What's new for 'Trypanosomatids' in PubMed

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Sent on Wednesday, 2010 Feb 03
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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1.	Molecules. 2009 Nov 10;14(11):4570-90. The trypanocidal activity of naphthoquinones: a review. Pinto AV, de Castro SL. Núcleo de Pesquisas em Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Naphthoquinones are compounds present in several families of higher plants. Their molecular structures confer redox properties, and they are involved in multiple biological oxidative processes. In folk medicine, especially among Indian populations, plants containing naphthoquinones have been employed for the treatment of various diseases. The biological redox cycle of quinones can be initiated by one electron reduction leading to the formation of semiquinones, unstable intermediates that react rapidly with molecular oxygen, generating free radicals. Alternatively, the reduction by two electrons, mediated by DT-diphorase, leads to the formation of hydroquinone. Lapachol, alpha-lapachone and beta-lapachone, which are isolated from the heartwood of trees of the Bignoniaceae family, are examples of bioactive naphthoquinones. In this review, we will discuss studies investigating the activity of these natural products and their derivatives in the context of the search for alternative drugs for Chagas disease, caused by Trypanosoma cruzi, a neglected illness that is endemic in Latin America.
	PMID: 19924086 [PubMed - indexed for MEDLINE]
	Publication Types: Research Support, Non-U.S. Gov't Review MeSH Terms: Animals Chagas Disease/drug therapy Chagas Disease/parasitology Humans Naphthoquinones/pharmacology Naphthoquinones/therapeutic use* Trypanocidal Agents/pharmacology Trypanocidal Agents/therapeutic use* Trypanosoma cruzi/drug effects Substances: Naphthoquinones Trypanocidal Agents beta-lapachone