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Sent on Thursday, 2011 Jan 06Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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| PubMed Results |
| 1. | Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jan 1;67(Pt 1):33-7. Epub 2010 Dec 21.Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site.Barrack KL, Tulloch LB, Burke LA, Fyfe PK, Hunter WN.Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland. AbstractPteridine reductase (PTR1) is a potential target for drug development against parasitic Trypanosoma and Leishmania species, protozoa that are responsible for a range of serious diseases found in tropical and subtropical parts of the world. As part of a structure-based approach to inhibitor development, specifically targeting Leishmania species, well ordered crystals of L. donovani PTR1 were sought to support the characterization of complexes formed with inhibitors. An efficient system for recombinant protein production was prepared and the enzyme was purified and crystallized in an orthorhombic form with ammonium sulfate as the precipitant. Diffraction data were measured to 2.5 Å resolution and the structure was solved by molecular replacement. However, a sulfate occupies a phosphate-binding site used by NADPH and occludes cofactor binding. The nicotinamide moiety is a critical component of the active site and without it this part of the structure is disordered. The crystal form obtained under these conditions is therefore unsuitable for the characterization of inhibitor complexes. |
| PMID: 21206018 [PubMed - in process] | |
| 2. | Parasite Immunol. 2010 Nov 9. doi: 10.1111/j.1365-3024.2010.01273.x. [Epub ahead of print]Efficient control of Leishmania and Strongyloides despite partial suppression of nematode induced Th2 response in co-infected mice.Kolbaum J, Ritter U, Zimara N, Brewig N, Eschbach ML, Breloer M.Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany Department of Immunology, University of Regensburg, Regensburg, Germany. AbstractEndemic regions for the pathogenic nematode Strongyloides and parasitic protist Leishmania overlap and therefore co-infections with both parasites frequently occur. As the Th2 and Th1 immune responses necessary to efficiently control Strongyloides and Leishmania infections are known to counter regulate each other, we analyzed the outcome of co-infection in the murine system. Here we show that L. major specific Th1 responses partially suppressed the nematode induced Th2 response in co-infected mice. Despite this modulation, successful expulsion of gut dwelling Strongyloides was not suppressed in mice with pre-existing or subsequent Leishmania infection. A pre-existing Strongyloides infection, in contrast, did not interfere with efficient type-1 responses but even increased pro-inflammatory cytokine production. Also control of L. major infections was not affected by pre-existing nematode infection. Taken together, we provide evidence that simultaneous presence of helminth and protist parasites did not interfere with efficient host defense in our co-infection model. Copyright © 2010 Blackwell Publishing Ltd. |
| PMID: 21204851 [PubMed - as supplied by publisher] | |
| 3. | Expert Opin Ther Pat. 2011 Jan 5. [Epub ahead of print]Microtubules as antifungal and antiparasitic drug targets.Chatterji BP, Jindal B, Srivastava S, Panda D.Indian Institute of Technology Bombay, Department of Biosciences and Bioengineering, Powai, Mumbai-400076, India. AbstractIntroduction: Diseases caused by fungi and parasites are major illnesses in humans as well as in animals. Microtubule-targeted drugs are highly effective for the treatment of fungal and parasitic infections; however, several human parasitic infections such as malaria, trypanosomiasis and leishmaniasis do not have effective remedial drugs. In addition, the emergence of drug-resistant fungi and parasites makes the discovery of new drugs imperative. Areas covered: This article describes similarities and dissimilarities between parasitic, fungal and mammalian tubulins and focuses on microtubule-targeting agents and therapeutic approaches for the treatment of fungal and parasitic diseases. New microtubule-targeted antileishmanial, antimalarial and antifungal drugs, with structures, biological activities and related patents, are described. The potential of dsRNA against tubulin to inhibit proliferation of protozoan and helminthic parasites is also discussed. Patent documents up to 2010 have been searched on USPTO, Patentscope, and Espacenet resources. Expert opinion: The article suggests that vaccination with tubulin may offer novel opportunities for the antiparasitic treatment. Native or recombinant tubulin used as antigen has been shown to elicit immune response and cure infection partially or fully in animals upon challenge by protozoan parasites and helminths, thus indicating the suitability of tubulin as a vaccine against parasitic diseases. |
| PMID: 21204724 [PubMed - as supplied by publisher] | |
| 4. | Rev Soc Bras Med Trop. 2010 Jun;43(3):249-53.American tripanosomiasis: a study on the prevalence of Trypanosoma cruzi and Trypanosoma cruzi-like organisms in wild rodents in San Luis province, Argentina.Brigada AM, Doña R, Caviedes-Vidal E, Moretti E, Basso B.Departamento de Bioquímica y Ciencias Biológicas, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina. abrigad@unsl.edu.ar AbstractINTRODUCTION: Chagas disease is caused by Trypanosoma cruzi. Wild and perianthropic mammals maintain the infection/transmission cycle, both in their natural habitat and in the peridomestic area. The aim of this paper was to present the results from a study on wild rodents in the central and northern regions of San Luis province, Argentina, in order to evaluate the prevalence of this infection. METHODS: Sherman traps were set up in capture areas located between latitudes 32 masculine and 33 masculine S, and longitudes 65 masculine and 66 masculine W. The captured rodents were taxonomically identified and hemoflagellates were isolated. Morphological, biometric and molecular studies and in vitro cultures were performed. Infection of laboratory animals and histological examination of the cardiac muscle and inoculation area were also carried out. Parasites were detected in circulating blood in Calomys musculinus, Graomys griseoflavus, Phyllotis darwini and Akodon molinae. The parasites were identified using biological criteria. Molecular PCR studies were performed on some isolates, which confirmed the characterization of these hemoflagellates as Trypanosoma cruzi. RESULTS AND CONCLUSIONS: Forty-four percent of the 25 isolates were identified as Trypanosoma cruzi, and the remaining 56% as Trypanosoma cruzi-like. These findings provide evidence that wild rats infected with Trypanosoma cruzi and Trypanosoma cruzi-like organisms are important in areas of low endemicity. |
| PMID: 20563490 [PubMed - indexed for MEDLINE] | |
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| 5. | Antiseptic. 1947 Jul;44(7):445-9.Transmission of Indian kala-azar to man and study of the vector.SARKAR KD. |
| PMID: 20259482 [PubMed - indexed for MEDLINE] | |
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| 6. | J Infect Dis. 1947 Jul-Aug;81(1):14-8.The mechanism of drug resistance in trypanosomes; a method for differentiating strains of resistant trypanosomes.SCHUELER FW, CHEN G, GEILING EM. |
| PMID: 20255487 [PubMed - indexed for MEDLINE] | |
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| 7. | Blood. 1947 Jul;2(4):381-5.Hematologic observations in a case of kala-azar.BACHMILEWITZ M, BRAUN K, DE VRIES A. |
| PMID: 20247870 [PubMed - indexed for MEDLINE] | |
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| 8. | Riforma Med. 1947 Jun 15;61(21-22):256-9.[Not Available].[Article in Undetermined Language] D'ALESSANDRO G, BURGIO GR, MARIANI M. |
| PMID: 20260080 [PubMed - indexed for MEDLINE] | |
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| 9. | Rev Med Costa Rica. 1947 May;7(157):105-13.[Not Available].[Article in Undetermined Language] OVARES JC, PIEDRA B R, QUIROS M F. |
| PMID: 20260065 [PubMed - indexed for MEDLINE] | |
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| 10. | Ann Trop Med Parasitol. 1947 May;41(1):118-28.Sodium stibogluconate in the treatment of kalaazar; report on the treatment of eight cases and the appearance of probable drug reactions.MAEGRAITH B, BRUNDRETT JC, et al. |
| PMID: 20249296 [PubMed - indexed for MEDLINE] | |
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