What's new for 'Trypanosomatids' in PubMed

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Sent on Thursday, 2011 Sep 08
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results

Items 1 - 4 of 4

1.	Am J Trop Med Hyg. 2011 Sep;85(3):535-9. Adipose tissue-derived mesenchymal stem cells as a new host cell in latent leishmaniasis. Allahverdiyev AM, Bagirova M, Elcicek S, Koc RC, Baydar SY, Findikli N, Oztel ON. Source Department of Bioengineering, Yildiz Technical University, Istanbul, Turkey; Department of Bioengineering, Firat University, Elazig, Turkey. Abstract Abstract. Some protozoan infections such as Toxoplasma, Cryptosporidium, and Plasmodium can be transmitted through stem cell transplantations. To our knowledge, so far, there is no study about transmission of Leishmania parasites in stem cell transplantation and interactions between parasites and stem cells in vitro. Therefore, the aim of this study was to investigate the interaction between different species of Leishmania parasites and adipose tissue-derived mesenchymal stem cells (ADMSCs). ADMSCs have been isolated, cultured, characterized, and infected with different species of Leishmania parasites (L. donovani, L. major, L. tropica, and L. infantum). Infectivity was examined by Giemsa staining, microculture, and polymerase chain reaction methods. As a result, infectivity of ADMSCs by Leishmania parasites has been determined for the first time in this study. According to our findings, it is very important that donors are screened for Leishmania parasites before stem cell transplantations in regions where leishmaniasis is endemic.
	PMID: 21896818 [PubMed - in process]

2.	Am J Trop Med Hyg. 2011 Sep;85(3):528-34. Economic consequences of post-kala-azar dermal leishmaniasis in a rural bangladeshi community. Ozaki M, Islam S, Rahman KM, Rahman A, Luby SP, Bern C. Source Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Children's Hospital and Research Center Oakland, Oakland, California; International Center for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia. Abstract Abstract. Post-kala-azar dermal leishmaniasis (PKDL) is a complication of visceral leishmaniasis. Bangladesh national treatment guidelines during the study period called for 120 intramuscular injections of sodium antimony gluconate (SAG). We assessed care-seeking behavior, diagnosis and treatment costs, and coping strategies among 134 PKDL patients; 56 (42%) patients had been treated with SAG, and 78 (58%) remained untreated. The median direct cost per patient treated was US$367 (interquartile range [IQR] = 90-284), more than two times the estimated per capita annual income for the study population. The most common coping strategy was to take a loan; the median amount borrowed was US$98 (IQR = 71-150), with a median interest of US$32 (IQR = 16-95). Households lost a median of 123 work-days per patient treated. The current regimen for PKDL imposes a significant financial burden, reinforcing the link between poverty and visceral leishmaniasis. More practical shorter-course regimens for PKDL are urgently needed to achieve national and regional visceral leishmaniasis elimination goals.
	PMID: 21896817 [PubMed - in process]

3.	Am J Trop Med Hyg. 2011 Sep;85(3):524-7. American Tegumentary Leishmaniasis and HIV-AIDS Association in a Tertiary Care Center in the Brazilian Amazon. Guerra JA, Coelho LI, Pereira FR, Siqueira AM, Ribeiro RL, Almeida TM, Lacerda MV, Barbosa MG, Talhari S. Source Gerência de Leishmaniose, Gerência de DST e AIDS, Gerência de Malária, Gerência de Entomologia e Gerência de Dermatologia Tropical, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil. Abstract Abstract. American tegumentary leishmaniasis (ATL) and human immunodeficiency virus (HIV) are both common infectious diseases in the Brazilian Amazon with overlapping expansion areas, which leads to the occurrence of Leishmania/HIV coinfection. Most ATL/HIV-acquired immunodeficiency syndrome (AIDS) association cases have been reported from areas where Leishmania (Viannia) braziliensis is the main pathogen; this finding is in contrast with the Amazon region, where L. (V.) guyanensis is the most implicated agent, implying distinct clinical and therapeutic aspects. We describe 15 cases of ATL/HIV coinfection treated in a tertiary care center in the Brazilian Amazon between 1999 and 2008. Thirteen patients presented with diverse clinical manifestations of cutaneous leishmaniasis, and four of them had disseminated forms; two patients presented with mucosal leishmaniasis (ML). Seven patients required more than one course of treatment. The particularities of ATL/HIV-AIDS association in L. (V.) guyanensis-endemic areas require efforts for an increased understanding of its burden and subsequent improvements in case management.
	PMID: 21896816 [PubMed - in process]

4.	Gastroenterology. 2011 Jul;141(1):35-404. Epub 2011 Jun 1. Megacolon from Chagas disease in an ancient Texan. Diagnosis: Chagas disease causing mega-disease, in this case megacolon. Barth E, Kundrotas L. Source Lackland AFB, San Antonio, Texas, USA.
	PMID: 21640110 [PubMed - indexed for MEDLINE]
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