What's new for 'Trypanosomatids' in PubMed

This message contains My NCBI what's new results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM).
Do not reply directly to this message.

Sender's message:

Sent on Thursday, 2010 Oct 14
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
Click here to view complete results in PubMed. (Results may change over time.)
To unsubscribe from these e-mail updates click here.

PubMed Results

Items 1 - 5 of 5

1.	Minerva Pediatr. 2010 Aug;62(4):389-95. Visceral leishmaniasis in children: a review. Palumbo E. Department of Pediatric, Hospital of Sondrio, Sondrio, Italy - emipalu2003@yahoo.it. Abstract Leishmaniasis is distributed worldwide and 13 million people are estimated to be infected, with about 1.8 million new cases each year. Approximately 50% of these patients are children. It should be suspected in children who present with specific manifestations and the diagnosis should be established, mainly by the demonstration of leishmania in tissue specimens. Molecular techniques could soon change this situation considering the promise they have shown in the diagnosis of other infectious diseases. Several advances in the treatment of visceral leishmaniasis have been accomplished during the past few years. All antileishmanial drugs are toxic and most have to be used parenterally for prolonged period. The therapy has been further complicated by large number of infected children and declining effectiveness of pentavalent antimonial compounds. Although the lipid formulations of amphotericin B are an important advance in therapy, their high cost precludes their use. Miltefosine, a phosphocholine analogue originally developed as antimalignant drug, has been found to be highly active against leishmania in vitro and in animal model. The aim of this review is to evidence the recent advances in diagnosis and treatment of visceral leishmaniasis.
	PMID: 20940672 [PubMed - in process]

2.	Curr Med Chem. 2010 Oct 13. [Epub ahead of print] The Kinetoplastid Chemotherapy Revisited: Current Drugs, Recent Advances and Future Perspectives. Castillo E, Dea-Ayuela MA, Bolás-Fernández F, Rangel M, González-Rosende ME. Department of Chemistry, Biochemistry and Molecular Biology, University CEU-Cardenal Herrera, Edificio Seminario s/n, 46113-Moncada, Valencia, Spain. eugenia@uch.ceu.es. Abstract Leishmaniasis, African sleeping sickness and Chagas disease, caused by the kinetoplastid parasites Leishmania spp, Trypanosoma brucei and Trypanosoma cruzi, respectively, are among the most important parasitic diseases, affecting millions of people and considered to be within the most relevant group of neglected tropical diseases. The main alternative to control such parasitosis is chemotherapy. Nevertheless, the current chemotherapeutic treatments are far from being satisfactory. This review outlines the current understanding of different drugs against leishmaniasis, African sleeping sickness and Chagas disease, their mechanism of action and resistance. Recent approaches in the area of anti-leishmanial and trypanocidal therapies are also enumerated, new modulators from the mode of action, development of new formulations of old drugs, therapeutic switching and "in silico" drug design.
	PMID: 20939823 [PubMed - as supplied by publisher]

3.	J Med Entomol. 2010 Sep;47(5):902-6. Development of an enzyme-linked immunosorbent assay to identify host-feeding preferences of Phlebotomus species (Diptera: Psychodidae) in endemic foci of visceral leishmaniasis in Nepal. Burniston I, Roy L, Picado A, Das M, Rijal S, Rogers M, Coosemans M, Boelaert M, Davies C, Cameron M. London School of Hygiene and Tropical Medicine, London, United Kingdom. Abstract Anthroponotic visceral leishmaniasis, transmitted by Phlebotomus argentipes Annandale & Brunetti (Diptera: Psychodidae) sand flies, is regarded as a major problem of public health importance in the Indian subcontinent. Understanding the feeding behavior of the vector can be used to investigate changes in human-vector contact during intervention programs. An enzyme-linked immunosorbent assay (ELISA) was modified to make it suitable to identify the origin of P. argentipes and Phlebotomus papatasi Scopoli (Diptera: Psychodidae) blood meals. The sensitivity and specificity of the precipitin ring test and ELISA were compared, as well as the stability of the tests across different stages of blood meal digestion. The ELISA was more sensitive and specific than the precipitin test for identifying the sources of blood meals. When using the ELISA method with a plate reader, it was possible to obtain 100% sensitivity and specificity. When comparing the techniques across digestion stages, it was found that there was a drop in sensitivity, 48 and 72 h postblood meal for precipitin and visually read ELISA, respectively. However, the sensitivity of the ELISA using a plate reader was not altered by the digestion time. The feeding habits of P. argentipes and P. papatasi from the Terai region of Nepal, determined by the ELISA developed, showed P. papatasi to be highly anthropophilic, and P. argentipes appeared to feed both on humans and animals, in particular bovines.
	PMID: 20939388 [PubMed - in process]

4.	J Med Entomol. 2010 Sep;47(5):743-7. Species-diagnostic polymerase chain reaction assays for Phlebotomus argentipes and Phlebotomus papatasi, vectors of Leishmania. Manonmani AM, Mathivanan A, Srinivasan R, Jambulingam P. Vector Control Research Centre (Indian Council of Medical Research), Medical Complex, Indira Nagar, Puducherry 605 006, India. ammanonmani@yahoo.com Abstract Species-specific differences encountered in the nucleotide sequences of a highly variable region of the 18S rRNA gene were used to design a multiplex polymerase chain reaction (PCR) assay for the identification of Phlebotomus papatasi Scopoli and Phlebotomus argentipes An-nandale & Brunetti, vectors of Leishmania. This multiplex PCR assay uses a common forward primer and two reverse primers, which are specific for the two species. Amplification of a PCR product of size 788 bp indicates the presence of P. papatasi, whereas a product of size 677 bp indicates the presence of P. argentipes. The assay was found to be highly specific and sensitive.
	PMID: 20939366 [PubMed - in process]

5.	J Antibiot (Tokyo). 2010 Sep;63(9):559-61. Epub 2010 Jun 30. Pyrenocine I, a new pyrenocine analog produced by Paecilomyces sp. FKI-3573. Hashida J, Niitsuma M, Iwatsuki M, Mori M, Ishiyama A, Namatame M, Nishihara-Tsukashima A, Nonaka K, Ui H, Masuma R, Otoguro K, Yamada H, Shiomi K, Omura S. Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
	PMID: 20588297 [PubMed - indexed for MEDLINE]
	Related citations