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Sent on Friday, 2012 February 10Search: kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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| PubMed Results |
| 1. | Parasit Vectors. 2012 Feb 9;5(1):31. [Epub ahead of print]Current epidemiological profile and features of visceral leishmaniasis in People's Republic of China.Wang JY, Cui G, Chen HT, Zhou XN, Gao CH, Yang YT.AbstractABSTRACT: BACKGROUND:Visceral leishmaniasis (VL) is still an important public health problem in China. In recent years endemic regions spread, prevalence increased, and even an outbreak of the disease occurred in China due to global warming and population movement. It is essential to elucidate the current epidemic situation and epidemiological characteristics of VL for designing control policy. In the present study we describe the current epidemiological profile and characteristics of VL in China based on retrospectively reviewing of VL cases reported between 2005 and 2010 by a passive surveillance system. METHODS:The present study was a retrospective review of VL cases notified between 2005 and 2010 based on the passive surveillance data. The data were tabulated, diagrammatized and analyzed through descriptive statistics in a Microsoft Excel spreadsheet. RESULTS:A total of 2450 VL cases were notified, with a mean of 408 cases per year. 61 counties were identified as endemic area with 2224 autochthonous cases, and the other 118 counties as non-endemic areas with 226 imported cases. 97.71% of cases were concentrated in Xinjiang, Gansu and Sichuan Provinces. 9 major counties reported a mean of 10 cases per year, with a total of 1759 cases reported. Different types of VL revealed distinct epidemiological characteristics. CONCLUSIONS:The number of VL cases and endemic counties both increased in the period 2005-2010 in China. Different type or sub-type of VL revealed distinct epidemiological characteristics. Therefore, differential control measures must be taken in different endemic areas against incidence increase and endemic area spread. |
| 2. | Vet Res. 2012 Feb 8;43(1):10. [Epub ahead of print]Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice.Silva-Almeida M, Carvalho LO, Abreu-Silva AL, Souza CS, Hardoim DJ, Calabrese KS.AbstractABSTRACT: Leishmania is inoculated, by the bite of an infected sandfly, into the skin of the host, where the promastigotes are phagocyted by dermal macrophages. The dermal region comprises cells and abundant extracellular matrix. Studies show that matrix metalloproteinases play an important role in host defense responses against pathogens in mammals and that their activities lead to the production of antimicrobial peptides. The aim of this study is to evaluate the changes in the distribution of fibronectin and laminin as well as in the elastic system fibres during the course of infection caused by Leishmania amazonensis in mice with distinct genetic backgrounds of susceptibility to this parasite. The results showed that BALB/c presented an enhancement of fibronectin during the course of infection when compared to their control group while the infected or non-infected C3H.He showed a decrease of this protein at end of the experiment. Laminin, on the other hand, remained unaltered in both strains. Also in both BALB/c and C3H.He mice the elastic and elaunin fibres remained unchanged while the oxytalan fibres decreased along the experiment. Ninety days after the infection C3H.He mice had recovered their capacity to produce oxytalan fibres. |
| 3. | Adv Exp Med Biol. 2012;710:59-70.Ecological niche modeling as a tool for understanding distributions and interactions of vectors, hosts, and etiologic agents of Chagas disease.Costa J, Peterson AT.SourceLaboratório de Biodiversidade Entomológica, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil. jcosta@ioc.fiocruz.br AbstractChagas disease, or American Trypanosomiasis, is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is in turn transmitted by blood-sucking insects of the subfamily Triatominae (family Reduviidae). Because no drugs or vaccines are available to cure Chagas disease in its chronic phase, vectorial control (i.e., insecticide spraying) constitutes the principal means by which to impair Chagas disease transmission. Environmental and social factors have caused changes in the epidemiology of this disease-it was originally restricted to Latin America, but is now becoming a global heath concern in non-endemic areas as a consequence of human migrations. In Brazil, despite the fact that the most effective vector has been controlled, other triatomine species infest and colonize domiciliary habitats and can transmit the pathogen. As a consequence, Chagas disease transmission continues: the prevalence of the disease remains at ∼12 million people, with ∼200,000 new cases per year in 15 countries of Latin America, making control actions still necessary. Understanding the environmental requirements and geographic distributions of vectors is key to guiding control measures, and understanding better epidemiologic aspects of the disease. Ecologic niche modeling is a relatively new tool that permits such insights--as a consequence, here, we present an overview of insights gained using this approach in understanding of Chagas disease. |
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| 4. | Med Microbiol Immunol. 2011 Nov;200(4):209-18. Epub 2011 Mar 24.Trypanosoma cruzi antigen immunization induces a higher B cell survival in BALB/c mi ce, a susceptible strain, compared to C57BL/6 B lymphocytes, a resistant strain to cardiac autoimmunity.Pellegrini A, Carrera-Silva EA, Arocena A, Cano RC, Aoki MP, Gea S.SourceInmunología, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, CIBICI-CONICET, Universidad Nacional de Córdoba, Ciudad Universitaria, Haya de la Torre y Medina Allende S/N, 5000 Córdoba, Argentina. apellegrini@fcq.unc.edu.ar AbstractChagas disease, caused by Trypanosoma cruzi, is endemic in Latin America and represents the most common infectious myocarditis worldwide. Autoimmunity is one of the mechanisms contributing to its pathogenesis. Although the cellular interactions that promote this autoimmune response are still poorly understood, several studies have demonstrated a key role for B lymphocytes since they secrete antibodies, cytokines and present antigens. Recently, we reported that immunization with cruzipain, an immunodominant T. cruzi antigen, induces a higher activation state in B cells from BALB/c mice (susceptible to cardiac autoimmunity) than B lymphocytes from C57BL/6 (a resistant strain). Here, we focused on the study of B cell survival in both mouse strains after cruzipain immunization and demonstrated an increased survival rate of B cells from BALB/c compared to C57BL/6 mice. This phenomenon was associated with a decreased expression of Fas/FasL and an increased expression of anti-apoptotic Bcl-2/Bcl-xL proteins. With the purpose to gain more knowledge about the mechanisms involved, we found that IL-4 produced by BALB/c B cells played a key role in the survival in an autocrine way whereas the addition of this bioactive cytokine rescued C57BL/6 B lymphocytes from apoptosis. Our findings suggest that in the absence of infection, both enhanced B cell activation induced by the immunization with a single parasite antigen and insufficient negative regulation can potentially contribute to autoimmunity seen in cruzipain immune BALB/c mice. © Springer-Verlag 2011 |
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