What's new for 'Trypanosomatids' in PubMed

This message contains My NCBI what's new results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM).
Do not reply directly to this message.

Sender's message:

Sent on Saturday, 2009 May 09
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
Click here to view complete results in PubMed. (Results may change over time.)
To unsubscribe from these e-mail updates click here.

PubMed Results

Items 1 -3 of 3

1: Biol Trace Elem Res. 2009 May 8. [Epub ahead of print]

Antimony Containing Drug and ECG Abnormalities in Children with Visceral Leishmaniasis.

Zanoni LZ, Brustoloni YM, Melnikov P, Cônsolo CE.

Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil, lzzanoni@yahoo.com.br.

The objective of the paper was to evaluate the influence of antimony (5(+)) on electrocardiographic changes in children with visceral leishmaniasis. The study was based on weekly ECGs analysis of 87 children treated, from April 2001 to May 2006, with antimoniate N-methyl glucamine. Eligible subjects included children from 6 months to 12 years of age with weight of 6-34 kg. Forty-five children (52%) were males and forty-two (48%) were females. The cardiac response to antimony was significantly milder compared to the adult populations, so the usage of meglumine antimoniate is safer. Thus, during treatment sinus rhythm was maintained without ectopic beats. No changes were observed in the P wave and in PR interval. The QRS complex remained unaltered during the treatment, the amplitude being increased. The Sokolow;s indexes exceeded normal values in one child on the first week and in eight children on the fourth. The prolongation of QTc occurred in ten patients. The T wave flattening was observed in seven children on the first week. In total, ECG abnormalities were detected in 34.4% of treatment courses, while in adults they were reported in 53.8%. Antimony therapy needs ECG monitoring of the cardiac function in order to prevent complications.

PMID: 19424667 [PubMed - as supplied by publisher]

Related articles

• Electrocardiographic changes during treatment of leishmaniasis with pentavalent antimony (sodium stibogluconate).

  Am J Trop Med Hyg. 1985 Jul; 34(4):702-9.

  [Am J Trop Med Hyg. 1985]

• Electrocardiographic findings in Ethiopians on pentavalent antimony therapy for visceral leishmaniasis.

  East Afr Med J. 2001 Nov; 78(11):608-10.

  [East Afr Med J. 2001]

• Pharmacokinetics of antimony in children treated for leishmaniasis with meglumine antimoniate.

  J Infect Dis. 2007 Feb 15; 195(4):602-8. Epub 2007 Jan 11.

  [J Infect Dis. 2007]

• Review[Treatment of visceral leishmaniasis in children]

  Med Trop (Mars). 2007 Feb; 67(1):73-8.

  [Med Trop (Mars). 2007]

• Review[Change in human visceral leishmaniasis treatment in Italy: retrospective study of 630 patients]

  Parassitologia. 2004 Jun; 46(1-2):199-201.

  [Parassitologia. 2004]

• » See reviews... | » See all...

2: Genes Dev. 2009 May 1;23(9):1037-41. LinkOut

Comment on:

Genes Dev. 2009 May 1;23(9):1063-76.

Chromatin-based transcriptional punctuation.

Talbert PB, Henikoff S.

Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. ptalbert@fhcrc.org

The long polycistronic transcription units of trypanosomes do not appear to be demarcated by the usual DNA motifs that punctuate transcription in familiar eukaryotes. In this issue of Genes & Development, Siegel and colleagues (pp. 1063-1076) describe a system for the demarcation of trypanosome transcription units based on the deposition and turnover of histone variants rather than on the binding of transcription factors. Replication-independent incorporation of histone variants and destabilization of nucleosomes is an emerging theme at promoters of more familiar eukaryotes, and it now appears that this system is an evolutionarily conserved mode of transcriptional punctuation.

PMID: 19417102 [PubMed - indexed for MEDLINE]

Related articles

• Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei.

  Genes Dev. 2009 May 1; 23(9):1063-76. Epub 2009 Apr 15.

  [Genes Dev. 2009]

• Isolation, characterisation and organisation of histone H1 genes in African trypanosomes.

  Parasitol Res. 2001 Dec; 87(12):977-84.

  [Parasitol Res. 2001]

• ReviewNuclear gene transcription and chromatin in Trypanosoma brucei.

  Int J Parasitol. 2001 Sep; 31(11):1157-65.

  [Int J Parasitol. 2001]

• Regulated processive transcription of chromatin by T7 RNA polymerase in Trypanosoma brucei.

  Nucleic Acids Res. 1998 Oct 15; 26(20):4626-34.

  [Nucleic Acids Res. 1998]

• ReviewComparative genomics of transcription factors and chromatin proteins in parasitic protists and other eukaryotes.

  Int J Parasitol. 2008 Jan; 38(1):1-31. Epub 2007 Sep 15.

  [Int J Parasitol. 2008]

• » See reviews... | » See all...

3: PLoS Med. 2009 Apr 14;6(4):e1000053. Epub 2009 Apr 14. References for this PMC Article, Free in PMC, LinkOut

Prolonged fever, hepatosplenomegaly, and pancytopenia in a 46-year-old woman.

Levy L, Nasereddin A, Rav-Acha M, Kedmi M, Rund D, Gatt ME.

Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. levyliran@hadassah.org.il

PMID: 19365537 [PubMed - indexed for MEDLINE]

PMCID: PMC2661247

Related articles

• [Fever, pancytopenia, and splenomegaly 8 months after a trip to Majorca Island (Spain)]

  Med Klin (Munich). 2008 Jan 15; 103(1):29-35.

  [Med Klin (Munich). 2008]

• [Visceral leishmaniasis (kala-azar). A rare differential diagnosis of splenomegaly and pancytopenia]

  Dtsch Med Wochenschr. 1989 Dec 1; 114(48):1876-81.

  [Dtsch Med Wochenschr. 1989]

• [Male child with prolonged fever, hepatosplenomegaly, pancytopenia and multisystemic alteration]

  An Pediatr (Barc). 2007 Jan; 66(1):107-9.

  [An Pediatr (Barc). 2007]

• Review[Visceral leishmaniasis. Personal observation and review of epidemiology, clinical aspects and therapy]

  Klin Padiatr. 1990 Sep-Oct; 202(5):347-51.

  [Klin Padiatr. 1990]

• Review[24-year-old male with fever, pancytopenia, and alterations in his state of consciousness]

  Rev Invest Clin. 1992 Apr-Jun; 44(2):259-60; discussion 260-7.

  [Rev Invest Clin. 1992]

• » See reviews... | » See all...

Patient Drug Information

• Cyclosporine (Neoral® , Sandimmune® , Gengraf® )

  Cyclosporine and cyclosporine (modified) are used with other medications to prevent transplant rejection (attack of the transplanted organ by the immune system of the person who received the organ) in people who have rec...

• Source: AHFS Consumer Medication Information