What's new for 'Trypanosomatids' in PubMed

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Sent on Wednesday, 2010 Jun 09
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results

Items 1 - 3 of 3

1.	J Biomed Biotechnol. 2010;2010:389153. Epub 2010 Feb 23. Immunobiology of African trypanosomes: need of alternative interventions. Baral TN. Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Dr. Ottawa, ON, Canada K1A 0R6. toyanath.baral@nrc.ca Abstract Trypanosomiasis is one of the major parasitic diseases for which control is still far from reality. The vaccination approaches by using dominant surface proteins have not been successful, mainly due to antigenic variation of the parasite surface coat. On the other hand, the chemotherapeutic drugs in current use for the treatment of this disease are toxic and problems of resistance are increasing (see Kennedy (2004) and Legros et al. (2002)). Therefore, alternative approaches in both treatment and vaccination against trypanosomiasis are needed at this time. To be able to design and develop such alternatives, the biology of this parasite and the host response against the pathogen need to be studied. These two aspects of this disease with few examples of alternative approaches are discussed here. PMCID: PMC2826769 Free PMC Article
	PMID: 20182644 [PubMed - indexed for MEDLINE]
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2.	Trop Anim Health Prod. 2010 Apr;42(4):769-76. Serological and parasitological survey of dourine in the Arsi-Bale highlands of Ethiopia. Hagos A, Abebe G, Büscher P, Goddeeris BM, Claes F. Faculty of Veterinary Medicine, Department of Pathology and Parasitology, Addis Ababa University, P.O. Box 34, Debre Zeit, Ethiopia. hagos83@yahoo.com Abstract This study was conducted from August 2005 to January 2007 to determine prevalence and distribution of dourine in horses and to investigate the occurrence of clinical and carrier cases in donkeys and mules in the Arsi-Bale highlands. Study methodology was based on questionnaire, serological, clinical and parasitological survey. The questionnaire indicated that dourine is a major health problem of equines in the Arsi-Bale highlands. Though dourine is commonly observed throughout the year, it has a seasonal character and occurs mostly during the breeding season from June to late September. Serological screening of 646 horses showed a seroprevalence of 184 (28%), 161 (25%) and 125 (19%) for card agglutination test for trypanosomosis, LATEX and enzyme-linked immunosorbent assay, respectively. Risk factors were parity number, previous history of abortion and body condition score. No trypanosomes could be detected by Giemsa staining or by haematocrit centrifugation technique. Ten puppies inoculated with blood samples, genital washes and oedematous fluids remained parasitologically negative. Different characteristic signs of dourine were observed. During the genital stage, mares showed vaginal oedema, discharge and presence of depigmented scars over the external genitalia. In stallions, oedema of the scrotum and prepuce, prepucial and urethral discharge, and ulceration of the genital mucosae mainly of the penile were observed. In both sexes, lameness in one or both legs, partial dragging and stiffness of the hind legs and incoordination were the dominant signs observed as nervous form of the disease.
	PMID: 19924557 [PubMed - indexed for MEDLINE]
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3.	Trop Anim Health Prod. 2010 Apr;42(4):589-95. Epub 2009 Sep 27. Immune responses to haemorrhagic septicaemia (HS) vaccination in Trypanosoma eva nsi infected buffalo-calves. Singla LD, Juyal PD, Sharma NS. Department of Veterinary Parasitology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141004, India. ldsingla@gmail.com Abstract To assess the immunosuppressive effect of Trypanosoma evansi infection in buffalo-calves on immune responses to heterologous antigen, the study was planned to examine the responses of haemorrhagic septicaemia vaccination in simultaneously and previously (80 days before vaccination) T. evansi-infected buffalo-calves. Eight buffalo-calves were divided into three groups. Buffalo-calves of group A (n = 3) were previously (80 days before primary vaccination with haemorrhagic septicaemia [HS] vaccine) infected with T. evansi (1 x 10(7) tryps.calf(-1); sc) and that of group B (n = 3) were infected with T. evansi (1 x 10(7) tryps.calf(-1); sc) on the day of primary vaccination with HS vaccine. Two healthy uninfected control calves given only HS vaccine were kept in group C. All the buffalo-calves were given a booster dose of vaccine 21 days post-primary vaccination (PPV). Twenty eight days PPV, animals of group A were given trypanocidal quinapyramine prosalt at 6.66 mg kg(-1). Immunosuppressive effect of T. evansi infection was evident from day 7 PPV with HS vaccine. The effect was more pronounced in previously T. evansi-infected buffalo-calves as compared with simultaneously infected buffalo-calves. Group A buffalo-calves appeared to have recovered from the immunosuppressive effect after 28 days post-trypanocidal treatment as observed by humoral and cell-mediated immune responses. Immunosuppressive effect to HS vaccination was observed in T. evansi-infected buffalo-calves, and trypanocidal therapy enabled the calves to mount the responses similar to uninfected controls.
	PMID: 19784863 [PubMed - indexed for MEDLINE]
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