What's new for 'Trypanosomatids' in PubMed

This message contains My NCBI what's new results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM).
Do not reply directly to this message.

Sender's message:

Sent on Saturday, 2010 Jul 31
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
Click here to view complete results in PubMed. (Results may change over time.)
To unsubscribe from these e-mail updates click here.

PubMed Results

Items 1 - 6 of 6

1.	Hand Surg. 2010;15(2):131-3. Extensor tendon rupture due to cutaneous leichmaniasis: a case report. Seyhan N, Keskin M, Tosun Z, Savaci N. Department of Plastic and Reconstructive Surgery, Meram Medical School, Selcuk University, Turkey. nevraseyhan@hotmail.com. Abstract Acute cutaneous leishmaniasis is a parasitic infectious disease prevalent in tropical areas. Most doctors in non-endemic countries are not familiar with this disease. Spontaneous tendon ruptures occurring by different mechanisms have been described in the literature but a tendon rupture caused by a skin ulcer secondary to a parasitic infection has not been reported before. In this article clinical and diagnostic features of cutaneous leishmaniasis are reviewed and a case with spontaneous extensor tendon rupture due to cutaneous leishmaniasis is presented.
	PMID: 20672404 [PubMed - in process]

2.	Microsc Microanal. 2010 Jul 30:1-7. [Epub ahead of print] Influence of Blue Light on the Leaf Morphoanatomy of In Vitro Kalanchoe pinnata (Lamarck) Persoon (Crassulaceae). Leal-Costa MV, Nascimento LB, Moreira ND, Reinert F, Costa SS, Lage CL, Tavares ES. Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Instituto de Biologia, Departamento de Botânica, sala A1-104, Avenida Carlos Chagas Filho, Cidade Universitária, 21.941-902, Rio de Janeiro, Brazil. Abstract Kalanchoe pinnata (Lamarck) Persoon (Crassulaceae) (air plant, miracle leaf) is popularly used to treat gastrointestinal disorders and wounds. Recently, the species was tested to treat cutaneous leishmaniasis with successful results. This medicinal activity was associated with the phenolic fraction of the plant. Blue light induces biosynthesis of phenolic compounds and many changes in anatomical characteristics. We studied the effects of supplementary blue light on the leaf morphology of in vitro K. pinnata. Plants cultured under white light (W plants) only and white light plus blue light (WB plants) show petioles with plain-convex section, amphistomatic leaf blades with simple epidermis, homogeneous mesophyll with densely packed cells, and a single collateral vascular bundle in the midrib. W plants have longer branches, a larger number of nodes per branch, and smaller leaves, whereas WB plant leaves have a thicker upper epidermis and mesophyll. Leaf fresh weight and leaf dry weight were similar in both treatments. Phenolic idioblasts were observed in the plants supplemented with blue light, suggesting that blue light plays an important role in the biosynthesis of phenolic compounds in K. pinnata.
	PMID: 20670464 [PubMed - as supplied by publisher]

3.	J Am Chem Soc. 2010 Jul 29. [Epub ahead of print] Synthesis of Multivalent Tuberculosis and Leishmania-Associated Capping Carbohydrates Reveals Structure-Dependent Responses Allowing Immune Evasion. Song EH, Osanya AO, Petersen CA, Pohl NL. Department of Chemistry and The Plant Science Institute, Gilman Hall, Iowa State University, Ames, Iowa 50011-3111 and Department of Veterinary Pathology, Veterinary Medicine, Iowa State University, Ames, Iowa 50011-1250. Abstract Mycobacterium tuberculosis and the protozoan parasites of the genus Leishmania are intracellular pathogens that can survive in macrophages-the very white blood cells of the immune system responsible for engulfing and ultimately clearing foreign invaders. The ability of these pathogens to hide within immune cells has made the design of effective therapies, including vaccines, to control tuberculosis and leishmaniasis particularly challenging. Herein we present the synthesis and development of carbohydrate-based probes to demonstrate that changes in pathogen-associated surface oligosaccharides are sufficient to alter cellular immune responses and thereby let a pathogen hide from immune surveillance.
	PMID: 20669964 [PubMed - as supplied by publisher]

4.	Mem Inst Oswaldo Cruz. 2010 Mar;105(2):233-8. In vitro and in vivo experimental models for drug screening and development for Chagas disease. Romanha AJ, Castro SL, Soeiro Mde N, Lannes-Vieira J, Ribeiro I, Talvani A, Bourdin B, Blum B, Olivieri B, Zani C, Spadafora C, Chiari E, Chatelain E, Chaves G, Calzada JE, Bustamante JM, Freitas-Junior LH, Romero LI, Bahia MT, Lotrowska M, Soares M, Andrade SG, Armstrong T, Degrave W, Andrade Zde A. Programa Integrado de Doença de Chagas, Fiocruz, Rio de Janeiro, RJ, Brasil. romanha@cpqrr.fiocruz.br Abstract Chagas disease, a neglected illness, affects nearly 12-14 million people in endemic areas of Latin America. Although the occurrence of acute cases sharply has declined due to Southern Cone Initiative efforts to control vector transmission, there still remain serious challenges, including the maintenance of sustainable public policies for Chagas disease control and the urgent need for better drugs to treat chagasic patients. Since the introduction of benznidazole and nifurtimox approximately 40 years ago, many natural and synthetic compounds have been assayed against Trypanosoma cruzi, yet only a few compounds have advanced to clinical trials. This reflects, at least in part, the lack of consensus regarding appropriate in vitro and in vivo screening protocols as well as the lack of biomarkers for treating parasitaemia. The development of more effective drugs requires (i) the identification and validation of parasite targets, (ii) compounds to be screened against the targets or the whole parasite and (iii) a panel of minimum standardised procedures to advance leading compounds to clinical trials. This third aim was the topic of the workshop entitled Experimental Models in Drug Screening and Development for Chagas Disease, held in Rio de Janeiro, Brazil, on the 25th and 26th of November 2008 by the Fiocruz Program for Research and Technological Development on Chagas Disease and Drugs for Neglected Diseases Initiative. During the meeting, the minimum steps, requirements and decision gates for the determination of the efficacy of novel drugs for T. cruzi control were evaluated by interdisciplinary experts and an in vitro and in vivo flowchart was designed to serve as a general and standardised protocol for screening potential drugs for the treatment of Chagas disease. Free Article
	PMID: 20428688 [PubMed - indexed for MEDLINE]
	Related citations

5.	Emerg Infect Dis. 2010 May;16(5):887-9. Triatoma infestans bugs in Southern Patagonia, Argentina. Piccinali RV, Canale DM, Sandoval AE, Cardinal MV, Jensen O, Kitron U, Gurtler RE. Free Article
	PMID: 20409398 [PubMed - indexed for MEDLINE]
	Related citations

6.	Emerg Infect Dis. 2010 May;16(5):871-2. Physician awareness of Chagas disease, USA. Stimpert KK, Montgomery SP. Free Article
	PMID: 20409389 [PubMed - indexed for MEDLINE]
	Related citations