What's new for 'Trypanosomatids' in PubMed

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Sent on Thursday, 2010 Nov 04
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results

Items 1 - 4 of 4

1.	Indian J Pathol Microbiol. 2010 Oct-Dec;53(4):903-4. Cutaneous leishmaniasis in a soldier. Moiz B, Beg MA, Ali N. Department of Pathology and Microbiology, The Aga Khan University, Karachi, Pakistan.
	PMID: 21045484 [PubMed - in process]

2.	Bioorg Med Chem Lett. 2010 Oct 31. [Epub ahead of print] AdoHcy hydrolase of Trichomonas vaginalis: Studies of the effects of 5'-modified adenosine analogues and related 6-N-cyclopropyl derivatives. Dornbush PJ, Vazquez-Anaya G, Shokar A, Benson S, Rapp M, Wnuk SF, Wrischnik LA, Land KM. Department of Biological Sciences, University of the Pacific, Stockton, CA 95211, United States. Abstract Trypanosoma brucei and Trichomonas vaginalis are both parasitic protozoans that are known to share many similar biochemical pathways. Aristeromycin, as well as 5'-iodovinyl and 5'-oxime analogues of adenosine, are potent inhibitors of AdoHcy hydrolase in T. brucei, an enzyme that catalyses the hydrolysis of AdoHcy to adenosine and l-homocysteine. To help determine the role of this enzyme in T. vaginalis, we have tested a library of 5'-modified adenosine derivatives, including 5'-deoxy-5'-(iodomethylene)-adenosine and related 6-N-cyclopropyl analogues. Our results indicate that these inhibitors are effective at inhibiting the growth of T. vaginalis, by as much as 95%. Copyright © 2010 Elsevier Ltd. All rights reserved.
	PMID: 21044841 [PubMed - as supplied by publisher]

3.	Anal Chem. 2010 Nov 2. [Epub ahead of print] Biosensors for Efficient Diagnosis of Leishmaniasis: Innovations in Bioanalytics for a Neglected Disease. Perinoto AC, Maki RM, Colhone MC, Santos FR, Migliaccio V, Daghastanli KR, Stabeli RG, Ciancaglini P, Paulovich FV, de Oliveira MC, Zucolotto V. Instituto de Física de São Carlos, USP, CP 369, 13560-970 São Carlos, SP, Brazil, Instituto de Ciências Matemáticas e de Computação, USP, CP 668, 13560-970 São Carlos, SP, Brazil, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, USP, Ribeirão Preto, SP, Brazil, Departamento de Biofísica da Escola Paulista de Medicina, UNIFESP, São Paulo, SP, Brazil, and Universidade Federal de Rondônia (UNIR) and Fundação Oswaldo Cruz - Fiocruz Noroeste, Rondônia, Brazil. Abstract The need for reliable, fast diagnostics is closely linked to the need for safe, effective treatment of the so-called "neglected" diseases. The list of diseases with no field-adapted diagnostic tools includes leishmaniasis, shigella, typhoid, and bacterial meningitis. Leishmaniasis, in particular, is a parasitic disease caused by Leishmania spp. transmitted by infected phlebotomine sandfly, which remains a public health concern in developing countries with ca. 12 million people infected and 350 million at risk of infection. Despite several attempts, methods for diagnosis are still noneffective, especially with regard to specificity due to false positives with Chagas' disease caused by Trypanosoma cruzi . Accepted golden standards for detecting leishmaniasis involve isolation of parasites either microscopically, or by culture, and in both methods specimens are obtained by invasive means. Here, we show that efficient distinction between cutaneous leishmaniasis and Chagas' disease can be obtained with a low-cost biosensor system made with nanostructured films containing specific Leishmania amazonensis and T. cruzi antigens and employing impedance spectroscopy as the detection method. This unprecedented selectivity was afforded by antigen-antibody molecular recognition processes inherent in the detection with the immobilized antigens, and by statistically correlating the electrical impedance data, which allowed distinction between real samples that tested positive for Chagas' disease and leishmaniasis. Distinction could be made of blood serum samples containing 10(-5) mg/mL of the antibody solution in a few minutes. The methods used here are generic and can be extended to any type of biosensor, which is important for an effective diagnosis of many other diseases.
	PMID: 21043437 [PubMed - as supplied by publisher]

4.	Trends Parasitol. 2010 Aug;26(8):388-94. Epub 2010 Jun 9. Landmarks in the evolution of technologies for identifying trypanosomes in tsetse flies. Enyaru JC, Ouma JO, Malele II, Matovu E, Masiga DK. Department of Biochemistry, Makerere University, P.O. Box 7062, Kampala, Uganda. Abstract Understanding what the trypanosome pathogens are, their vectors and mode of transmission underpin efforts to control the disease they cause in both humans and livestock. The risk of transmission is estimated by determining what proportion of the vector population is carrying the infectious pathogens. This risk also depends on the infectivity of the trypanosomes to humans and livestock. Most livestock pathogens are not infective to humans, whereas the two sub-species that infect humans also infect livestock. As with other infectious diseases, we can therefore trace the foundation of many continuing disease control programs for trypanosomiasis to the discovery of the pathogens and their vectors more than a century ago. Over this period, methods for detecting and identifying trypanosomes have evolved through various landmark discoveries. This review describes the evolution of methods for identifying African trypanosomes in their tsetse fly vectors. Copyright 2010 Elsevier Ltd. All rights reserved.
	PMID: 20542733 [PubMed - indexed for MEDLINE]
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