What's new for 'Trypanosomatids' in PubMed

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Sent on Friday, 2011 Mar 25
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results

Items 1 - 3 of 3

1.	Planta Med. 2011 Mar 22. [Epub ahead of print] Plant Extracts, Isolated Phytochemicals, and Plant-Derived Agents Which Are Lethal to Arthropod Vectors of Human Tropical Diseases - A Review. Pohlit AM, Rezende AR, Lopes Baldin EL, Lopes NP, de Andrade Neto VF. Instituto Nacional de Pesquisa da Amazônia, Manaus, Amazonas State, Brazil. Abstract The recent scientific literature on plant-derived agents with potential or effective use in the control of the arthropod vectors of human tropical diseases is reviewed. Arthropod-borne tropical diseases include: amebiasis, Chagas disease (American trypanosomiasis), cholera, cryptosporidiosis, dengue (hemorrhagic fever), epidemic typhus (Brill-Zinsser disease), filariasis (elephantiasis), giardia (giardiasis), human African trypanosomiasis (sleeping sickness), isosporiasis, leishmaniasis, Lyme disease (lyme borreliosis), malaria, onchocerciasis, plague, recurrent fever, sarcocystosis, scabies (mites as causal agents), spotted fever, toxoplasmosis, West Nile fever, and yellow fever. Thus, coverage was given to work describing plant-derived extracts, essential oils (EOs), and isolated chemicals with toxic or noxious effects on filth bugs (mechanical vectors), such as common houseflies ( MUSCA DOMESTICA Linnaeus), American and German cockroaches ( PERIPLANETA AMERICANA Linnaeus, BLATELLA GERMANICA Linnaeus), and oriental latrine/blowflies ( CHRYSOMYA MEGACEPHALA Fabricius) as well as biting, blood-sucking arthropods such as blackflies ( SIMULIUM Latreille spp.), fleas ( XENOPSYLLA CHEOPIS Rothschild), kissing bugs ( RHODNIUS Stål spp., TRIATOMA INFESTANS Klug), body and head lice ( PEDICULUS HUMANUS HUMANUS Linnaeus, P. HUMANUS CAPITIS De Geer), mosquitoes ( AEDES Meigen, ANOPHELES Meigen, CULEX L., and OCHLEROTATUS Lynch Arribálzaga spp.), sandflies ( LUTZOMYIA LONGIPALPIS Lutz & Neiva, PHLEBOTOMUS Loew spp.), scabies mites ( SARCOPTES SCABIEI De Geer, S. SCABIEI var HOMINIS, S. SCABIEI var CANIS, S. SCABIEI var SUIS), and ticks ( IXODES Latreille, AMBLYOMMA Koch, DERMACENTOR Koch, and RHIPICEPHALUS Koch spp.). Examples of plant extracts, EOs, and isolated chemicals exhibiting noxious or toxic activity comparable or superior to the synthetic control agents of choice (pyrethroids, organophosphorous compounds, etc.) are provided in the text for many arthropod-vectors of tropical diseases. SUPPORTING INFORMATION available online at http://www.thieme-connect.de/ejournals/toc/plantamedica. © Georg Thieme Verlag KG Stuttgart · New York.
	PMID: 21432748 [PubMed - as supplied by publisher]
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2.	Expert Opin Ther Pat. 2011 Mar 24. [Epub ahead of print] Novel compounds to combat trypanosomatid inf ections: a medicinal chemical perspective. González M, Cerecetto H. Grupo de Química Medicinal, Laboratorio de Química Orgánica-Instituto de Química Biológica-Facultad de Ciencias, Universidad de la República/Iguá 4225, Montevideo 11400, Uruguay megonzal@fq.edu.uy. Abstract Introduction: The current therapeutic arsenal against the kinetoplastids Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. is clearly inadequate and underscores the urgent need to develop new effective, safe and cost-effective drugs. Areas covered: Accordingly, this review of patented products and processes using anti-kinetoplastid agents provides insight into the identification of novel or more refined drugs. In this review, we describe products developed in recent years for the treatment of human African trypanosomiasis, American trypanosomiasis and leishmaniasis from a medicinal chemical perspective. Expert opinion: Applications so far have looked only superficially for candidate anti-trypanosomatid drugs and are deficient in the final stages of drug development studies, i.e., tolerance/safety, selectivity, drug-resistance, scaling-up, pharmacokinetic and pharmacodynamic assays. The ultimate goal for production of agents with anti-HAT activity has been the development of dicationic agents with parasite DNA-binding activity. Another goal for control of human African trypanosomiasis as well as for Chagas disease and leishmaniasis is the development of protease inhibitors. It should also be noted that several recent studies describing promising targets and compounds have not yet been patented. An effort should be made by foundations, international health organizations and pharmaceutical corporations to support analysis and development of promising new chemotherapeutic agents for controlling the trypanosomiasis and leishmaniasis.
	PMID: 21428846 [PubMed - as supplied by publisher]
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3.	J Appl Microbiol. 2010 Jul;109(1):107-15. doi: 10.1111/j.1365-2672.2009.04635.x. Epub 2009 Nov 23. Multiplex PCR detection of slo wly-evolving trypanosomatids and neogregarines in bumblebees using broad-range primers. Meeus I, de Graaf DC, Jans K, Smagghe G. Laboratory of Agrozoology, Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium. Abstract AIMS: The aims of this study were to design universal markers for different protozoan parasites of Bombus spp. based on the phylogenetic position of two important bumblebee parasites Crithidia bombi and Apicystis bombi. METHODS AND RESULTS: Standard PCR and extraction techniques were used to amplify and sequence 18S rDNA. Phylogenetic analysis of the rDNA was performed in order to predict the parasite range of the primers. CONCLUSIONS: Crithidia bombi phylogenetically clusters with the trypanosomatids with slowly-evolving SSU-rRNA sequences (SE), while A. bombi is the closest sister group of Mattesia. A multiplex was designed containing an internal control and two broad-range primer pairs, detecting C. bombi and other SE trypanosomatids and also A. bombi and other neogregarines. SIGNIFICANCE AND IMPACT OF THE STUDY: Sequence data generated will further improve the current systematics of insect trypanosomatids and gregarines that remain troublesome. Broad-range markers for bumblebee parasites are necessary tools enabling the screening of commercially imported colonies and thus controlling their worldwide distribution and to discover related emerging parasites. © 2009 The Authors. Journal compilation © 2009 The Society for Applied Microbiology.
	PMID: 20015206 [PubMed - indexed for MEDLINE]
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