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Sent on Thursday, 2009 Feb 26Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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| PubMed Results |
- 1: Proteins. 2009 Jan 20. [Epub ahead of print]
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Solution structure of Urm1 from Trypanosoma brucei.
Hefei National Laboratory for Physical Sciences at Microscale, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.
PMID: 19241476 [PubMed - as supplied by publisher]
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- Genetic diversity and population structure of Trypanosoma brucei: clonality versus sexuality. [Mol Biochem Parasitol. 1995]
- ReviewThe mitochondrial ATP synthase of Trypanosoma brucei: structure and regulation. [J Bioenerg Biomembr. 1994]
- ReviewThe transferrin receptor of Trypanosoma brucei. [Parasitol Int. 2000]
- 2: J Cell Sci. 2009 Feb 24. [Epub ahead of print]
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A novel function for the atypical small G protein Rab-like 5 in the assembly of the trypanosome flagellum.
The atypical small G protein Rab-like 5 has been shown to traffic in sensory cilia of Caenorhabditis elegans, where it participates in signalling processes but not in cilia construction. In this report, we demonstrate that RABL5 colocalises with intraflagellar transport (IFT) proteins at the basal body and in the flagellum matrix of the protist Trypanosoma brucei. RABL5 fused to GFP exhibits anterograde movement in the flagellum of live trypanosomes, suggesting it could be associated with IFT. Accordingly, RABL5 accumulates in the short flagella of the retrograde IFT140(RNAi) mutant and is restricted to the basal body region in the IFT88(RNAi) anterograde mutant, a behaviour that is identical to other IFT proteins. Strikingly, RNAi silencing reveals an essential role for RABL5 in trypanosome flagellum construction. RNAi knock-down produces a phenotype similar to inactivation of retrograde IFT with formation of short flagella that are filled with a high amount of IFT proteins. These data reveal for the first time a functional difference for a conserved flagellar matrix protein between two different ciliated species and raise questions related to cilia diversity.
PMID: 19240117 [PubMed - as supplied by publisher]
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Related Articles
- Intraflagellar transport and functional analysis of genes required for flagellum formation in trypanosomes. [Mol Biol Cell. 2008]
- Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons. [J Cell Biol. 1998]
- Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm. [Curr Biol. 2003]
- Review[The flagellum: from cell motility to morphogenesis] [J Soc Biol. 2003]
- ReviewIntramanchette transport (IMT): managing the making of the spermatid head, centrosome, and tail. [Mol Reprod Dev. 2002]
- 3: Med Vet Entomol. 2009 Mar;23(1):69-77.
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Population structure and geographical subdivision of the Leishmania major vector Phlebotomus papatasi as revealed by microsatellite variation.
Department of Biological Sciences, Al-Quds University, Jerusalem, Palestine.
Multi-locus microsatellite typing (MLMT) has been employed to infer the population structure of Phlebotomus papatasi (Scopoli) (Diptera: Psychodidae) sandflies and assign individuals to populations. Phlebotomus papatasi sandflies were collected from 35 sites in 15 countries. A total of 188 P. papatasi individuals were typed using five microsatellite loci, resulting in 113 different genotypes. Unique microsatellite signatures were observed for some of the populations analysed. Comparable results were obtained when the data were analysed with Bayesian model and distance-based methods. Bayesian statistic-based analyses split the dataset into two distinct genetic clusters, A and B, with further substructuring within each. Population A consisted of five subpopulations representing large numbers of alleles that were correlated with the geographical origins of the sandflies. Cluster B comprised individuals collected in the Middle East and the northern Mediterranean area. The subpopulations B1 and B2 did not, however, show any further correlation to geographical origin. The genetic differentiation between subpopulations was supported by F statistics showing statistically significant (Bonferroni-corrected P < 0.005) values of 0.221 between B2 and B1 and 0.816 between A5 and A4. Identification of the genetic structure of P. papatasi populations is important for understanding the patterns of dispersal of this species and to developing strategies for sandfly control.
PMID: 19239616 [PubMed - in process]
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- Mitochondrial and Wolbachia markers for the sandfly Phlebotomus papatasi: little population differentiation between peridomestic sites and gerbil burrows in Isfahan province, Iran. [Med Vet Entomol. 2003]
- DNA hybridizations on squash-blotted sandflies to identify both Phlebotomus papatasi and infecting Leishmania major. [Med Vet Entomol. 1988]
- Review[Prevention and control of leishmaniasis vectors: current approaches] [Parassitologia. 2004]
- ReviewNatural breeding places of phlebotomine sandflies. [Med Vet Entomol. 2004]
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