What's new for 'Trypanosomatids' in PubMed

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Sent on Friday, 2010 Jan 01
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results

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1.	J Biol Chem. 2009 Dec 30. [Epub ahead of print] TbPIF1, a Trypanosoma brucei mitochondrial DNA helicase, is essential for kinetoplast minicircle replication. Liu B, Yildirir G, Wang J, Tolun G, Griffith JD, Englund PT. Duke University, United States; Kinetoplast DNA (kDNA), the trypanosome mitochondrial genome, is a network of interlocked DNA rings including several thousand minicircles and a few dozen maxicircles. Minicircles replicate after release from the network and their progeny reattach. Remarkably, trypanosomes have six mitochondrial DNA helicases related to yeast PIF1 helicase. Here we report that one of the six, TbPIF1, functions in minicircle replication. RNAi of TbPIF1 causes a growth defect and kDNA loss. Minicircle replication intermediates decrease during RNAi, and there is an accumulation of multiply-interlocked, covalently-closed minicircle dimers (fraction U). In studying the significance of fraction U, we found that this species also accumulates during RNAi of mitochondrial topoisomerase II. These data indicate that one function of TbPIF1 is an involvement, together with topoisomerase II, in segregation of minicircle progeny.
	PMID: 20042610 [PubMed - as supplied by publisher]
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2.	Med Chem. 2009 Nov;5(6):543-8. Germatranyl Substituted Organotin (IV) Carboxylates: Synthesis Spectroscopic Characterization and Biological Activities. Salma U, Imtiaz-Ud-Din, Mazhar M, Khan KM. Department of Chemistry, Allama Iqbal Open University Islamabad 44000, Pakistan. drimtiazuddin@yahoo.com. Eight new organotin (IV) derivatives of general formula [N(CH(2)CH(2)O) (3)3GeCH(R(1))CH(2)COO] (4-n) SnR(2)(1), where n = 2, R(2) = C(2)H(5) (1-5); R(1) = CH(3) (1); C(6)H(5) (2); p-CH(3)C(6)H(4) (3); p-FC(6)H(4)(4); p-CH(3)OC(6)H(4) (5) and n = 3, R(2) = CH(2)C(6)H(5) (6-8), R(1) = CH(3) (6); C(6)H(5) (7); p-CH(3)C(6)H(4) (8) have been synthesized by the reaction of di- or tri-organotin chloride with the corresponding germatranyl (substituted) propionic acid in the appropriate mole ratios using triethylamine as a base. The synthesized compounds were characterized by various spectroscopic techniques such as IR, multi-nuclear ((1)H, (13)C, (119)Sn) NMR, (119m)Sn Mössbauer, along with elemental analyses. They were also screened for in vitro anti-leishmanial activity against promastigotes of leishmania donovani and found some encouraging results.
	PMID: 20041833 [PubMed - in process]
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