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Sent on Saturday, 2012 March 17Search: kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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| PubMed Results |
| 1. | Hautarzt. 2012 Mar;63(3):233-49.[Cutaneous leishmaniasis as travelers' disease : Clinical presentation, diagnostics and therapy]. [Article in German] von Stebut E, Schleicher U, Bogdan C.SourceHautklinik, Universitätsmedizin Mainz, Johannes Gutenberg Universität, Langenbeckstr. 1, 55131, Mainz, Deutschland, vonstebu@mail.uni-mainz.de. AbstractLeishmaniasis is a disease with worldwide increasing incidence, which in Germany is almost exclusively observed in patients who have travelled to classical endemic regions such as the Mediterranean basin. Cause of the disease is an infection with protozoan parasites of the genus Leishmania, which are transmitted by sand flies and replicate intracellularly within mammalian hosts. Depending on the inoculated parasite (sub-) species and the immune status of the host, a local cutaneous, diffuse cutaneous, mucocutaneous or visceral form of leishmaniasis will develop. Cutaneous leishmaniasis, which frequently appears only weeks after the bite of a sand fly, starts with the formation of a papule, which subsequently can turn into a skin ulcer. The latter may heal spontaneously after months leaving behind a scar or persist as chronic, non-healing cutaneous leishmaniasis. If cutaneous leishmaniasis is suspected, a sterile skin biopsy followed by appropriate diagnostic measures in a specialized laboratory to identify the pathogen should be performed. For the decision on the type of therapy, several clinical parameters (e.g. number and localization of lesions, immune status) and, most importantly, the underlying parasite (sub-) species need to be considered. Therapy can consist of a variety of topical measures or systemic drug treatment. A modern and safe vaccine does not yet exist. |
| PMID: 22422121 [PubMed - in process] | |
| 2. | Dis Aquat Organ. 2012 Jan 24;97(3):227-35.Azumiobodo hoyamushi gen. nov. et sp. nov. (Euglenozoa, Kinetoplastea, Neobodonida): a pathogenic kinetoplastid causing the soft tunic syndrome in ascidian aquaculture.Hirose E, Nozawa A, Kumagai A, Kitamura S.SourceDepartment of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan. AbstractWe used morphological and genetic analyses to investigate a pathogenic kinetoplastid isolated from a diseased edible ascidian Halocynthia roretzi with soft tunic syndrome. The morphological characteristics of the kinetoplastid are similar to those in the order Neobodonida in the subclass Metakinetoplastida. However, the presence of unique globular bodies distinguishes this kinetoplastid from the other polykinetoplastic genera (i.e. Cruzella, Dimastigella and Rhynchobodo) in this order. These globular bodies are cytoplasmic inclusions without an outer delimiting membrane and are composed of a homologous granular matrix containing electron-dense bands. A phylogenetic tree based on 18S rRNA gene sequences also indicated that the kinetoplastid belongs to the order Neobodonida, although it forms an independent clade in this order. From these results, we propose a new genus in the order Neobodonida, i.e. Azumiobodo gen. nov., and Azumiobodo hoyamushi as the type species for the genus. |
| PMID: 22422093 [PubMed - in process] | |
| 3. | Dalton Trans. 2012 Mar 15. [Epub ahead of print]Synthesis and biological activity of cymantrene and cyrhetrene 4-aminoquinoline conjugates against malaria, leishmaniasis, and trypanosomiasis.Glans L, Hu W, Jöst C, de Kock C, Smith PJ, Haukka M, Bruhn H, Schatzschneider U, Nordlander E.SourceInorganic Chemistry Research Group, Chemical Physics, Center for Chemistry and Chemical Engineering, Lund University, Box 124, SE-221 00 Lund, Sweden. Ebbe.Nordlander@chemphys.lu.se. AbstractOrganometallic analogues of chloroquine show promise as new antimalarial agents capable of overcoming resistance to the parent drug chloroquine. Here, the synthesis and characterization of three new cymantrene (CpMn(CO)(3)) and cyrhetrene (CpRe(CO)(3)) 4-aminoquinoline conjugates with either an amine or amide linker are reported. The antimalarial activity of the new organometallic conjugates N-(2-(7-chloroquinolin-4-ylamino)ethyl)-4-cymantrenylbutanamide (), N-(2-(7-chloroquinolin-4-ylamino)ethyl)-4-cyrhetrenylbutanamide () and N-(7-chloroquinolin-4-yl)-N'-(cymantrenylmethyl)ethane-1,2-diamine () was evaluated against a chloroquine-sensitive (CQS) and a chloroquine-resistant strain (CQR) of the malaria parasite Plasmodium falciparum. The cymantrene complex with an amine linker () showed good activity against the CQS strain but was inactive against the CQR strain. In contrast, cymantrene and cyrhetrene compounds with an amide linker were active against both the CQS and the CQR strain. In addition, the antibacterial, anti-trypanosomal and anti-leishmanial activity of the compounds was evaluated. Compound showed submicromolar activity against Trypanosoma brucei at a concentration where the toxicity to normal human cells is low. No significant effect was noticed on the exchange of manganese for rhenium in the CpM(CO)(3) moiety in any of the biological assays. |
| PMID: 22421887 [PubMed - as supplied by publisher] | |
| 4. | Microbes Infect. 2012 Feb 28. [Epub ahead of print]Phenotyping of circulating CD8(+) T cell subsets in human cutaneous leishmaniasis.Khamesipour A, Rostami MN, Tasbihi M, Mohammadi AM, Shahrestani T, Sarrafnejad A, Sohrabi Y, Eskandari SE, Valian HK.SourceCenter for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, P.O. Box 14155-6383, Tehran, Iran. AbstractRecovery from CL is usually accompanied with long-lasting protection and induction of strong immune response. The phenotypes, generation and maintenance of central (=T(CM)) and effector (=T(EM)) memory T cell subsets in human leishmaniasis are not well known. Profile of T cell subsets were analyzed on peripheral CD8(+) T cells from volunteers with history of cutaneous leishmaniasis (HCL). In HCL and control groups, mean frequencies of CCR7(+)CD45RA(+)CD8(+) naïve and CCR7(-)CD45RA(-)CD8(+) T(EM) cells were higher than other subsets before culture, but after stimulation with soluble Leishmania antigen, the frequency of naïve T cells was significantly decreased and the frequency of T(EM) cells was significantly increased. T(EM) phenotype composed the highest portion of proliferating Carboxy Fluorescein diacetate Succinimidyl Ester (CFSE)-dim population which was significantly higher in HCL volunteers than in control group. Stimulation of isolated CD8(+) memory T cells, but not naïve T cells, from HCL volunteers induced a significantly higher IFN-γ production compared with that of healthy controls. Intracellular IFN-γ staining provided the same result. Memory population is shown to be responsible for Leishmania-induced IFN-γ production. Leishmania-reactive proliferating T(EM) cells were identified as the most frequent subset which may play a role in recall immune response and protection against Leishmania infection. Copyright © 2012. Published by Elsevier Masson SAS. |
| PMID: 22421108 [PubMed - as supplied by publisher] | |
| 5. | Nature. 2012 Feb 8;482(7384):167-9. doi: 10.1038/482167a.Infectious disease: Genomics decodes drug action.Fairlamb AH.Comment on |
| PMID: 22318598 [PubMed - indexed for MEDLINE] | |
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| 6. | Cell Cycle. 2011 Jul 15;10(14):2251. Epub 2011 Jul 15.That's amore: bone marrow cells compete for the heart in Chagas disease.Perrin MA.Comment on |
| PMID: 21750402 [PubMed - indexed for MEDLINE] | |
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| 7. | Acta Trop. 2011 Oct-Nov;120(1-2):59-66. Epub 2011 Jun 28.Sequence analysis of the spliced-leader intergenic region (SL-IR) a nd random amplified polymorphic DNA (RAPD) of Trypanosoma rangeli strains isolated from Rhodnius ecuadoriensis, R. colombiensis, R. pallescens and R. prolixus suggests a degree of co-evolution between parasites and vectors.Urrea DA, Guhl F, Herrera CP, Falla A, Carranza JC, Cuba-Cuba C, Triana-Chávez O, Grisard EC, Vallejo GA.SourceLaboratorio de Investigaciones en Parasitología Tropical-LIPT, Universidad del Tolima, AA 546, Altos de Santa Helena, Ibagué, Colombia. AbstractSpliced leader intergenic region (SL-IR) sequences from 23 Trypanosoma rangeli strains isolated from the salivary glands of Rhodnius colombiensis, R. ecuadoriensis, R. pallescens and R. prolixus and two human strains revealed the existence of 4 genotypes with CA, GT, TA, ATT and GTAT microsatellite repeats and the presence of insertions/deletions (INDEL) and single nucleotide polymorphism (SNP) characterizing each genotype. The strains isolated from the same vector species or the same Rhodnius evolutionary line presented the same genotypes, even in cases where strains had been isolated from vectors captured in geographically distant regions. The dendrogram constructed from the SL-IR sequences separated all of them into two main groups, one with the genotypes isolated from R. prolixus and the other group containing three well defined sub-groups with the genotypes isolated from R. pallescens, R. colombiensis and R. ecuadoriensis. Random amplified polymorphic DNA (RAPD) analysis showed the same two main groups and sub-groups supporting strict T. rangeli genotypes' association with Rhodnius species. Combined with other studies, these results suggest a possible co-evolutionary association between T. rangeli genotypes and their vectors. Copyright © 2011 Elsevier B.V. All rights reserved. |
| PMID: 21718675 [PubMed - indexed for MEDLINE] | |
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| 8. | Cell Cycle. 2011 Jul 1;10(13):2054. Epub 2011 Jul 1.Gene profiling for assessment of cell-based therapies.Engman DM.Comment on |
| PMID: 21701260 [PubMed - indexed for MEDLINE] | |
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| 9. | Cell Cycle. 2011 Jul 15;10(14):2250. Epub 2011 Jul 15.Resetting gene expression in chronic Chagas heart disease.Barcelos LS, Teixeira MM.Comment on |
| PMID: 21670589 [PubMed - indexed for MEDLINE] | |
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| 10. | Org Biomol Chem. 2011 Jun 21;9(12):4487-97. Epub 2011 Apr 28.Sialic acid C-glycosides with aromatic residues: investigating enzyme binding and inhibition of Trypanosoma cruzi trans-sialidase.Meinke S, Schroven A, Thiem J.SourceUniversity of Hamburg, Faculty of Science, Department of Chemistry, Institute of Organic Chemistry, Martin-Luther-King Platz 6, 20146, Hamburg, Germany. AbstractSeveral α-configured C-sialosides were synthesised by cross metathesis and further synthetic derivatisation to obtain ligands for Trypanosoma cruzi trans-sialidase (TcTS), a key enzyme in Chagas disease. Affinities of these compounds to immobilised TcTS were measured by surface plasmon resonance (SPR). The K(D) values thus obtained are in the lower millimolar range and will be discussed. The results show the importance of addressing Tyr(119) and Trp(312) side chains of TcTS in target oriented ligand synthesis, since these amino acids constitute the acceptor binding region in the active site of TcTS. The best ligand showed a significant decrease of TcTS activity in a preliminary NMR based inhibition assay. |
| PMID: 21528140 [PubMed - indexed for MEDLINE] | |
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