What's new for 'Trypanosomatids' in PubMed

This message contains My NCBI what's new results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM).
Do not reply directly to this message.

Sender's message:

Sent on Sunday, 2011 Jun 12
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
Click here to view complete results in PubMed. (Results may change over time.)
To unsubscribe from these e-mail updates click here.

PubMed Results

Items 1 - 5 of 5

1.	Adv Exp Med Biol. 2011;712:84-99. Cysteine peptidases of kinetoplastid parasites. Caffrey CR, Lima AP, Steverding D. Source Sandler Center for Drug Discovery, California Institute for Quantitative Biosciences, Byers Hall, University of California San Francisco, San Francisco, USA, caffrey@cgl.ucsf.edu. Abstract We review Clan CA Family C1 peptidases of kinetoplastid parasites (Trypanosoma and Leishmania) with respect to biochemical and genetic diversity, genomic organization and stage-specificity and control of expression. We discuss their contributions to parasite metabolism, virulence and pathogenesis and modulation of the host's immune response. Their applications as vaccine candidates and diagnostic markers as well as their chemical and genetic validation as drug targets are also summarized.
	PMID: 21660660 [PubMed - in process]

2.	Trends Parasitol. 2011 Jun 7. [Epub ahead of print] Diagnosis of human sleeping sickness: sense and sensitivity. Wastling SL, Welburn SC. Source Centre for Infectious Diseases, Division of Pathway Medicine, School of Biomedical Sciences, College of Medicine & Veterinary Medicine, The University of Edinburgh, The Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. Abstract In 1997 the World Health Organization (WHO) advocated increased access to diagnosis and treatment, as well as reinforcement of surveillance, for the control of sleeping sickness (human African trypanosomiasis, HAT). This coincided with the end of decades of civil conflicts in several endemic regions and negotiation of a sustainable supply of 'free' curative drugs and, as a result, HAT is at its lowest level in 50 years. However, reported cases underestimate prevalence and downplay HAT when compared with data generated by advanced diagnostic capacity for human immunodeficiency virus (HIV), tuberculosis (TB) and malaria, and, because HAT case numbers fall between epidemics, diagnostics become less commercially appealing. Here recent trends in the development of diagnostics for sleeping sickness are considered and progress towards a much-needed sensitive, specific and affordable point-of-care diagnostic is assessed. Copyright © 2011 Elsevier Ltd. All rights reserved.
	PMID: 21659003 [PubMed - as supplied by publisher]

3.	J Infect. 2011 May 20. [Epub ahead of print] Mucosal Leishmania infantum leishmaniasis: Specific pattern in a multicentre survey and historical cases. Faucher B, Pomares C, Fourcade S, Benyamine A, Marty P, Pratlong L, Faraut F, Mary C, Piarroux R, Dedet JP, Pratlong F. Source Laboratoire de Parasitologie et Mycologie, Centre Hospitalo-Universitaire de la Timone, Assistance Publique-Hôpitaux de Marseille (AP-HM), 13385 Marseille, France; Université de la Méditerrannée, UMR MD3, Marseille, France. Abstract OBJECTIVE: Leishmaniainfantum mucosally restricted leishmaniasis was rarely reported, so that diagnostic and treatment strategies remain debated. A long-term multicentric survey appeared thereby necessary. METHODS: Cases were prospectively collected over 12 years in 3 academic hospitals of Southern France. Predisposing factors, clinical findings, diagnostic procedures, treatment and outcome were compared to medical literature. RESULTS: Ten new cases and 40 historical reports were collected. Respectively 10/10 and 35/40 patients were adult males. Immunodeficiency was frequent (5/10 and 18/40). No previous cutaneous lesion was reported. Leishmaniasis affected mostly larynx (5/10 and 19/40), but also mouth (2/10 and 19/40) and nose (3/10 and 5/40). Lesions were highly polymorph. Mucosa histological examination provided respectively 1/10 and 2/40 false negative results, contrary to serum immunoblotting and PCR on mucosal biopsy. Although local response was always satisfactory even using topical treatment, subsequent visceral spreading was observed in 2/10 and 1/40 cases. CONCLUSION: L. infantum mucosally restricted leishmaniasis exhibits a specific pattern, marked by tropism for adult males, high clinical and histological polymorphism. Immunoblot screening and PCR confirmation of suspected lesions are necessary because of direct examination occasional false negative results. The risk of visceral spreading sustains systemic therapy. SUMMARY: Leishmania infantum mucosal leishmaniasis mostly affects adult males, half of them immunodeficient. Clinical and histological polymorphism makes the diagnosis difficult, stressing the need for immunoblot screening and mucosa PCR analysis of suspected cases. Possible visceralization sustains systemic therapy. Copyright © 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
	PMID: 21658772 [PubMed - as supplied by publisher]

4.	Microbes Infect. 2011 May 27. [Epub ahead of print] Diversity of response to Trypanosoma brucei gambiense infections in the Forecariah mangrove focus (Guinea): perspectives for a better control of sleeping sickness. Ilboudo H, Jamonneau V, Camara M, Camara O, Dama E, Léno M, Ouendeno F, Courtin F, Sakande H, Sanon R, Kaboré J, Coulibaly B, N'dri L, Diarra A, N'goran E, Bucheton B. Source Centre International de Recherche-Développement sur l'Elevage en zone Subhumide (CIRDES), 01 BP 454 Bobo-Dioulasso 01, Burkina Faso; Institut de Recherche pour le Développement, Unité Mixte de Recherche IRD-CIRAD 177, Campus International de Baillarguet, 34398 Montpellier Cedex 5, France. Abstract At a time when human African trypanosomiasis (HAT) elimination again seems a reachable goal in many parts of sub-Saharan Africa, it is becoming increasingly important to characterise the factors involved in disease resurgence or maintenance to develop sustainable control strategies. In this study conducted in the Forecariah mangrove focus in Guinea, HAT patients and serological suspects (SERO) were identified through mass screening of the population with the Card Agglutination Test for Trypanosomiasis (CATT) and were followed up for up to 2 years. Analysis of the samples collected during the follow-up of HAT patients and SERO was performed with PCR (TBR1/TBR2) and the trypanolysis serological test (TL) in order to clarify the role played by these individuals in the epidemiology of HAT. PCR positivity was higher in TL(+) than in SERO TL(-) (50% vs. 18%, respectively). Whereas CATT plasma titres decreased both in treated HAT patients and SERO TL(-), SERO TL(+) maintained high CATT titres. Four out of 17 SERO TL(+) developed HAT during the study. These results strongly suggest that SERO TL(+) individuals are asymptomatic carriers. In the context where disease prevalence is sufficiently low, treating SERO TL(+) individual may thus be of crucial importance in order to cut transmission. Copyright © 2011. Published by Elsevier SAS.
	PMID: 21658462 [PubMed - as supplied by publisher]

5.	Clin Lab Sci. 2011 Spring;24(2):85-8. Trypanosoma brucei infection in a HIV positive Ugandan male. Dill EA, Renault C, Kirkpatrick BD. Source University of Vermont, 95 Carrigan Drive, Burlington, VT 05405, USA. Elizabeth.Dill@uvm.edu Abstract Human African Trypanosomiasis, or African Sleeping Sickness, is a parasitic infection caused by Trypanosoma brucei (gambiense or rhodesiense), and one of the declared neglected tropical diseases. Sleeping sickness has high fatality rates and is a continued threat in several African countries. We present characteristic clinical and microbiologic features of a fatal case of African Sleeping Sickness in an HIV-infected individual.
	PMID: 21657140 [PubMed - in process]