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Sent on Saturday, 2010 Jul 03Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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| PubMed Results |
| 1. | Turkiye Parazitol Derg. 2010;34(2):137-144.[Protozoons and Arthropods Found in Eyes.][Article in Turkish] Gökpinar S, Aydenızöz M.Kirikkale Universitesi Veteriner Fakültesi, Parazitoloji Anabilim Dali, Kirikkale, Turkey. AbstractProtozoons and arthropods can be observed commonly all around the world including our country. These parasites can cause different kind of disorders in human and animals. Some of these can cause eye disorders. The aim of this review was to present information about how the protozoons such as Toxoplasma gondii, Leishmania spp., Trypanosoma spp., Giardia spp., Acanthamoeba spp., Plasmodium spp., the arthropods insects of myiasis, Phthirus pubis, ticks, Demodex folliculorum and Linguatula serrata (under discussion as to which order it beongs) invade the eye of host leading to clinical symptoms, diagnosis and treatment. |
| PMID: 20597061 [PubMed - as supplied by publisher] | |
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| 2. | Turkiye Parazitol Derg. 2010;34(2):122-130.[Approaches and Problems in Vaccine Development against Leishmaniasis.][Article in Turkish] Allahverdiyev A, Bağirova M, Koç RC, Oztel ON, Elçıçek S, Ateş SC, Karaca TD.Yildiz Teknik Universitesi, Kimya-Metalurji Fakültesi, Biyomühendislik Bölümü, Esenler, Istanbul, Turkey. AbstractLeishmaniasis is a major public health problem of the world and Turkey. Recently there has been increasing interest in vaccine studies among strategies for control of leishmaniasis. Recently the increase of interest in vaccine studies among leishmaniasis control strategies makes the subject more up to date. So the aim of this review is to present information about recent vaccine studies, problems and new strategies for vaccine development studies. There are 3 generations of vaccine against leishmaniasis. First-generation vaccines are killed or live attenuated parasites; second-generation vaccines are recombinant or native antigens and live genetically modified parasites (knock out and suicidal cassettes), third generation vaccines are DNA vaccines. Also vector salivary proteins, dendritic cells and non-pathogenic L. tarentolae have been used as vaccine candidates. However there is still no effective vaccine against leishmaniasis. Since polymer conjugates considerably increase immunogenicity, polymer based vaccine studies have gained importance in recent years. However, there has not been such a study for an antileishmanial vaccine yet. LPG, surface antigen of Leishmania promastigotes, and polymer conjugates may be promising in antileishmanial vaccine studies so we are carrying out a TUBITAK Project on this subject which has been given the number, 1085170SBAG-4007. |
| PMID: 20597059 [PubMed - as supplied by publisher] | |
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| 3. | Turkiye Parazitol Derg. 2010;34(2):106-111.[Population Density of Phlebotomus (Diptera; Psychodidae; Phlebotomine) Species and Their Relationship with Cutaneous Leishmaniasis in Hocalli and Turunçlu Villages (Adana).][Article in Turkish] Atakan E, Akbaba M, Sütoluk Z, Alptekın D, Demırhındı H, Uludağ SK.Cukurova Universitesi Ziraat Fakültesi, Bitki Koruma Bölümü, Adana, Turkey. AbstractThe aim of this study was the detection of cutaneous leishmaniasis (CL) cases at Turunçlu and Hocalli Villages, Adana, Turkey, where local cases had been observed in recent years, and to determine possible vectors and their seasonal density distribution. This was for the purpose of encouraging public awareness and thus leading to prevention. An initial questionnaire was responded by 567 people, with a male-to-female ratio of 45% to 55%. The physician in the research group examined the whole population of both villages for CL and then made monthly visits in order to detect new cases. Adhesive paper traps and CDC light traps were placed in houses and animal stables in order to collect sandflies, whose species were later determined in the laboratory. The CL prevalence was found to be 7.2%, with 30 old cases and11 new cases. The number of cases in the Turunçlu Village was high with 17 men and 24 women affected. The case frequencies were not different between men and women (p > 0.05). The houses being whitewashed or kind of animal feeding were not found to affect the frequency of CL. In the two villages, 88 Phlebotomus were detected. P. papatasi and P. tobbi were of the genus Phlebotomus, while the genus Sergentomia was also observed. P.papatasi was most frequent in adhesive paper traps, while P.tobbi was frequent in light traps. |
| PMID: 20597056 [PubMed - as supplied by publisher] | |
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| 4. | Turkiye Parazitol Derg. 2010;34(2):76-80.[Seroprevalance of Listeriosis and Leishmaniasis in Shelter Dogs of the Erzurum Province.][Article in Turkish] Aktaş MS, Ozkanlar YE, Ozkan AT, Babür C, Balkaya I.Atatürk Universitesi Veteriner Fakültesi, Iç Hastaliklari Anabilim Dali, Erzurum, Turkey. AbstractDogs are known to play an important role in the spread of the zoonotic diseases, listeriosis and leishmaniasis. In this study, the seroprevalances of these infections were investigated in shelter dogs in Erzurum. The Osebold agglutination test for listeriosis and IFAT for leishmaniasis were performed in analysis of the specimens. Out of 72 dogs, 19 (26.3%) were found to be seropositive for Listeria monocytogenes. Leishmaniasis seropositivity was not detected in any of the specimens. A total of 13 (29.5%) of female dogs and 6 (21.4%) of male dogs were L. monocytogenes positive. Seropositivity rates were 41.6% in dogs less than 1 year old, 24% in those 1-3 years old, and 16.6% in those over 3 years old. Regarding percentages, the seropositivity rate of L. monocytogenes was found to be higher in female dogs and those younger. However, these changes were not found to be statistically significant (p > 0.05). Detection of L. monocytogenes in dogs of Erzurum province was considered to be crucial for veterinary medicine and public health and preventive measures should be taken as soon as possible. |
| PMID: 20597049 [PubMed - as supplied by publisher] | |
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| 5. | Turkiye Parazitol Derg. 2010;34(2):73-75.[Case Report: The Eff icacy of Amphotericine B in Visceral Leishmaniasis.][Article in Turkish] Güleç SG, Kizilyer Y, Karaman S, Erdem E, Urganci N.Sişli Etfal Eğitim ve Araştirma Hastanesi, Pediatri Kliniği, Istanbul, Turkey. AbstractLeishmaniasis is a zoonotic disease which may be difficult to diagnose in children. Successful results have been achieved with amphotericin B in treatment. Here, we present a 7 month old girl who lives in Istanbul. She was given a diagnosis of kala-azar and treated with liposomal amphotericin B. Our case, born in Istanbul, had had fatigue for 3 weeks and pallor and abdominal distention for 2 days. History of travel was absent. In physical examination, paleness, malaise and hepatosplenomegaly were found. In laboratory findings there was pancytopenia and her albumin level was low. A peripheric smear and other laboratory findings were normal. Her first bone marrow aspiration was normal. Because of persistent fever and increase in hepatosplenomegaly, a second bone marrow aspiration was done on the tenth day after admission and Leismania amastigotes were seen. She was given a diagnosis of kala-azar and, clinical and microbiological responses were achieved by treatment with amphotericin B. In our country, visceral leishmaniasis should be considered in all age groups who live in western regions and have no history of travel and contact, that present with pancytopenia or bicytopenia, even if massive splenomegaly is absent. |
| PMID: 20597048 [PubMed - as supplied by publisher] | |
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| 6. | Am J Trop Med Hyg. 2010 Jul;83(1):97-101.A Controlled, Randomized-Blinded Clinical Trial to Assess the Efficacy of a Nitric Oxide Releasing Patch in the Treatment of Cutaneous Leishmaniasis by Leishmania (V.) panamensis.López-Jaramillo P, Rincón MY, García RG, Silva SY, Smith E, Kampeerapappun P, García C, Smith DJ, López M, Vélez ID.VILANO Group, Fundación Cardiovascular de Colombia, Floridablanca, Colombia; Facultad de Medicina, Universidad de Santander (UDES), Bucaramanga, Colombia; University of Akron, Akron, Ohio; Free Radical Research Center, Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin; Secretaria de Salud de Santander, Bucaramanga, Colombia; Programa de Estudio y Control de Enfermedades Tropicales PECET, Universidad de Antioquia, Medellín, Colombia. AbstractA topical nanofiber nitric oxide (NO) releasing patch ( approximately 3.5 mumol NO/cm(2)/day for 20 days, NOP) was compared with intramuscular meglumine antimoniate (Glucantime, 20 mg/kg/day for 20 days) for the treatment of cutaneous leishmaniasis (CL) caused by Leishmania (V.) panamensis in Santander and Tolima, Colombia. A double-blind, randomized, placebo-controlled, clinical trial was conducted to determine whether the NOP is as effective as Glucantime for the treatment of CL. Patients were randomly assigned to Glucantime and placebo patches or NOP and placebo of Glucantime. The cure rates after a 3-month follow-up were 94.8% for the group that received Glucantime compared with 37.1% in the NOP group. Despite the lower efficacy of the NOP versus Glucantime, a significantly lower frequency of non-serious adverse events and a reduced variation in serum markers were observed in patients treated with NOP. Treatment of CL with NOP resulted in a lower effectiveness compared with Glucantime; however, the low frequency of adverse events and the facility of topic administration justify the development of new generations of NOP systems for the treatment of CL. |
| PMID: 20595484 [PubMed - as supplied by publisher] | |
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| 7. | Am J Trop Med Hyg. 2010 Jul;83(1):10-12.Visceral Leishmaniasis Treated with Antimonials/Paromomycin followed by Itraconazole/Miltefosine after Standard Therapy Failures in a Human Immunodeficiency Virus-Infected Patient.Barragán P, López-Velez R, Olmo M, Podzamczer D.Infectious Disease Service, Hospital Universitari de Bellvitge, L'Hospitalet, Barcelona, Spain; Tropical Medicine and Clinical Parasitology, Infectious Diseases Department, Ramón y Cajal Hospital, Madrid, Spain. AbstractVisceral leishmaniasis is an opportunistic infection that affects human immunodeficiency virus-infected persons in leishmaniasis-endemic areas. The standard treatment may not be effective and relapses are common. We report the case of a human immunodeficiency virus-1-infected patient who had several relapses of visceral leishmaniasis after treatment with standard therapies and responded to a combined therapy. |
| PMID: 20595469 [PubMed - as supplied by publisher] | |
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| 8. | Biochimie. 2010 Jun 4. [Epub ahead of print]Immunolocalization and characterization of two novel proteases in Leishmania donovani: Putative roles in host invasion and parasite development.Choudhury R, Das P, De T, Chakraborti T.Department of Biochemistry and Biophysics, University of Kalyani, Kalyani 741235, West Bengal, India. AbstractTwo novel intracellular proteases having identical molecular mass (58 kDa) were purified from virulent Indian strain of Leishmania donovani by a combination of aprotinin-agarose affinity chromatography, ion exchange chromatography and finally continuous elution electrophoresis. Both of these proteases migrate in SDS-PAGE as a single homogeneous bands suggesting monomeric nature of these proteases. The enzyme activity of one of the proteases was inhibited by serine protease inhibitor aprotinin and another one was inhibited by metalloprotease inhibitor 1, 10 phenanthroline. The purified enzymes were thus of serine protease (SP-Ld) and metalloprotease (MP-Ld) type. The optimal pH for protease activity is 8.0 and 7.5 for SP-Ld and MP-Ld respectively. The temperature optimum for SP-Ld is 28 degrees C and for MP-Ld is 37 degrees C showing their thermostability upto 60 degrees C. Broad substrate (both natural and synthetic) specificity and the effect of Ca(2+) upon these enzymes suggested novelty of these proteases. Kinetic data indicate that SP-Ld is of trypsin like as BAPNA appears to be the best substrate and MP-Ld seems to be collagenase type as it degrades azocoll with maximum efficiency. Both immunofluorescence and immune-gold electron microscopy studies revealed that the SP-Ld is localized in the flagellar pocket as well as at the surface of the parasite, whereas MP-Ld is located extensively near the flagellar pocket region. This work also suggests that the uses of anti SP-Ld and anti MP-Ld antibodies are quite significant in interfering with the process of parasite invasion and multiplication respectively. Thus the major role of SP-Ld could be predicted in invasion process as it down regulates the phagocytic activity of macrophages, and MP-Ld appears to play important roles in parasitic development. Copyright © 2010 Elsevier Masson SAS. All rights reserved. |
| PMID: 20595064 [PubMed - as supplied by publisher] | |
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| 10. | Vet J. 2010 Jun 29. [Epub ahead of print]Long term follow-up of dogs diagnosed with leishmaniosis (clinical stage II) and treated with meglumine antimoniate and allopurinol.Torres M, Bardagí M, Roura X, Zanna G, Ravera I, Ferrer L.Department of Animal Medicine and Surgery and Veterinary Teaching Hospital, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. AbstractTwenty-three dogs with a diagnosis of leishmaniosis (clinical stage II) were treated with meglumine antimoniate and allopurinol and were followed up for 2-9years. The treatment showed efficacy and the clinical condition of the dogs improved markedly in the first 3months of treatment. Anti-Leishmania antibody titres declined slowly although most dogs remained seropositive 1year after beginning treatment. Inter-individual variability in the evolution of the titres was very high. The dogs presented with three types of complications during the follow-up period. (1) Three dogs experienced relapses characterized by clinical signs, high anti-Leishmania titres and high parasitaemia. (2) Eight dogs presented immune-mediated lesions, such as uveitis, arthritis and cutaneous vasculitis; in all of these cases, the dogs had high titres of anti-Leishmania antibodies at diagnosis and during follow-up. (3) Three dogs presented xanthine urolithiasis most likely due to the allopurinol treatment. In one case the xanthine uroliths led to hydronephrosis and nephrectomy. The study demonstrated a long survival for dogs with leishmaniosis treated with the combination of meglumine antimoniate and allopurinol. Clinicians should pay special attention to the appearance of immune-mediated lesions, especially in dogs with sustained high antibody titres, and to urolithiasis. Copyright © 2010 Elsevier Ltd. All rights reserved. |
| PMID: 20594876 [PubMed - as supplied by publisher] | |
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