What's new for 'Trypanosomatids' in PubMed

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Sent on Tuesday, 2010 Jul 27
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results

Items 1 - 5 of 5

1.	Indian J Dermatol Venereol Leprol. 2010 Jul-Aug;76(4):417-8. Liposomal zinc phthalocyanine as a potential agent for photodynamic therapy of leishmaniasis. Sazgarnia A, Bahreyni-Toosi MH, Layegh P, Rajabi O, Ghodsinia RM. Department of Medical Physics, Research Center of Medical Physics, Qaem Hospital, Mashhad, Iran.
	PMID: 20657130 [PubMed - in process]

2.	Med Mal Infect. 2010 Jul 23. [Epub ahead of print] [Contribution of 18-FDG positron emission tomography for the diagnosis of visceral leishmaniasis.] [Article in French] Casadevall M, Mambré L, Cornet M, Caillat-Vigneron N, Le Jeunne C, Aslangul E. Service de médecine interne, Hôtel-Dieu, 75004 Paris, France.
	PMID: 20656428 [PubMed - as supplied by publisher]

3.	Clin Biochem. 2010 Jul 22. [Epub ahead of print] Enzyme-linked immunosorbent assay with purified Trypanosoma cruzi excreted superoxide dismutase. Mateo H, Sánchez-Moreno M, Marín C. Abstract OBJECTIVES: Purification and biochemical characterization of a highly immunogenic extracellular superoxide dismutase of T. cruzi Maracay strain. DESIGN AND METHODS: Fractionation with ammonium sulphate (35-85%) and two continuous chromatography processes (ion exchange and filtration). RESULTS: The molecular mass of the excreted SOD purified was 25 kDa and the isoelectric point 3.9. This enzyme was validated by ELISA with the polyclonal sera obtained from Balb-C mice and with sera from 222 chagasic patients from Brazil, Chile, Colombia, Mexico and Peru plus 20 sera corresponding to leishmaniasis from Peru. All the sera from Brazil stored since 1980 were positive, 93% were positive in chronic patients with 10 years of Chagas treatment from Chile, and 87% of the patients with pace-makers in a chronic phase from Colombia. CONCLUSIONS: In comparison with the IFA test, the ELISA-SODe-CRU yield was 85.59% sensitivity and specificity100%. This method may be helpful for the diagnosis of Chagas disease. Copyright © 2010. Published by Elsevier Inc.
	PMID: 20655895 [PubMed - as supplied by publisher]

4.	Arch Pediatr. 2010 Jun;17(6):838-9. [Leishmaniasis treatment.] [Article in French] Minodier P, Jurquet AL, Noël G, Uters M, Laporte R, Garnier JM. Urgences Pédiatriques, CHU Nord, Marseille, France.
	PMID: 20654919 [PubMed - in process]

5.	Int J Parasitol. 2010 Jul 20. [Epub ahead of print] Transcriptomics throughout the life cycle of Leishmania infantum: High down-regulation rate in the amastigote stage. Alcolea PJ, Alonso A, Gómez MJ, Moreno I, Domínguez M, Parro V, Larraga V. Departamento de Microbiología Molecular y Biología de las Infecciones, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), calle Ramiro de Maeztu, 9, 28040, Madrid, Spain. Abstract Leishmania infantum is the causative agent of zoonotic visceral leishmaniasis in the Mediterranean Basin. The promastigote and amastigote stages alternate in the life cycle of the parasite, developing inside the sand-fly gut and inside mammalian phagocytic cells, respectively. High-throughput genomic and proteomic analyses have not focused their attention on promastigote development, although partial approaches have been made in Leishmania major and Leishmania braziliensis. For this reason we have studied the expression modulation of an etiological agent of visceral leishmaniasis throughout the life cycle, which has been performed by means of complete genomic microarrays. In the context of constitutive genome expression in Leishmania spp. described elsewhere and confirmed here (5.7%), we found a down-regulation rate of 68% in the amastigote stage, which has been contrasted by binomial tests and includes the down-regulation of genes involved in translation and ribosome biogenesis. These findings are consistent with the hypothesis of pre-adaptation of the parasite to intracellular survival at this stage. Copyright © 2010. Published by Elsevier Ltd.
	PMID: 20654620 [PubMed - as supplied by publisher]