What's new for 'Trypanosomatids' in PubMed

This message contains My NCBI what's new results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM).
Do not reply directly to this message.

Sender's message:

Sent on Thursday, 2010 Jul 01
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
Click here to view complete results in PubMed. (Results may change over time.)
To unsubscribe from these e-mail updates click here.

PubMed Results

Items 1 - 9 of 9

1.	Pharm Unserer Zeit. 2010 Jun 29;39(4):261-262. [Epub ahead of print] Trypanosomen im Fokus. Holzgrabe U. Würzburg. Abstract Zu den vernachlässigten tropischen Erkrankungen (neglected tropical diseases, NTD), die die höchste Todesrate aufweisen, gehören die durch die Protozoen Trypanosoma und Leishmania verursachte Chagas-Krankheit (Trypanosoma cruzi), die Schlafkrankheit, auch humane afrikanische Trypanosoma genannt (Trypanosoma brucei rhodesiense und gambiense) und die viszerale Leishmaniose (Leishmania donavani). Sie kommen vor allem in den ärmsten, ländlichen Gegenden unseres Planeten vor, in Subsahara-Afrika, Südasien und Lateinamerika.
	PMID: 20589793 [PubMed - as supplied by publisher]

2.	Rev Argent Microbiol. 2010 Mar-Apr;42(2):118-21. [Recidivant laryngeal leishmaniosis: an unusual case in an immunocompetent patient treated with corticosteroids.] [Article in Spanish] Casero R, Laconte L, Fraenza L, Iglesias N, Quinteros Greco C, Villablanca M. Departamento de Parasitología, Hospital Nacional de Clínicas, Universidad Nacional de CórdobaCórdoba, 5008, Argentina. Abstract Leishmaniosis is a chronic parasitic disease, which in Argentina is mainly caused by protozoa belonging to the Leishmania (Viannia) braziliensis complex, leading to cutaneous and mucosal pathologies. We report a rare case of laryngeal leishmaniosis in a 29 year-old man from Jujuy province, Argentina, who had been misdiagnosed with other pathologies, carrying this infectious disease for about 20 years. During 2008, the patient was admitted with complaints of progressive hoarseness of the voice and dyspnea. He also reported having received tuberculostatics, antifungal and corticosteroids treatments since 2002. Different biopsies and direct laryngoscopic exams revealed inespecific granulomatous larynx, TBC-related laryngitis, laryngitis related to Histoplasma infection, extra-nodal Natural Killer-cell lymphoma. Finally, the patient was evaluated at the University Hospital and the final diagnosis was: granulomatous larynx, intra and extra-cytoplasmic Leishmania spp amastigotes, negative for TBC and Histoplasma cultures, and chronic laryngitis related to Leishmania infection, according to the laryngeal endoscopy, microbiological and histopathological exams, respectively. The patient received pentavalent antimonial treatment and his condition improved after 2 months of follow-up. Primary laryngeal leishmaniosis is rare and this localization does not belong to the most prevalent mucosal leishmaniosis. However, this parasitic disease warrants special concern, especially in patients who received prolonged corticosteroid treatments, in order to avoid a misdiagnosis of this disease.
	PMID: 20589333 [PubMed - in process]

3.	J Biomed Biotechnol. 2010;2010:827851. Epub 2010 May 31. The Vectorial Potential of Lutzomyia (Nyssomyia) intermedia and Lutzomyia (N.) whitmani in the Transmission of Leishmania (V.) braziliensis Can Also Be Related to Proteins Attaching. Alves CR, Côrtes LM, Brazil RP. Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz-FIOCRUZ, Avenida Brasil 4365, Manguinhos, 21045-900, Rio de Janeiro, RJ, Brazil.
	PMID: 20589075 [PubMed - in process]

4.	J Antibiot (Tokyo). 2010 Jun 30. [Epub ahead of print] In vitro and in vivo anti-Trypanosoma brucei activities of phenazinomycin and related compounds. Otoguro K, Ishiyama A, Iwatsuki M, Namatame M, Nishihara-Tukashima A, Nakashima T, Shibahara S, Kondo S, Yamada H, Omura S. Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
	PMID: 20588299 [PubMed - as supplied by publisher]

5.	Int J Exp Pathol. 2010 Jun 25. [Epub ahead of print] Histopathological analysis of initial cellular response in TLR-2 deficient mice experimentally infected by Leishmania (L.) amazonensis. Silva CG, Macedo Silva RM, Carvalho LO, Calabrese KD, Bozza PT, Côrte-Real S. Laboratory of Structural Biology, Oswaldo Cruz Institute, FIOCRUZ - Rio de Janeiro/RJ-Brazil. Abstract Summary Tegumentary leishmaniasis is an important public health problem in several countries. The capacity of the Leishmania species, at the initial moments of the infection, to invade and survive inside the host cells involves the interaction of surface molecules that are crucial in determining the evolution of the disease. Using C57BL/6 wild-type and TLR-2(-/-) mice infected with L. (L.) amazonensis, we demonstrated that TLR-2(-/-) mice presented eosinophilic granuloma in the ear dermis, different from C57BL/6 wild-type mice that presented a cellular profile characterized mainly by mononuclear cell infiltrates, besides neutrophils and eosinophils, during the two first week of infection. When the parasite load was evaluated, we found that the absence of TLR-2 lead to a significant reduction of the infection in deficient mice, when compared with C57BL/6 mice which were more susceptible to the infection. Using TLR-2 deficient mice, it was possible to show that the absence of this receptor determined the reduction of the parasite load and the recruitment of inflammatory cells during the two first weeks after L. (L.) amazonensis infection.
	PMID: 20586817 [PubMed - as supplied by publisher]

6.	Expert Rev Anti Infect Ther. 2010 Jul;8(7):739-42. Immunomodulators: use in combined therapy against leishmaniasis. Dalton JE, Kaye PM. Centre for I mmunology and Infection, Department of Biology and Hull York Medical School, University of York, York, YO10 5YW, UK. jd550@york.ac.uk.
	PMID: 20586558 [PubMed - in process]

7.	J Biosci Bioeng. 2010 May;109(5):459-65. Epub 2009 Nov 10. Production improvement of antifungal, antitrypanosomal nucleoside sinefungin by rpoB mutation and optimization of resting cell system of Streptomyces incarnatus NRRL 8089. Fukuda K, Tamura T, Ito H, Yamamoto S, Ochi K, Inagaki K. Department of Bioresources Chemistry, Graduate School of Natural Science and Technology, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. Abstract Sinefungin, a nucleoside antibiotic with potent antifungal, antiviral, and anti-trypanosome activities, has been a target for production enhancement in the past decades through medium optimization and strain improvement. For the purpose of introducing a more rational approach, we induced rpoB mutation in the producer strain, Streptomyces incarnatus NRRL 8089, by optimized UV-irradiation, and a resulting rifampicin-resistant strain rif-400 increased the sinefungin production by 7-fold. The growth and melanin production were obviously accelerated in the rifampicin-resistant high-producer mutant, while the morphological differentiation such as aerial mycelia and spiked-spore formation was retained. Molecular cloning and DNA sequencing identified a single mutation A1340G in the rpoB gene, which encodes the beta-subunit of RNA polymerase, and the resulting amino acid substitution Asp447Gly corresponded to one of mutations that reportedly allowed the transcriptional up-regulation of actinorhodin production in S. coelicolor A3(2). Sinefungin production was further enhanced by resting cell system using the rpoB mutant strain in the presence of 10 mM L-Arg. D-Arg or L-ornithine did not enhance the sinefungin production, and >50 mM urea strongly suppressed the nucleoside antibiotic production, supporting the proposed biosynthetic mechanism by which urea is liberated from the guanidino-group-bearing intermediate that is produced by enzymatic condensation of L-Arg and ATP. (c) 2009 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.
	PMID: 20347768 [PubMed - indexed for MEDLINE]
	Related citations

8.	Vet Parasitol. 2010 May 11;169(3-4):320-6. Epub 2010 Jan 7. Epidemiologic aspects of an outbreak of Trypanosoma vivax in a dairy catt le herd in Minas Gerais state, Brazil. Cuglovici DA, Bartholomeu DC, Reis-Cunha JL, Carvalho AU, Ribeiro MF. Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, C.P. 486, Belo Horizonte, CEP 30.270-901, Minas Gerais, Brazil. Abstract The aim of this study was to assess the epidemiological situation of bovine trypanosomiasis caused by Trypanosoma vivax in a dairy cattle herd from Igarapé, Minas Gerais state, Brazil. The herd was monitored from September 2007 to February 2009 by sampling blood for determination of packed cell volume (PCV), microhaematocrit centrifugation test of parasitaemia (MHCT), serology (IFA), morphological identification of T. vivax and molecular diagnosis by polymerase chain reaction (PCR). During all the experimental period, 25 animals were MHCT and PCR positive, considering that in each sample collection a mean of 70 animals was evaluated. The morphometric characteristics of trypomastigote forms confirmed the infection by T. vivax. The seroprevalence ranged from 7.4% in September 2007 to 48% in February 2009, and the highest incidence observed could be correlated with an increased population of Stomoxys calcitrans flies in that region. Anaemia was the most important change found in infected animals, which showed lower averages of PCV than parasitologically negative animals (p<0.0001). Infected individuals showed lower averages of PCV than parasitologically negative animals (p<0.0001), indicating higher anaemia in the former compared with the latter group. (c) 2010 Elsevier B.V. All rights reserved.
	PMID: 20138431 [PubMed - indexed for MEDLINE]
	Related citations

9.	Oecologia. 2010 Jan;162(1):81-9. Epub 2009 Aug 27. Consumption of a nectar alkaloid reduces pathogen load in bumble bees. Manson JS, Otterstatter MC, Thomson JD. Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada. jessamyn.manson@utoronto.ca Abstract Diet has a significant effect on pathogen infections in animals and the consumption of secondary metabolites can either enhance or mitigate infection intensity. Secondary metabolites, which are commonly associated with herbivore defense, are also frequently found in floral nectar. One hypothesized function of this so-called toxic nectar is that it has antimicrobial properties, which may benefit insect pollinators by reducing the intensity of pathogen infections. We tested whether gelsemine, a nectar alkaloid of the bee-pollinated plant Gelsemium sempervirens, could reduce pathogen loads in bumble bees infected with the gut protozoan Crithidia bombi. In our first laboratory experiment, artificially infected bees consumed a daily diet of gelsemine post-infection to simulate continuous ingestion of alkaloid-rich nectar. In the second experiment, bees were inoculated with C. bombi cells that were pre-exposed to gelsemine, simulating the direct effects of nectar alkaloids on pathogen cells that are transmitted at flowers. Gelsemine significantly reduced the fecal intensity of C. bombi 7 days after infection when it was consumed continuously by infected bees, whereas direct exposure of the pathogen to gelsemine showed a non-significant trend toward reduced infection. Lighter pathogen loads may relieve bees from the behavioral impairments associated with the infection, thereby improving their foraging efficiency. If the collection of nectar secondary metabolites by pollinators is done as a means of self-medication, pollinators may selectively maintain secondary metabolites in the nectar of plants in natural populations.
	PMID: 19711104 [PubMed - indexed for MEDLINE]
	Related citations