmaniasis.

PMID: 19842430 [PubMed - in process]

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4: Biomedica. 2009 Mar;29(1):119-26.LinkOut

[Life cycle of Triatoma dimidiata latreille, 1811 (Hemiptera, Reduviidae) under laboratory conditions: production of nymphs for biological tests]

[Article in Spanish]

Reyes M, Angulo VM.

Escuela de Biología, Facultad de Ciencias, Universidad Industrial de Santander, Bucaramanga, Colombia. marejez1@hotmail.com

INTRODUCTION: Despite the importance of Triatoma dimidiata as a vector of Chagas disease, little is known of its life cycle and the efficient production of these insects for biological tests. OBJECTIVE: Life cycle characteristics in the laboratory were described and optimum nutritional conditions were established for the efficient production of nymphs V stage for biological tests. MATERIALS AND METHODS: We determined the time of development of the nymphal stage under controlled laboratory conditions until reaching the adult stage. In a massive rearing of stage V nymphs, fed and weighted after varying periods of fasting, distributed in weight ranges to obtain the largest proportion of individuals. RESULTS: The time mean from egg to adult was 269 days, with a wide range of duration (174 to 598 days) and the times required for 1st, 2nd, 3rd, 4th and 5th stage development was 33, 37, 41, 61 and 69 days, respectively, with a mortality of 22%. The optimum treatment was 22 days of fasting, in which 76% of the nymphs reached stage V with a weight range from 201 to 300 mg. CONCLUSION: Triatoma dimidiata presented development time with broad range for some individuals, possibly due to the irregularity in the food availability. A homogenous weight range was attained with a regime of 22 days of fasting with an optimum production of stage V nymphs.

PMID: 19753845 [PubMed - indexed for MEDLINE]

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5: Biomedica. 2009 Mar;29(1):18-24.LinkOut

[Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy]

[Article in Spanish]

Rodríguez G, Pinto R, López F, Gómez Y.

Grupo de Microbiología Molecular, Facultad de Medicina, Universidad de La Sabana, Chía, Cundinamarca. gerzain_rodriguez@yahoo.com

INTRODUCTION: Clofazimine enterophathy is a serious complication of clofazimine when used at high doses for treatment of type 2 lepra or or erythema nodosum leprosum. Objective. A woman is presented who had a delayed diagnosis of leprosy, persistent type 2 lepra reaction and lethal clofazimine enteropathy. MATERIALS AND METHODS: A 31-year-old woman presented leprosy symptoms over a 16-year period without medical diagnosis of her disease. During this period, type 2 lepra episodes occurred, but were not accurately diagnosed. These episodes became more severe during her second pregnancy. The patient and her family were interviewed, and her clinical history reviewed. RESULTS: After twelve years of medical consults, lepromatous leprosy was diagnosed, based on perforation of her nasal septum, with a bacterial index of 5. Her husband and a 12-year-old daughter have leprosy symptoms. During multidrug therapy, she presented with repeated type 2 lepra reaction episodes for which she received daily clofazimine 400 mg doses. Two months after this treatment, severe and frequent episodes of intense abdominal pain began to occur. These persisted for more than a year and were managed with in-hospital administration of several classes of painkillers and antispasmodic medication, including morphine. She also presented with sporadic diarrhea, constipation, nausea, weight loss and mesenteric adenopathies. She died finally due to this intestinal condition. No autopsy was performed. CONCLUSIONS: The patient's clinical presentation suggested a clofazimine-induced lethal enteropathy, a complication not previously seen in Colombia. This connection was not recognized by the medical officers that treated the patient.

PMID: 19753835 [PubMed - indexed for MEDLINE]

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