What's new for 'Trypanosomatids' in PubMed

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Sent on Saturday, 2010 Nov 27
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results

Items 1 - 2 of 2

1.	ChemMedChem. 2010 Nov 25. [Epub ahead of print] Potent and Selective Inhibition of Cysteine Proteases from Plasmodium falciparum and Trypanosoma brucei. Ehmke V, Heindl C, Rottmann M, Freymond C, Schweizer WB, Brun R, Stich A, Schirmeister T, Diederich F. Laboratory of Organic Chemistry, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich (Switzerland), Fax: (+41) 44-632-1109.
	PMID: 21110381 [PubMed - as supplied by publisher]
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2.	Arch Pharm (Weinheim). 2010 Nov 25. [Epub ahead of print] Antimicrobial and Antineoplastic Activities of Agelasine Analogs Modified in the Purine 2-Position. Roggen H, Charnock C, Burman R, Felth J, Larsson R, Bohlin L, Gundersen LL. Department of Chemistry, University of Oslo, Blindern, Oslo, Norway. Abstract Agelasines are 7,9-dialkylpurinium salts found in marine sponges (Agelas sp.), which display a variety of antimicrobial and cytotoxic effects. We have synthesized simplified agelasine analogs modified in the purine 2-position and examined their antimicrobial and anticancer activities. The compounds were screened against Staphylococcus aureus, Escherichia coli, Mycobacterium tuberculosis, Candida krusei, and Candida albicans, protozoa causing tropical diseases (Plasmodium falciparum, Leishmania infantum, Trypanosoma cruzi, and Trypanosoma brucei), a panel of human cancer cell lines (U-937 GTB, RPMI 8226/s, CEM/s, and ACHN) as well as VERO and/or MRC-5 cells. The results indicate that the introduction of a methyl group in the purine 2-position is beneficial for antimycobacterial and antiprotozoal activity, and that amino groups may enhance activity against several cancer cell lines.
	PMID: 21110308 [PubMed - as supplied by publisher]
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