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Sent on Tuesday, 2010 Feb 02Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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| PubMed Results |
| 1. | Eur J Med Chem. 2010 Jan 14. [Epub ahead of print]Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma.Graebin CS, Madeira MD, Yokoyama-Yasunaka JK, Miguel DC, Uliana SR, Benitez D, Cerecetto H, González M, Rosa RG, Eifler-Lima VL.Lab. de Síntese Orgânica Medicinal (LaSOM), Faculdade de Farmácia, UFRGS, Avenida Ipiranga, 2752, sala 705, 90610-000, Porto Alegre, RS, Brazil. The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives. Copyright © 2010 Elsevier Masson SAS. All rights reserved. |
| PMID: 20116908 [PubMed - as supplied by publisher] | |
| 2. | Bioorg Med Chem. 2010 Jan 7. [Epub ahead of print]Synthesis and anti-leishmanial activity of heterocyclic betulin derivatives.Alakurtti S, Heiska T, Kiriazis A, Sacerdoti-Sierra N, Jaffe CL, Yli-Kauhaluoma J.Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, PO Box 56 (Viikinkaari 5 E), FI-00014 University of Helsinki, Finland; VTT Technical Research Centre of Finland, VTT, PO Box 1000, FI-02044 VTT (Espoo), Finland. Betulin, a naturally occurring abundant triterpene is converted in four steps to 3,28-di-O-acetyllupa-12,18-diene. When various 4-substituted urazoles were oxidized to the corresponding urazines with iodobenzene diacetate in the presence of 3,28-di-O-acetyllupa-12,18-diene, new heterocyclic betulin derivatives were produced. These betulin derivatives were examined in a microplate assay at 50muM for their ability to inhibit the growth of Leishmania donovani axenic amastigotes, a species that causes the fatal visceral leishmaniasis. GI(50) (concentration for 50% growth inhibition) values of the most effective compounds were determined and their cytotoxicity on the human macrophage cell line THP-1 evaluated. The anti-leishmanial activity on L. donovani amastigotes growing in macrophages was also examined. The heterocycloadduct between 3,28-di-O-acetyllupa-12,18-diene and 4-methylurazine was the most effective derivative with an GI(50)=8.9muM against L. donovani amastigotes. Copyright © 2010 Elsevier Ltd. All rights reserved. |
| PMID: 20116263 [PubMed - as supplied by publisher] | |
| 3. | Emerg Infect Dis. 2010 Feb;16(2):354-6.Human African Trypanosomiasis in Areas without Surveillance.Chappuis F, Lima MA, Flevaud L, Ritmeijer K.Medecins sans Frontieres, Geneva, Switzerland (F. Chappuis); Geneva University Hospitals, Geneva (F. Chappuis); Medecins sans Frontieres, Barcelona, Spain (M.A. Lima, L. Flevaud); and Medecins sans Frontieres, Amsterdam, the Netherlands (K. Ritmeijer). To the Editor: Human African trypanosomiasis (HAT), sleeping sickness, is a systemic protozoan disease transmitted by the bite of a tsetse fly; untreated infection is fatal (1). Control of HAT caused by Trypanosoma brucei gambiense, which caused 97% of all cases reported from 1997 through 2006 (2), is based on active screening of the population at risk by mobile teams and treatment of all infected persons, with or without vector control. |
| PMID: 20113585 [PubMed - in process] | |
| 4. | Emerg Infect Dis. 2010 Feb;16(2):231-237.Domestic Animals and Epidemiology of Visceral Leishmaniasis, Nepal.Bhattarai NR, Van der Auwera G, Rijal S, Picado A, Speybroeck N, Khanal B, De Doncker S, Das ML, Ostyn B, Davies C, Coosemans M, Berkvens D, Boelaert M, Dujardin JC.B.P. Koirala Institute of Health Sciences, Dharan, Nepal (N.R. Bhattarai, S. Rijal, B. Khanal, M.L. Das); Institute of Tropical Medicine, Antwerp, Belgium (N.R. Bhattarai, G. Van der Auwera, N. Speybroeck, S. De Doncker, B. Ostyn, M. Coosemans, D. Berkvens, M. Boelaert, J.-C. Dujardin); London School of Hygiene and Tropical Medicine, London, UK (A. Picado, C. Davies); Universite Catholique de Louvain, Brussels, Belgium (N.R. Bhattarai); University of Antwerp, Antwerp (M. Coosemans, J.-C. Dujardin); and Prins Leopold Institute, Antwerp (J.-C. Dujardin). On the Indian subcontinent, visceral leishmaniasis (VL) is considered an anthroponosis. To determine possible reasons for its persistence during interepidemic periods, we mapped Leishmania infections among healthy persons and animals in an area of active VL transmission in Nepal. During 4 months (September 2007-February 2008), blood was collected from persons, goats, cows, and buffaloes in 1 village. Leishmania infections were determined by using PCR. We found infections among persons (6.1%), cows (5%), buffaloes (4%), and goats (16%). Data were georeferenced and entered into a geographic information system. The bivariate K-function results indicated spatial clustering of Leishmania spp.-positive persons and domestic animals. Classification tree analysis determined that among several possible risk factors for Leishmania infection among persons, proximity of Leishmania spp.-positive goats ranked first. Although our data do not necessarily mean that goats constitute a reservoir host of L. donovani, these observations indicate the need for further investigation of goats' possible role in VL transmission. |
| PMID: 20113552 [PubMed - as supplied by publisher] | |
| 5. | J Eukaryot Microbiol. 2010 Jan 22. [Epub ahead of print]Two New Species of Trypanosomatid Parasites Isolated from Heteroptera in Costa Rica.Maslov DA, Yurchenko VY, Jirků M, Lukeš J.Department of Biology, University of California, Riverside, CA 92521, USA. ABSTRACT. Two new trypanosomatid species (Euglenozoa, Kinetoplastea) isolated from the intestinal tract of heteropteran insect hosts were described based on molecular phylogenetic analyses of Spliced Leader (SL) RNA gene repeats, glycosomal glyceraldehyde phosphate dehydrogenase, and small subunit ribosomal RNA genes, as well as by morphology. Leptomonas barvae n. sp., from a mirid host Collaria oleosa, was found to represent one of the closest monoxenous (one host) relatives of the dixenous (two hosts) parasitic genus Leishmania. This finding further supports the origin of these dixenous parasites from monoxenous progenitors in the Neotropics. Blastocrithidia largi n. sp., from a largid host Largus cinctus, is among a few members of this genus available in culture. The species is a close relative of Blastocrithidia triatomae and is a member of a new monophyletic phylogenetic group characterized by formation of straphanger cysts. |
| PMID: 20113381 [PubMed - as supplied by publisher] | |
| 6. | Antimicrob Agents Chemother. 2009 Dec;53(12):5074-9. Epub 2009 Sep 28.In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model.Gillingwater K, Kumar A, Anbazhagan M, Boykin DW, Tidwell RR, Brun R.Parasite Chemotherapy, Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland. Surra is an animal pathogenic protozoan infection, caused by Trypanosoma evansi, that develops into a fatal wasting disease. Control measures rely on diagnosis and treatment. However, with the continuous emergence of drug resistance, this tactic is failing, and the pressing need for new chemotherapeutic agents is becoming critical. With the introduction of novel aromatic diamidines, a new category of antitrypanosomal drugs was discovered. Nevertheless, their efficacy within a T. evansi-infected mouse model was not known. In total, 30 compounds previously selected based on their in vitro activity were tested in a T. evansi mouse model of infection. Six of the compounds were capable of curing T. evansi-infected mice at drug doses as low as 0.5 and 0.25 mg/kg of body weight administered for 4 consecutive days, and they were more effective than the standard drugs suramin, diminazene, and quinapyramine. After all selection criteria were applied, three diamidine compounds (DB 75, DB 867, and DB 1192) qualified as lead compounds and were considered to have the potential to act as preclinical candidates against T. evansi infection. PMCID: PMC2786327 [Available on 2010/6/1] |
| PMID: 19786604 [PubMed - indexed for MEDLINE] | |
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| 7. | J Invertebr Pathol. 2009 Nov;102(3):263-5. Epub 2009 Aug 12.Invasive Bombus terrestris (Hymenoptera: Apidae) parasitized by a flagellate (Euglenozoa: Kinetoplastea) and a neogregarine (Apicomplexa: Neogrega rinorida).Plischuk S, Lange CE.Centro de Estudios Parasitológicos y de Vectores (CEPAVE), CCT La Plata CONICET-UNLP and Comisión de Investigaciones Científicas (CIC) de la provincia de Buenos Aires, Calle 2 # 584, La Plata 1900, Argentina. The flagellate Crithidia bombi and the neogregarine Apicystis bombi have been found in individuals of Bombus terrestris, a Palaearctic species of bumble bee commercially reared and shipped worldwide for pollination services. B. terrestris has recently entered into the northwestern Patagonia region of Argentina from Chile, where it was introduced in 1998. Prevalence was 21.6% for C. bombi and 3.6% for A. bombi (n=111). The pathogens were not detected in 441 bumble bees belonging to five of the eight known Argentine native species (Bombus atratus, Bombus morio, Bombus bellicosus, Bombus opifex, Bombus tucumanus) collected elsewhere in the country. Although the absence of natural occurrence of C. bombi and A. bombi in Argentine native bumble bees cannot be ascertained at present due to the limited surveys performed, it is important to report their detection in invasive B. terrestris. The invasion event is relatively recent and the accompanying pathogens are not species specific within the genus Bombus. |
| PMID: 19682459 [PubMed - indexed for MEDLINE] | |
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| 8. | Microbes Infect. 2009 Nov;11(13):1037-45. Epub 2009 Aug 4.Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease.Marinho CR, Nuñez-Apaza LN, Bortoluci KR, Bombeiro AL, Bucci DZ, Grisotto MG, Sardinha LR, Jorquera CE, Lira S, Lima MR, Alvarez JM.Department of Immunology, Biomedical Sciences Institute, University of São Paulo, Av. Professor Lineu Prestes, 1730, São Paulo, SP, CEP-05508-000, Brazil. The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity. This report reviews our studies with Sylvio X10/4 parasites, a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to chronic myocarditis resembling the human disease. |
| PMID: 19660570 [PubMed - indexed for MEDLINE] | |
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| 9. | J Invertebr Pathol. 2009 Nov;102(3):233-7. Epub 2009 Aug 4.Prevalence and distribution of parasites and pathogens of triatominae from Argentina, with emphasis on Triatoma infestans and Triatoma virus TrV.Marti GA, Echeverria MG, Susevich ML, Becnel JJ, Pelizza SA, García JJ.Centro Regional de Investigaciones Científicas y Transferencias Tecnológicas (CRILAR) (CONICET), La Rioja, Argentina. gmarti@cepave.edu.ar Chagas' disease is the most important endemic arthropod-zoonosis in Argentina with an estimated 1.6 million people infected with the causative agent Trypanosoma cruzi. Triatoma infestans is the main vector of Chagas' disease in Argentina. A survey for parasites and pathogens of Triatominae was conducted from August 2002 to February 2005. Collections of insects were made in domiciles, peridomiciles, and in the natural habitats of the Triatominae. Insects from these collections were dissected and their organs and tissues examined for flagellates. Frass from these insects was collected and examined for detection of the entomopathogenic virus Triatoma virus (TrV) using AC-ELISA and PCR. Triatominae belonging to four species, T. infestans (n=1646), Triatoma guasayana (n=4), Triatoma platensis (n=1) and Triatoma sordida (n=5) were collected from 62 sites located in 13 provinces of Argentina. Triatoma virus and two protozoan species, Blastocrithidia triatomae and T. cruzi, the etiological agent of Chagas disease, were found infecting Triatominae. The total prevalence of TrV in 1646 T. infestans analyzed by ELISA was 9.66% (159/1646) from 7 to 13 provinces where collections were made. Triatoma virus positive triatomines were found in 17 of 62 populations when examined by AC-ELISA but in 38 of 62 populations when PCR was used for detection. The prevalence of B. triatomae in T. infestans was 0.43% (7/1646), while the prevalence of T. cruzi was 1.3% (21/1646). This is the first study on the diversity, distribution and prevalence of flagellated protozoa and TrV of Triatominae in endemic Chagas' disease regions of Argentina. |
| PMID: 19660466 [PubMed - indexed for MEDLINE] | |
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| 10. | Protist. 2009 Nov;160(4):481-2. Epub 2009 May 29.Science is a hard mistress.Simpson L. |
| PMID: 19481973 [PubMed - indexed for MEDLINE] | |
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