What's new for 'Trypanosomatids' in PubMed

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Sent on Saturday, 2011 Jul 23
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results

Items 1 - 10 of 11

1.	Rev Soc Bras Med Trop. 2011 Jun;44(3):386-8. [Control of visceral leishmaniasis in the town of Porteirinha, state of Minas Gerais, Brazil, from 1998 to 2003]. [Article in Portuguese] Barata RA, Silva JC, Silva JC, Almeida SN, Teixeira Lde A, Dias ES. Source Laboratório de Parasitologia, Departamento de Ciências Biológicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG. Abstract INTRODUCTION: In the town of Porteirinha, State of Minas Gerais, 23 human cases of visceral leishmaniasis (VL) in 1998 and 1999 were recorded. METHODS: A study was conducted involving the triad of action recommended for the control of VL. Patients were treated and serologically positive dogs were euthanized quarterly. The pyrethroid insecticide α-cypermethrin was applied in the neighborhoods where human cases were recorded. RESULTS: A reduction in canine seroprevalence and sand flies occurred following the implementation of control measures, reflecting in a reduction in human cases of VL. CONCLUSIONS: The results show the efficiency of such control measures when used in association.
	PMID: 21779679 [PubMed - in process]

2.	Am J Dermatopathol. 2011 Aug;33(6):642-4. Cutaneous leishmaniasis with pseudoepitheliomatous hyperplasia simulating squamous cell carcinoma. Quintella LP, Cuzzi T, de Fátima Madeira M, Valete-Rosalino CM, de Matos Salgueiro M, de Camargo Ferreira E Vasconcellos E, Mouta-Confort E, Lambert Passos SR, de Oliveira Schubach A. Source Instituto de Pesquisa Clínica Evandro Chagas (IPEC), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brasil.
	PMID: 21778837 [PubMed - in process]

3.	Nature. 2010 Jun 24;465(7301):S8-9. Who, how, what and where? [No authors listed]
	PMID: 20571555 [PubMed - indexed for MEDLINE]
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4.	Nature. 2010 Jun 24;465(7301):S6-7. Chagas disease: a new worldwide challenge. Coura JR, Viñas PA. Source Federal University of Rio de Janeiro, Brazil. coura@ioc.fiocruz.br
	PMID: 20571554 [PubMed - indexed for MEDLINE]
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5.	Nature. 2010 Jun 24;465(7301):S4-5. Chagas disease 101. Clayton J.
	PMID: 20571553 [PubMed - indexed for MEDLINE]
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6.	Nature. 2010 Jun 24;465(7301):S18-20. Chagas disease in the Chaco. Petherick A.
	PMID: 20571550 [PubMed - indexed for MEDLINE]
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7.	Nature. 2010 Jun 24;465(7301):S16-7. The promise of T. cruzi genomics. Clayton J.
	PMID: 20571549 [PubMed - indexed for MEDLINE]
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8.	Nature. 2010 Jun 24;465(7301):S12-5. Chagas disease: pushing through the pipeline. Clayton J .
	PMID: 20571548 [PubMed - indexed for MEDLINE]
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9.	Med Trop (Mars). 2011 Apr;71(2):131-3. [Nifurtimox, a bright future for treatment of Chagas disease]. [Article in French] Wolf A, Boulliat C, Coillot C, Rouault M, Gaillard K, Beranger C, Oliver M. Source Service de Pharmacie Hspitalière. Hôpital d'lnstruction des Armées Laveran, Marseille. Abstract Nifurtimox is one of the two molecules used for treatment of Chagas disease. Although posology has not yet been clearly defined, nifurtimox is increasingly used, especially in combination with eflonithin. Nifurtimox is perfectly suited to the WHO's Chagas disease eradication program.
	PMID: 21695868 [PubMed - indexed for MEDLINE]
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10.	Protein J. 2011 Mar;30(3):212-9. Identification, molecular and functional characterization of calmodulin gene of Phytomonas serpens 15T that shares high similarity with its pathogenic counterparts Trypanosoma cruzi. de Souza Tde A, Graça-de Souza VK, Lancheros CA, Monteiro-Góes V, Krieger MA, Goldenberg S, Yamauchi LM, Yamada-Ogatta SF. Source Departamento de Microbiologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, PR 445, Km 380, Londrina, Paraná CEP 86051-980, Brazil. Abstract In trypanosomatids, Ca²+-binding proteins can affect parasite growth, differentiation and invasion. Due to their importance for parasite maintenance, they become an attractive target for drug discovery and design. Phytomonas serpens 15T is a non-human pathogenic trypanosomatid that expresses important protein homologs of human pathogenic trypanosomatids. In this study, the coding sequence of calmodulin, a Ca²+-binding protein, of P. serpens 15T was cloned and characterized. The encoded polypeptide (CaMP) displayed high amino acid identity to homolog protein of Trypanosoma cruzi and four helix-loop-helix motifs were found. CaMP sequence analysis showed 20 amino acid substitutions compared to its mammalian counterparts. This gene is located on a chromosomal band with estimated size of 1,300 kb and two transcripts were detected by Northern blot analysis. A polyclonal antiserum raised against the recombinant protein recognized a polypeptide with an estimated size of 17 kDa in log-phase promastigote extracts. The recombinant CaMP retains its Ca²+-binding capacity.
	PMID: 21431874 [PubMed - indexed for MEDLINE]
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