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Sent on Tuesday, 2012 January 03Search: kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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| PubMed Results |
| 1. | Vaccine. 2011 Dec 27. [Epub ahead of print]Comparative assessment of a DNA and protein Leishmania donovani gamma glutamyl cysteine synthetase vaccine to cross-protect against murine cutaneous leishmaniasis caused by L. major or L. mexicana infection.Campbell SA, Alawa J, Doro B, Henriquez FL, Roberts CW, Nok A, Alawa CB, Alsaadi M, Mullen AB, Carter KC.SourceSchool of Life, Sport and Social Sciences, Edinburgh Napier University, Edinburgh, UK. AbstractLeishmaniasis is a major health problem and it is estimated that 12 million people are currently infected. A vaccine which could cross-protect people against different Leishmania spp. would facilitate control of this disease as more than one species of Leishmania may be present. In this study the ability of a DNA vaccine, using the full gene sequence for L. donovani gamma glutamyl cysteine synthetase (γGCS) incorporated in the pVAX vector (pVAXγGCS), and a protein vaccine, using the corresponding recombinant L. donovani γGCS protein (LdγGCS), to protect against L. major or L. mexicana infection was evaluated. DNA vaccination gave transient protection against L. major and no protection against L. mexicana despite significantly enhancing specific antibody titres in vaccinated infected mice compared to infected controls. Vaccination with the LdγGCS protected against both species but only if the protein was incorporated into non-ionic surfactant vesicles for L. mexicana. The results of this study indicate that a L. donovani γGCS vaccine could be used to vaccinate against more than one Leishmania species but only if the recombinant protein is used. Copyright © 2011. Published by Elsevier Ltd. |
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| 2. | Exp Parasitol. 2011 Dec 22. [Epub ahead of print]Trypanosoma rangeli expresses a β-galactofuranosyl transferase.Stoco PH, Aresi C, Lückemeyer DD, Sperandio MM, Sincero TC, Steindel M, Miletti LC, Grisard EC.SourceDepartamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-970, Brazil. AbstractGlycoconjugates play essential roles in cell recognition, infectivity and survival of protozoan parasites within their insect vectors and mammalian hosts. β-Galactofuranose is a component of several glycoconjugates in many organisms, including a variety of trypanosomatids, but is absent in mammalian and African trypanosomes. Herein, we describe the presence of a β(1-3) galactofuranosyl transferase (GALFT), an important enzyme of the galactofuranose biosynthetic pathway, in Trypanosoma rangeli. The T. rangeli GALFT gene (TrGALFT) has an ORF of 1.2Kb and is organized in two copies in the T. rangeli genome. Antibodies raised against an internal fragment of the transferase demonstrated a 45kDa protein coded by TrGALFT was localized in the whole cytoplasm, mainly in the Golgi apparatus and equally expressed in epimastigotes and trypomastigotes from T. rangeli. Despite the high sequence similarity with Trypanosoma cruzi and Leishmania spp. orthologous TrGALFT showed a substitution of the metal-binding DXD motif, conserved amongst glycosyltransferases, for a DXE functionally analogous motif. Moreover, a reduced number of GALFT genes were present in T. rangeli when compared with other pathogenic kinetoplastid species. Copyright © 2011 Elsevier Inc. All rights reserved. |
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| 3. | Pediatr Infect Dis J. 2011 Dec 29. [Epub ahead of print]Acute Kidney Injury in Children with Visceral Leishmaniasis.Libório AB, Rocha NA, Oliveira MJ, Franco LF, Aguiar GB, Pimentel RS, Abreu KL, Silva GB Júnior, Daher EF.Source1Post-Graduate Program in Public Health, University of Fortaleza. Fortaleza, Ceará, Brazil. 2Division of Nephrology, Department of Internal Medicine, School of Medicine, Federal University of Ceará. Fortaleza, Ceará, Brazil. 3School of Medicine, Health Sciences Center, University of Fortaleza. Fortaleza, Ceará, Brazil. AbstractBACKGROUND:There is no comprehensive study about renal function in children with visceral leishmaniasis (VL). The aim of this study was to investigate the incidence of acute kidney injury (AKI) in children with VL using pRIFLE classification and to determine the risk factors for AKI. METHODS:A retrospective cohort study with 146 patients younger than 14 years-old with VL diagnosis in one center from the northeast of Brazil from December 2003 to 2010. AKI was evaluated by pRIFLE criteria. RESULTS:The mean age was 5±4.0 years (range 5 months to 14 years), and 53.4% were males. AKI was observed in 67 patients (45.9%). The distribution according to the pRIFLE criteria was as follows: Risk 45(67.2%), Injury 21(31.3%) and Failure 1(1.5%). Patients in the AKI group were significantly younger (p<0.001), had jaundice (p = 0.028) and secondary infections (p = 0.001) more often than non-AKI patients. The AKI group had a significantly lower serum sodium (p=0.03), potassium (p=0.009), serum albumin (p=0.001) and elevated serum globulins (p=0.04) and a more prolonged prothrombin time (p=0.001) at admission. Independent risk factors for AKI were: secondary infections (OR: 3.65, 95% CI: 1.426-9.358, p=0.007), serum albumin decrement (OR: 1.672, 95% CI: 1.065-2.114, p=0.019 per each 1 mg dL serum albumin decrement), and high serum globulin (OR: 1.35, 95% CI: 1.031-1.779, p=0.029 per each 1 mg dL serum globulin increment). CONCLUSIONS:Acute kidney injury is a frequent complication in children with VL. The risk factors for AKI were secondary infections, high serum globulin and low serum albumin. Keywords: Visceral Leishmaniasis; Kala-azar; AKI; pRIFLE. |
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| 4. | Eur J Radiol. 2011 Dec 28. [Epub ahead of print]MRI-findings of nodular lesions in an enlarged spleen, associated with visceral Leishmaniasis.Raeymaeckers S, Docx M, Demeyere N.SourceZNA Middelheim, Lindendreef 1, 2020 Antwerpen, Belgium. AbstractWe present a case of a 15-month-old Moroccan girl with fever of unknown origin, hepatosplenomegaly and multiple hypoechoic nodular splenic lesions that appear hypodense on CT. T2-weighted MRI sequences show a markedly inhomogeneous intensity of the parenchyma, seemingly caused by multiple ill-defined and heterogeneous hypointense nodules. Laboratory tests confirmed a recent infection with Leishmania, a parasite endemic to (sub)tropic regions. During and after therapy these lesions gradually resolved. To our knowledge this is the second published case in which different imaging modalities were able to demonstrate organ lesions associated with Leishmania. It is also the first report of MRI-findings associated with these lesions. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
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