What's new for 'Trypanosomatids' in PubMed

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Sent on Thursday, 2010 Apr 29
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results

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1.	J Nat Prod. 2010 Apr 27. [Epub ahead of print] Coumarins from Galipea panamensis and Their Activity against Leishmania panamensis. Arango V, Robledo S, Séon-Méniel B, Figadère B, Cardona W, Sáez J, Otálvaro F. Instituto de Quimica, Quimica de Plantas Colombianas, Universidad de Antioquia, A.A 1226, Medellin, Colombia, Programa de Estudio y Control de Enfermedades Tropicales (PECET), Universidad de Antioquia, A.A 1226, Medellin, Colombia, Laboratoire de Pharmacognosie, Associe au CNRS (BIOCIS), Universite de Paris-Sud, F-92296, Chatenay-Malabry, France, and Instituto de Quimica, Sintesis y Biosintesis de Metabolitos Naturales, Universidad de Antioquia, A.A 1226, Medellin, Colombia. Abstract Two new coumarin compounds (1 and 2), phebalosin (3), its derived artifact murralongin (4), and murrangatin acetonide (5) were isolated from the leaves of Galipea panamensis. The structures of 1 and 2 were assigned as 7-{[(2R*)-3,3-dimethyloxiran-2-yl]methoxy}-8-[(2R*,3R*)-3-isopropenyloxiran-2-yl]-2H-chromen-2-one and 7-methoxy-8-(4-methyl-3-furyl)-2H-chromen-2-one, respectively, on the basis of their spectroscopic data (primarily NMR and MS). Compounds 1-3 were tested against axenic amastigote forms of Leishmania panamensis and displayed 50% effective concentrations (EC(50)) of 9.9, 10.5, and 14.1 mug/mL, respectively. These three compounds also displayed cytotoxicity (IC(50)) at concentrations of 9.7, 33.0, and 20.7 mug/mL, respectively, on human promonocytic U-937 cells.
	PMID: 20423106 [PubMed - as supplied by publisher]