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Sent on Wednesday, 2010 Jan 20Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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| PubMed Results |
| 1. | Parasitol Res. 2010 Jan 19. [Epub ahead of print]Molecular identification of the parasites causing cutaneous leishmaniasis on the Caribbean coast of Colombia.Martínez LP, Rebollo JA, Luna AL, Cochero S, Bejarano EE.Grupo de Investigaciones Biomédicas, Universidad de Sucre, Cra. 14 No. 16B-32, A.A. 406, Sincelejo, Colombia. All clinical manifestations of leishmaniasis exist in Colombia, the cutaneous form being the most frequent in the department of Sucre, where the Leishmania species associated with cutaneous leishmaniasis (CL) is unknown. This study was carried out to determine which Leishmania species was responsible for CL in Sucre, based on amplification and sequencing of the Cyt b gene. Isolates of Leishmania were obtained after CL diagnosis of eight patients who received attention in several health care centers of the study area. The nucleotide sequences obtained from patients were compared to Leishmania reference strains and six of the isolates identified as Leishmania (Viannia) braziliensis, the remaining two being identified as Leishmania (Viannia) panamensis and Leishmania (Viannia) guyanensis. This represents the first report of the presence of L. (V.) guyanensis on the Caribbean coast of Colombia. |
| PMID: 20084397 [PubMed - as supplied by publisher] | |
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| 2. | PLoS Negl Trop Dis. 2010 Jan 12;4(1):e580.Leishmania major Glycosylation Mutants Require Phosphoglycans (lpg2) but Not Lipophosphoglycan (lpg1) for Survival in Permissive Sand Fly Vectors.Svárovská A, Ant TH, Seblová V, Jecná L, Beverley SM, Volf P.Department of Parasitology, Faculty of Science, Charles University in Prague, Czech Republic. BACKGROUND: Sand fly species able to support the survival of the protozoan parasite Leishmania have been classified as permissive or specific, based upon their ability to support a wide or limited range of strains and/or species. Studies of a limited number of fly/parasite species combinations have implicated parasite surface molecules in this process and here we provide further evidence in support of this proposal. We investigated the role of lipophosphoglycan (LPG) and other phosphoglycans (PGs) in sand fly survival, using Leishmania major mutants deficient in LPG (lpg1(-)), and the phosphoglycan (PG)-deficient mutant lpg2(-). The sand fly species used were the permissive species Phlebotomus perniciosus and P. argentipes, and the specific vector P. duboscqi, a species resistant to L. infantum development. PRINCIPAL FINDINGS: The lpg2(-) mutants did not survive well in any of the three sand fly species, suggesting that phosphoglycans and/or other LPG2-dependent molecules are required for parasite development. In vitro, all three L. major lines were equally resistant to proteolytic activity of bovine trypsin, suggesting that sand fly-specific hydrolytic proteases or other factors are the reason for the early lpg2(-) parasite killing. The lpg1(-) mutants developed late-stage infections in two permissive species, P. perniciosus and P. argentipes, where their infection rates and intensities of infections were comparable to the wild type (WT) parasites. In contrast, in P. duboscqi the lpg1(-) mutants developed significantly worse than the WT parasites. CONCLUSIONS: In combination with previous studies, the data establish clearly that LPG is not required for Leishmania survival in permissive species P. perniciosus and P. argentipes but plays an important role in the specific vector P. duboscqi. With regard to PGs other than LPG, the data prove the importance of LPG2-related molecules for survival of L. major in the three sand fly species tested. |
| PMID: 20084096 [PubMed - in process] | |
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| 3. | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6582-4. Epub 2009 Oct 13.Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib a s anti-Trypanosoma cruzi agents.Chennamaneni NK, Arif J, Buckner FS, Gelb MH.Department of Chemistry, University of Washington, Seattle, WA 98195, USA. We developed a synthetic route to prepare isoquinoline analogs of the cancer drug clinical candidate tipifarnib. We show that these compounds kill Trypanosoma cruzi amastigotes grown in mammalian host cells at concentrations in the low nanomolar range. These isoquinolines represent new leads for the development of drugs to treat Chagas disease. PMCID: PMC2783978 [Available on 2010/12/1] |
| PMID: 19875282 [PubMed - indexed for MEDLINE] | |
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| 4. | Mol Phylogenet Evol. 2010 Jan;54(1):243-53. Epub 2009 Oct 14.Probing into the dive rsity of trypanosomatid flagellates parasitizing insect hosts in South-West China reveals both endemism and global dispersal.Votýpka J, Maslov DA, Yurchenko V, Jirků M, Kment P, Lun ZR, Lukes J.Biology Centre, Institute of Parasitology, Ceské Budejovice (Budweis), Czech Republic. Flagellates of the class Kinetoplastea are known to frequently parasitize insects. We have collected 67 isolates from 407 Heteroptera hosts captured in several locations of South-West China. Their splice leader (SL) RNA gene repeats and small subunit (SSU) rRNA genes were PCR amplified from the infected tissue samples. In most cases, parasites were found in the midgut, rarely the infection was confined to the Malpighian tubes. Phylogenetic analysis of the obtained sequences has significantly expanded the known diversity of these monoxenous parasites. Fifteen typing units were found among these isolates including 11 potentially new species. Four typing units matched the previously known typing units from the Neotropics indicating a global distribution of the respective parasite species. At the same time, new clades appeared, testifying for a certain level of endemism. The host record of the parasites found indicated a variable specificity level of the host-parasite association including several cases of a very broad host range. Our results disprove the "one host - one parasite" paradigm and show that although the global diversity of monoxenous parasites is high, it is not as enormous as suggested earlier. Moreover, phylogenetic analysis revealed the presence, among the isolated strains, of a new Phytomonas species, which is the first documentation of this potentially pathogenic dixenous parasite of plants in China. |
| PMID: 19835965 [PubMed - indexed for MEDLINE] | |
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