What's new for 'Trypanosomatids' in PubMed

This message contains My NCBI what's new results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM).
Do not reply directly to this message.

Sender's message:

Sent on Friday, 2010 Aug 20
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
Click here to view complete results in PubMed. (Results may change over time.)
To unsubscribe from these e-mail updates click here.

PubMed Results

Items 1 - 8 of 8

1.	Curr Opin Investig Drugs. 2010 Aug;11(8):876-83. Diamidines for human African trypanosomiasis. Paine MF, Wang MZ, Generaux CN, Boykin DW, Wilson WD, De Koning HP, Olson CA, Pohlig G, Burri C, Brun R, Murilla GA. University of Glasgow, Wellcome Trust Centre for Molecular and Biochemical Parasitology, Institute of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, Glasgow, G12 8TA, UK. m.barrett@bio.gla.ac.uk. Abstract Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active against first-stage HAT only, prior to the parasites causing neurological deterioration through invasion of the CNS. A major research effort to design novel diamidines has led to the development of orally active prodrugs and, remarkably, a new generation of compounds that can penetrate the CNS. In this review, progress in the development of diamidines for the treatment of HAT is discussed.
	PMID: 20721830 [PubMed - in process]
	Related citations

2.	Curr Opin Investig Drugs. 2010 Aug;11(8):868-75. Antimicrobial peptides for leishmaniasis. Cobb SL, Denny PW. Durham University, Biophysical Sciences Institute, Centre for Bioactive Chemistry, Department of Chemistry and School of Biological and Biomedical Sciences, University Science Laboratories, South Road, Durham, DH1 3LE, UK. s.l.cobb@durham.ac.uk. Abstract Leishmaniasis is a parasitic disease that is endemic to American, African, Asian and southern European countries. More than 350 million individuals in 88 countries are at risk of infection from this neglected tropical disease. No effective vaccinations are available against leishmaniasis, and control of the disease relies entirely on toxic drug treatments, some of which were developed as early as the 1940s. As parasite resistance becomes more prevalent, there is increasing concern that currently used drugs will soon become ineffective treatments. Consequently, an urgent need exists to develop new classes of compounds that are active against drug-resistant strains of Leishmania. This review summarizes research aimed at investigating the potential development of antimicrobial peptide-based antileishmanial agents.
	PMID: 20721829 [PubMed - in process]
	Related citations

3.	J Clin Microbiol. 2010 Aug 18. [Epub ahead of print] Use of FTA Cards for Direct Sampli ng of Patients' Lesions in the Ecological Study of Cutaneous Leishmaniasis. Kato H, Cáceres AG, Mimori T, Ishimaru Y, Sayed AS, Fujita M, Iwata H, Uezato H, Velez LN, Gomez EA, Hashiguchi Y. Department of Veterinary Hygiene, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan; Sección de Entomología, Instituto de Medicina Tropical "Daniel A. Carrion", Facultad de Medicina, Universidad Nacional Mayor de San Marcos, and Laboratorio de Entomología, Instituto Nacional de Salud, Lima, Perú; Department of Microbiology, School of Health Sciences, Kumamoto University, Kumamoto, Japan; Department of Animal Hygiene and Zoonoses, Faculty of Veterinary Medicine, Assiut University, Egypt; Department of Dermatology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan; Programa de Leishmaniasis and Programa de Oncocercosis, Servicio Nacional de Erradicacion de la Malaria (SNEM), Ministerio de Salud Publica, Ecuador; and Department of Parasitology, Kochi Medical School, Kochi University, Kochi, Japan. Abstract FTA card (Whatman) was assessed for the utility as a molecular epidemiological tool in sample collections from patients with leishmaniasis in Peru since the card has a variety of merits; less invasive for the patients and easy handling for both physicians and other medical personnel at sample collection or diagnosis, in addition to its simplicity and easy countrywide and/or inter-countrywide transportation for the analysis. Samples were collected from 132 patients suspected of having leishmaniasis, and Leishmania species were successfully identified in samples from 81 patients in 15 departments of Peru by cytochrome b and mannose phosphate isomerase gene analyses. Of these, 61.7 % were identified as Leishmania (Viannia) peruviana, 22.2 % was L. (V.) braziliensis, 12.3 % was L. (V.) guyanensis, 2.5 % was L. (V.) shawi, and 1.2 % was L. (V.) lainsoni. The three dominant species, L. (V.) peruviana, L. (V.) braziliensis and L. (V.) guyanensis, were mainly found in the Andean highlands, in the tropical rainforest, and in northern and central rainforest regions, respectively. This is the first time L. (V.) shawi has been identified outside of Brazil. The present study showed that FTA card will be a useful tool for the ecological study of different forms of leishmaniasis. Further, sampling collection directly from patients' lesions by using FTA card eliminates 1) the possibility of contamination of Leishmania isolates, during short and/or long term passages of culture in vitro in each laboratory, and 2) the painfulness and suffering of patients by taking samples of skin biopsy.
	PMID: 20720027 [PubMed - as supplied by publisher]
	Related citations

4.	Micron. 2010 Jul 27. [Epub ahead of print] Visualization of the flagellar surface of protists by atomic force microscopy. Rocha GM, Miranda K, Weissmüller G, Bisch PM, de Souza W. Laboratório de Ultraestrutura Celular Hertha Meyer, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco G subsolo, Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21941-902, Brazil; Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagens, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco G subsolo, Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21941-902, Brazil; Diretoria de Programa, Instituto Nacional de Metrologia, Normalização e Qualidade Industrial - Inmetro, Av. Nossa Senhora das Graças, 50, Duque de Caxias, Rio de Janeiro 25250-020, Brazil. Abstract In many cells, motility is mediated by flagellar beating. Protist parasites are capable of highly coordinated motility which contributes to their pathogenicity in mammalian hosts. Understanding the structural aspects of the flagellum may be important to the identification of novel targets for therapeutic intervention. Our group used atomic force microscopy (AFM) to examine the ultrastructure of Trypanosoma cruzi, obtaining valuable information on the organisation of the flagellar sub-structure. AFM images revealed novel flagellar components such as the presence of periodically-spaced protrusions organised along a flagellar furrow and oriented through the major flagellar axis between the axoneme and the paraflagellar rod. The nature and functional role of this structure are still unknown, although the hypothesis that the furrow might physically separate the two distinct domains of the flagellar membrane that comprise the surface of the axoneme and the paraflagellar rod (PFR) has been raised. To test whether the furrow was present or not only in PFR-bearing flagella, different protists containing or lacking the PFR, were analysed by AFM. Analysis of T. cruzi, Trypanosoma brucei and Herpetomonas megaseliae, which present distinct PFRs, showed similar and equivalent furrows along the main axis of their flagella, whereas Crithidia deanei, Giardia lamblia and Tritrichomonas foetus (in which the PFR is reduced or absent) lacked a furrow. Our results strongly suggest that the flagellar furrow is a characteristic feature of PFR-containing flagella and opens new perspectives for its functional role in the definition of sub-domains on the flagellar membrane.
	PMID: 20719525 [PubMed - as supplied by publisher]
	Related citations

5.	Bioorg Med Chem Lett. 2010 Jul 22. [Epub ahead of print] Design and synthesis of new adamantyl-substituted antileishmanial ether phospholipids. Papanastasiou I, Prousis KC, Georgikopoulou K, Pavlidis T, Scoulica E, Kolocouris N, Calogeropoulou T. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, Athens 15771, Greece. Abstract A series of new 2-[3-(2-alkyloxy-ethyl)-adamantan-1-yl]-ethoxy substituted ether phospholipids was synthesized and their antileishmanial activity was evaluated against Leishmania infantum amastigotes. The majority of the new analogues were significantly less cytotoxic than miltefosine while, antiparasitic activity depended on the length of the 2-alkyloxy substituent. The most potent compounds were {2-[[[3-(2-hexyloxy-ethyl)-adamant-1-yl]-ethoxy]hydroxyphosphinyloxy]ethyl}-Nu,Nu,Nu-trimethyl-ammonium inner salt (5b) and {2-[[[3-(2-octyloxy-ethyl)-adamant-1-yl]-ethoxy]hydroxyphosphinyloxy]ethyl}-Nu,Nu,Nu-trimethyl-ammonium inner salt (5c).
	PMID: 20719503 [PubMed - as supplied by publisher]
	Related citations

6.	Adv Exp Med Biol. 2010;673:200-11. Modelling the transmission of Trypanosoma cruzi: the need for an integrated genetic epidemiological and population genomics approach. Tibayrenc M. Genetics and Evolution of Infectious Diseases, IRD, BP 64501, 34394 Montpellier Cedex 5, France. michel.tibayrenc@ird.fr Abstract This chapter describes what should be an integrated approach to the genetic epidemiology and population genomics of Chagas disease. Many studies have been conducted on the genetic diversity of Trypanosoma cruzi and the various triatomine bug species able to transmit Chagas disease. Far less research has analyzed the role played by the host's genetic variability on the transmission and severity of the disease. An integrated genetic epidemiology/population genomics approach would analyze these three components of the transmission chain together as well as their possible interactions (co-evolution phenomena). This is facilitated by the recent impressive progress in mega biotechnologies and by the fact that Chagas disease is an ideal model for experimental evolution approaches.
	PMID: 20632539 [PubMed - indexed for MEDLINE]
	Related citations

7.	Biochim Biophys Acta. 2010 Aug;1804(8):1591-603. Epub 2010 Feb 2. Sirtuin chemical mechanisms. Sauve AA. Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10065, USA. aas2004@med.cornell.edu Abstract Sirtuins are ancient proteins widely distributed in all lifeforms of earth. These proteins are universally able to bind NAD(+), and activate it to effect ADP-ribosylation of cellular nucleophiles. The most commonly observed sirtuin reaction is the ADP-ribosylation of acetyllysine, which leads to NAD(+)-dependent deacetylation. Other types of ADP-ribosylation have also been observed, including protein ADP-ribosylation, NAD(+) solvolysis and ADP-ribosyltransfer to 5,6-dimethylbenzimidazole, a reaction involved in eubacterial cobalamin biosynthesis. This review broadly surveys the chemistries and chemical mechanisms of these enzymes. PMCID: PMC2886189 [Available on 2011/8/1]
	PMID: 20132909 [PubMed - indexed for MEDLINE]
	Related citations

8.	Res Vet Sci. 2010 Jun;88(3):470-7. Epub 2009 Dec 30. Prevalence and incidence of bovine trypanosomosis in an agro-pastoral area of sout hwestern Burkina Faso. Dayo GK, Bengaly Z, Messad S, Bucheton B, Sidibe I, Cene B, Cuny G, Thevenon S. IRD, UMR Trypanosomes, TA A-17/A Campus International de Baillarguet, 34398 Montpellier Cedex 5, France. Abstract The present study was conducted to determine the prevalence and incidence of trypanosomosis and to investigate some factors influencing them in an agro-pastoral area of southwestern Burkina Faso. A total of 363 crossbred cattle (Baoule-zebu peul), which were bred under natural trypanosomosis challenge, were monitored monthly for parasitaemia, packed cell volume (PCV) and serological analyses over 2years. The parasitological prevalence estimated at the beginning of the survey using the buffy coat technique (BCT) was 7.54%. As much as 66.7% of all trypanosome infections were due to Trypanosoma vivax, 23.8% due to Trypanosoma congolense and 9.5% due to T. vivax/T. congolense mixed infections. The monthly serological incidence varied from 0.29% to 19.29%. The season was the most important factor influencing the serological prevalence and incidence and the animal PCV. The dry hot season is associated with increasing seroprevalences and incidences and consequently a decreasing average of PCV. In addition, an important spatial heterogeneity was observed.
	PMID: 20044115 [PubMed - indexed for MEDLINE]
	Related citations