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Sent on Friday, 2011 May 06Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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| PubMed Results |
| 1. | Curr Genet. 2011 May 5. [Epub ahead of print]Gene fragmentation: a key to mitochondrial genome evolution in Euglenozoa?Flegontov P, Gray MW, Burger G, Lukeš J.SourceBiology Centre, Institute of Parasitology, Czech Academy of Sciences, and Faculty of Sciences, University of South Bohemia, 37005, České Budĕjovice, Czech Republic. AbstractPhylum Euglenozoa comprises three groups of eukaryotic microbes (kinetoplastids, diplonemids, and euglenids), the mitochondrial (mt) genomes of which exhibit radically different modes of organization and expression. Gene fragmentation is a striking feature of both euglenid and diplonemid mtDNAs. To rationalize the emergence of these highly divergent mtDNA types and the existence of insertion/deletion RNA editing (in kinetoplastids) and trans-splicing (in diplonemids), we propose that in the mitochondrion of the common evolutionary ancestor of Euglenozoa, small expressed gene fragments promoted a rampant neutral evolutionary pathway. Interactions between small antisense transcripts of these gene fragments and full-length transcripts, assisted by RNA-processing enzymes, permitted the emergence of RNA editing and/or trans-splicing activities, allowing the system to tolerate indel mutations and further gene fragmentation, respectively, and leading to accumulation of additional mutations. In this way, dramatically different mitochondrial genome structures and RNA-processing machineries were able to evolve. The paradigm of constructive neutral evolution acting on the widely different mitochondrial genetic systems in Euglenozoa posits the accretion of initially neutral molecular interactions by genetic drift, leading inevitably to the observed 'irremediable complexity'. |
| 2. | Trans R Soc Trop Med Hyg. 2011 May 2. [Epub ahead of print]Seroprevalence of Leishmania infantum in a rural area of Senegal: analysis of risk factors involved in transmission to humans.Faye B, Bucheton B, Bañuls AL, Senghor MW, Niang AA, Diedhiou S, Konaté O, Dione MM, Hide M, Mellul S, Knecht R, Delaunay P, Marty P, Gaye O.SourceService de Parasitologie-Mycologie, Faculté de Médecine et Pharmacie, Université Cheikh Anta Diop, BP 5005 Dakar Fann, Dakar, Senegal. AbstractWhereas Leishmania infantum, the agent of visceral leishmaniasis (VL), is well known in North Africa, very limited data exist on its spread in West Africa, where mainly cutaneous leishmaniasis has been widely reported. Nevertheless, dogs infected with L. infantum were recently found in the Mont Rolland District in Senegal. To provide a better understanding of L. infantum epidemiology in this area, clinical and serological surveys were carried out to determine the seroprevalence of L. infantum-specific antibodies in the human population. In parallel, an analysis of environmental and individual factors associated with Leishmania antigen seropositivity was conducted to identify potential risk factors for exposure. Although no cases of VL were detected within this study, a large part of the population (73/315; 23%) was exposed to infection, with a strong age effect (being >40years old increased the risk of being seropositive). Moreover, the presence of Nebedaye trees (Moringa oleifera) and infected dogs in the household were factors increasing the risk of exposure in household members. These results may provide important information to identify the still unknown sandfly species involved in transmission. Copyright © 2011 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved. |
| 3. | N Engl J Med. 2011 May 5;364(18):1773-4.Leishmania--a parasitized parasite.Scott P.SourceSchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA. |
| 4. | J Med Chem. 2011 May 4. [Epub ahead of print]Novel Lipophilic Acetohydroxamic Acid Derivatives Based on Conformationally Constrained Spiro Carbocyclic 2,6-Diketopiperazine Scaffolds with Potent Trypanocidal Activity.Fytas C, Zoidis G, Tzoutzas N, Taylor MC, Fytas G, Kelly J.AbstractWe describe novel acetohydroxamic acid derivatives with potent activity against cultured bloodstream-form Trypanosoma brucei, and selectivity indices of >1000. These analogues were derived from conformationally constrained, lipophilic, spiro carbocyclic 2,6-diketopiperazine (2,6-DKP) scaffolds by attaching acetohydroxamic acid moieties to the imidic nitrogen. Optimal activity was achieved by placing benzyl groups adjacent to the basic nitrogen of the 2,6-DKP core. S-enantiomer 2d was the most active derivative against T. brucei (IC50=6.8 nM) and T. cruzi (IC50=0.21 μΜ). |
| 5. | Trans R Soc Trop Med Hyg. 2011 Feb;105(2):115-7. Epub 2010 Dec 3.Ambisome plus miltefosine for Indian patients with kala-azar.Sundar S, Sinha PK, Verma DK, Kumar N, Alam S, Pandey K, Kumari P, Ravidas V, Chakravarty J, Verma N, Berman J, Ghalib H, Arana B.SourceKala-azar Medical Research Center, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. AbstractThe combination of one intravenous administration of 5mg/kg Ambisome and oral administration of miltefosine, 2.5mg/kg/day for 14 days, was evaluated in 135 Indian patients with kala-azar. The Intent-to-Treat cure rate at 6 months was 124 of the 135 enrolled patients (91.9%: 95% CI = 86-96%), and the per protocol cure rate was 124 of 127 evaluable patients (97.6%: 95% CI = 93-100%). Side effects could be attributed to each drug separately: fevers, rigors and back pain due to Ambisome; gastrointestinal side effects due to miltefosine. This combination is attractive for reasons of efficacy, tolerance, and feasibility of administration, although the gastrointestinal side effects of miltefosine require medical vigilance. Clinical Trials.gov identification number: NCT00371995. Copyright © 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved. |
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| 6. | Biol Res. 2010;43(2):233-41. Epub 2010 Sep 24.Sera of chagasic patients react with antigens from the tomato parasite Phytomonas serpen s.Graça-de Souza VK, Monteiro-Góes V, Manque P, Souza TA, Corrêa PR, Buck GA, Ávila AR, Yamauchi LM, Pinge-Filho P, Goldenberg S, Krieger MA, Yamada-Ogatta SF.SourceDepartamento de Microbiologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Paraná, Brazil. AbstractThe genus Phytomonas comprises trypanosomatids that can parasitize a broad range of plant species. These flagellates can cause diseases in some plant families with a wide geographic distribution, which can result in great economic losses. We have demonstrated previously that Phytomonas serpens 15T, a tomato trypanosomatid, shares antigens with Trypanosoma cruzi, the agent of human Chagas disease. Herein, two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) were used to identify proteins of P. serpens 15T that are recognized by sera from patients with Chagas disease. After 2D-electrophoresis of whole-cell lysates, 31 peptides were selected and analyzed by tandem mass spectrometry. Twenty-eight polypeptides were identified, resulting in 22 different putative proteins. The identified proteins were classified into 8 groups according to biological process, most of which were clustered into a cellular metabolic process category. These results generated a collection of proteins that can provide a starting point to obtain insights into antigenic cross reactivity among trypanosomatids and to explore P. serpens antigens as candidates for vaccine and immunologic diagnosis studies. |
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Retin A Hi nice collection but we have a problem with how to use the cu3er slides (in the first template)
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