What's new for 'Trypanosomatids' in PubMed

This message contains My NCBI what's new results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM).
Do not reply directly to this message.

Sender's message:

Sent on Thursday, 2012 April 26
Search: kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"

Click here to view complete results in PubMed (Results may change over time.)
To unsubscribe from these e-mail updates click here.

PubMed Results

Items 1 - 6 of 6

1.	Hautarzt. 2012 Apr 26. [Epub ahead of print] [Vacation and tropical dermatoses.] [Article in German] Fischer M, Reinel D. Source Abteilung Dermatologie, Venerologie und Allergologie und Fachbereich Tropenmedizin am Bernhard-Nocht-Institut, Bundeswehrkrankenhaus Hamburg, Lesserstr. 180, 22049, Hamburg, Deutschland, Fischer@bni-hamburg.de. Abstract Besides fever and diarrhea, skin diseases are the third most common cause of morbidity in returning travelers after a stay in a tropical country. Approximately one- quarter of these dermatological symptoms can be referred to a classical tropical disease. The majority are of infectious origin. Often only the clinical appearance leads to the diagnosis of a tropical disease as myiasis, cutaneous larva migrans, tungiasis or cutaneous leishmaniasis. Not infrequently the dermatological symptoms lead to the diagnosis of a primarily systemic tropical disease. For example, an eschar with or without a rash might lead to the diagnosis of a South African tick bite fever caused by Rickettsia africae days before serology may turn positive. Less common tropical skin diseases such as lymphatic filariasis and loiasis need to be considered in returning long-term travelers and immigrants.
	PMID: 22532262 [PubMed - as supplied by publisher]
	Related citations

2.	J Travel Med. 2012 May;19(3):158-162. doi: 10.1111/j.1708-8305.2012.00611.x. Profile of Travel-Associated Illness in Children, Zürich, Switzerland. Hunziker T, Berger C, Staubli G, Tschopp A, Weber R, Nadal D, Hatz C, Schlagenhauf P. Source University of Zürich Centre for Travel Medicine, World Health Organisation Collaborating Centre for Travellers' Health, University of Zürich, Zürich, Switzerland Division of Infectious Diseases, University of Zürich Children's Hospital, Zürich, Switzerland Emergency Department, Division of Infectious Diseases, University of Zürich Children's Hospital, Zürich, Switzerland Division of Biostatistics, Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland Division of Infectious Diseases, University Hospital Zürich, Zürich, Switzerland. Abstract Background. The number of families traveling with their children to their country of origin and/or to tropical destinations has increased in Switzerland and includes a changing profile and multinational range of patients. Defining the profile of reported travel-associated illnesses will help to improve the prevention and treatment of such illnesses in children. Methods. This study includes children aged up to 16 years who sought medical advice for a presumed travel-related illness at the emergency room of the University of Zürich Children's Hospital during the period July 2007 to December 2008. Results. We analyzed data on 328 children (58.8% male, mean age: 4.62 y) who presented with travel-associated illness. Our analysis included 155 traditional (mainly tourist) travelers, 162 children who were visiting friends and relatives (VFR), and 11 immigrants. Some 11% were hospitalized. No deaths occurred. The main conditions recorded were diarrheal illness (39%), respiratory (28.7%) and febrile/systemic illness (13.4%). With increasing age, the proportion of children with diarrheal disease increased, while the proportion with respiratory illness declined. There were significant associations between geographic area of exposure and the profile of travel-related disease (p < 0.001). Among 36 children with more serious diseases requiring hospitalization, 12 (3.7% overall) presented with potentially serious diseases: malaria (n = 2), Salmonella typhi (n = 3), Salmonella paratyphi (n = 2), meningococcal meningitis (n = 1), tuberculosis (n = 2), visceral leishmania (n = 1), and hepatitis A (n = 1). Eleven of the 12 children presenting with these potentially serious illnesses were VFR or immigrant children. Conclusion. The main diagnoses for ill-returned Zürich children who presented for emergency care were diarrhea, respiratory, and febrile/systemic illness. A broad spectrum of morbidity was seen including meningococcal meningitis, malaria, tuberculosis, typhoid fever, leishmania, and hepatitis A. Diagnoses varied between geographic regions visited, and VFR child travelers constituted a large proportion of sick-returned children presenting for emergency care. © 2012 International Society of Travel Medicine.
	PMID: 22530822 [PubMed - as supplied by publisher]
	Related citations

3.	J Nat Prod. 2012 Apr 24. [Epub ahead of print] Antiprotozoal and Antimicrobial Compounds from the Plant Pathogen Septoria pistaciarum. Kumarihamy M, Khan SI, Jacob M, Tekwani BL, Duke SO, Ferreira D, Nanayakkara NP . Source National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and ⊥Department of Pharmacognosy, School of Pharmacy, The University of Mississippi , University, Mississippi 38677, United States. Abstract Four new 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids, 17-hydroxy-N-(O-methyl)septoriamycin A (1), 17-acetoxy-N-(O-methyl)septoriamycin A (2), 13-(S)-hydroxy-N-(O-methyl)septoriamycin A (3), and 13-(R)-hydroxy-N-(O-methyl)septoriamycin A (4), together with the known compounds (+)-cercosporin (5), (+)-14-O-acetylcercosporin (6), (+)-di-O-acetylcercosporin (7), lumichrome, and brassicasterol, were isolated from an ethyl acetate extract of a culture medium of Septoria pistaciarum. Methylation of septoriamycin A (8) with diazomethane yielded three di-O-methyl analogues, two of which existed as mixtures of rotamers. We previously reported antimalarial activity of septoriamycin A. This compound also exhibited significant activity against Leishmania donovani promastigotes. Compounds 5-7 showed moderate in vitro activity against L. donovani promastigotes and chloroquine-sensitive (D6) and -resistant (W2) strains of Plasmodium falciparum, whereas compound 5 was fairly active against methicillin-sensitive and methicillin-resistant strains of Staphylococcus aureus. Compounds 5-7 also displayed moderate phytotoxic activity against both a dicot (lettuce, Lactuca sativa) and a monocot (bentgrass, Agrostis stolonifera) and cytotoxicity against a panel of cell lines.
	PMID: 22530813 [PubMed - as supplied by publisher]
	Related citations

4.	Lakartidningen. 2011 Nov 16-22;108(46):2368-71. [Chagas' disease in Sweden--great need of guidelines for testing. Probably hundreds of seropositive cases, only a few known]. [Article in Swedish] Sandahl K, Botero-Kleiven S, Hellgren U. Source Karolinska institutet, Stockholm. katarina.sandahl@stud.ki.se
	PMID: 22468375 [PubMed - indexed for MEDLINE]
	Related citations

5.	Ann Trop Med Parasitol. 2011 Dec;105(8):651-4. Further characterization of Trypanosoma cruzi strains through a simple sequence repeat (SSR) of ferredoxin-NADP+ reductase 5' UTR. Jaeger LH, Brandao A. Source Oswaldo Cruz Institute, Rio de Janiero, RJ, Brazil.
	PMID: 22325824 [PubMed - indexed for MEDLINE]
	Related citations

6.	Ann Trop Med Parasitol. 2011 Dec;105(8):625-46. Geographical structuring of Trypanosoma cruzi populations from Chilean Triatoma infestans triatomines and their genetic relationship with other Latino American counterparts. Venegas J, Rojas T, Díaz F, Miranda S, Jercic MI, González C, Coñoepán W, Pichuantes S, Rodríguez J, Gajardo M, Sánchez G. Source Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile. jvenega@med.uchile.cl Abstract In order to obtain more information about the population structure of Chilean Trypanosoma cruzi, and their genetic relationship with other Latino American counterparts, we performed the study of T. cruzi samples detected in the midgut content of Triatoma infestans insects from three endemic regions of Chile. The genetic characteristics of these samples were analysed using microsatellite markers and PCR conditions that allow the detection of predominant T. cruzi clones directly in triatomine midgut content. Population genetic analyses using the Fisher's exact method, analysis of molecular variance (AMOVA) and the determination of F(ST) showed that the northern T. cruzi population sample was genetically differentiated from the two southern population counterparts. Further analysis showed that the cause of this genetic differentiation was the asymmetrical distribution of TcIII T. cruzi predominant clones. Considering all triatomines from the three regions, the most frequent predominant lineages were TcIII (38%), followed by TcI (34%) and hybrid (8%). No TcII lineage was observed along the predominant T. cruzi clones. The best phylogenetic reconstruction using the shared allelic genetic distance was concordant with the population genetic analysis and tree topology previously described studying foreign samples. The correlation studies showed that the lineage TcIII from the III region was genetically differentiated from the other two, and this differentiation was correlated with geographical distance including Chilean and mainly Brazilian samples. It will be interesting to investigate whether this geographical structure may be related with different clinical manifestation of Chagas disease.
	PMID: 22325822 [PubMed - indexed for MEDLINE]
	Related citations