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Sent on Saturday, 2010 Jan 09Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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| PubMed Results |
| 1. | Vet Parasitol. 2009 Dec 22. [Epub ahead of print]Naturally acquired visceral leishmaniasis in non-human primates in Brazil.Malta MC, Tinoco HP, Xavier MN, Vieira AL, Costa EA, Santos RL.Fundação Zoo-Botânica de Belo Horizonte, Av. Otacílio Negrão de Lima 8000, 31365-450 Belo Horizonte, MG, Brazil. Visceral leishmaniasis (VL) is a chronic and often fatal protozoal disease that is endemic in Belo Horizonte (State of Minas Gerais, Brazil). Leishmania sp. is an intracellular obligatory parasite of macrophages that can naturally infect several mammalian species. Non-human primates (NHP) have been used as experimental models for infection with Leishmania of the donovani complex. The present report describes a case of visceral leishmaniasis in a black-fronted titi. Among 41 primates kept in captivity in a zoo in Belo Horizonte (State of Minas Gerais, Brazil), one animal, a black-fronted titi (Callicebus nigrifrons), was positive for Leishmania chagasi infection by PCR and immunohistochemistry, and developed a fatal disease with clinical signs and lesions compatible with VL. Other 17 NHP, including six black-fronted titis (C. nigrifrons), one howler monkey (Alouatta guariba), three golden-bellied capuchins (Cebus xanthosternos), one golden-headed lion tamarin (Leontopithecus crysomelas), one black-headed owl monkey (Aotus nigriceps), two Rio Tapajós sakis (Pithecia irrorata) and three emperor tamarins (Saguinus imperator) had blood samples that tested positive for amplification of Leishmania kDNA by PCR, although these NPH had no clinical signs of the disease. Copyright © 2009 Elsevier B.V. All rights reserved. |
| PMID: 20056328 [PubMed - as supplied by publisher] | |
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| 2. | Vaccine. 2010 Jan 4. [Epub ahead of print]Intranasal immunization with Leish-111f induces IFN-gamma production and protects mice from Leis hmania major infection.Sakai SI, Takashima Y, Matsumoto Y, Reed SG, Hayashi Y, Matsumoto Y.Laboratory of Global Animal Resource Science, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. The mucosal vaccination is a non-invasive alternative approach for not only mucosal pathogens but also parenteral pathogens, since it induces both mucosal and systemic immunoreactions. The purpose of this study was to evaluate the application of intranasal (i.n.) immunization with a recombinant leishmanial protein against Leishmania infection. BALB/c mice were i.n. administered 1-3 times with Leish-111f plus cholera toxin (CT) adjuvant (Leish-111f/CT). Splenocytes from i.n. immunized mice produced high level of IFN-gamma but not IL-4 in response to Leish-111f. When infected with 1x10(6) of Leishmania major promastigotes 2 weeks after the final administration, lesion development was completely controlled in all mice i.n. administered with Leish-111f/CT. Mice i.n. administered with Leish-111f alone showed neither cytokine productions nor lesion control even after 6 administrations, suggesting the importance of CT adjuvant. This report demonstrated for the first time that i.n. administration of a recombinant leishmanial protein induces Th1 type immunity and protects mice from Leishmania infection. Copyright © 2009. Published by Elsevier Ltd. |
| PMID: 20056184 [PubMed - as supplied by publisher] | |
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| 3. | J Proteomics. 2010 Jan 4. [Epub ahead of print]Proteomics of Trypanosomatids of Human Medical Importance.Cuervo P, Domont GB, De Jesus JB.Laboratorio de Pesquisa em Leishmaniose, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brasil. Leishmania spp., Trypanosoma cruzi, and Trypanosoma brucei are protozoan parasites that cause a spectrum of fatal human diseases around the world. Recent completion of the genomic sequencing of these parasites has enormous relevance to the study of their biology and the pathogenesis of the diseases they cause because it opens the door to high-throughput proteomic technologies. This review encompasses studies using diverse proteomic approaches with these organisms to describe and catalogue global protein profiles, reveal changes in protein expression during development, elucidate the subcellular localisation of gene products, and evaluate host-parasite interactions. Copyright © 2009. Published by Elsevier B.V. |
| PMID: 20056176 [PubMed - as supplied by publisher] | |
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| 4. | Biochim Biophys Acta. 2010 Jan 4. [Epub ahead of print]Purification and kinetic characterization of recombinant alternative oxidase from Trypanosoma brucei bruce i.Kido Y, Sakamoto K, Nakamura K, Harada M, Suzuki T, Yabu Y, Saimoto H, Yamakura F, Ohmori D, Moore A, Harada S, Kita K.Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. |
| PMID: 20056101 [PubMed - as supplied by publisher] | |
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| 5. | Clin Exp Dermatol. 2009 Dec;34(8):e889-91.Spontaneous cure of American cutaneous leishmaniasis due to Leishmania naiffi in two Dutch infantry soldiers.van der Snoek EM, Lammers AM, Kortbeek LM, Roelfsema JH, Bart A, Jaspers CA.Department of Dermatology, Military Hospital, Utrecht, The Netherlands. e.vandersnoek@erasmusmc.nl We report two Dutch infantry soldiers who acquired American cutaneous leishmaniasis (ACL) during military jungle training in Surinam. The lesions had existed for 3 and 5 months, respectively, before the soldiers presented for treatment. The lesions occurred on the head and right thigh, and were small, uncomplicated and symptomless. PCR for Leishmania revealed Leishmania naiffi in both patients. No treatment was given, and the lesions in both men healed spontaneously within 4 and 6 weeks, respectively, after presentation to our clinic. CL is one of the important 'tropical' diseases in The Netherlands, primarily due to the increasing numbers of cases in travellers and in military personnel serving overseas. ACL due to L. naiffi is thought to be a mild expression of CL with a self-limiting nature. Lesions seem to be single, mostly small, ulcerating and usually appear on the hands, arms and legs. No case of mucocutaneous leishmaniasis has yet been attributed to this parasite. |
| PMID: 20055858 [PubMed - in process] | |
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| 6. | Invest Clin. 2009 Sep;50(3):335-45.[Detection of Trypanosoma cruzi DNA in the placenta and fetuses of mice with Chagasic acute infection][Ar ticle in Spanish] Alarcón M, Pérez MC, Villarreal J, Araujo S, Goncalves L, González A, Moreno E, Lugo-Yarbuh A.Laboratorio de Parasitología Experimental (LAPEX), Facultad de Ciencias, Universidad de los Andes, Mérida, Venezuela. amaritza@ula.ve The objective of the present study was to detect the presence of Trypanosoma cruzi DNA in the placenta and fetal tissues of NMRI mice (Mus musculus) inoculated with 22 x 10(3) trypomastigotes metacyclic of the M/HOM/BRA/53/Y strain by intraperitoneal route. Mice were pregnant in the acute phase of the infection. The course of patent parasitemia by T. cruzi was evaluated before mating and during pregnancy. At day twenty of gestation, animals were sacrificed and the fetuses and their placentas were removed to evaluate T. cruzi infection. Samples of fetal placenta, heart and skeletal muscle were fixed in 10%, formalin, included in paraffin and stained with hematoxilin and eosin (HE). The histopathological study of sections of fetal tissues revealed inflammatory infiltrates with mononuclear and polymorphonuclear cells and without parasitism in these tissues. The amplification of T. cruzi DNA by Polymerase Chain Reaction (PCR) showed a positive reaction in 18% of placental tissue of pregnant infected mice. The samples of heart and skeletal muscle of the fetuses of mothers infected with T. cruzi did not show the presence T. cruzi DNA. The placenta and skeletal muscle of the fetuses analyzed by Peroxidase anti Peroxidase inmunostaining showed T. cruzi antigens in those tissues. Negative results by PCR in fetal tissues might be related with the virulence and tropism associated with the biological and genetic characteristic Of the T. cruzi strain used in the experimental infection of female mice. |
| PMID: 19961056 [PubMed - indexed for MEDLINE] | |
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