What's new for 'Trypanosomatids' in PubMed

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Sent on Saturday, 2011 Aug 27
Search kinetoplastids OR kinetoplastid OR Kinetoplastida OR "trypanosoma brucei" OR leishmania OR brucei OR leishmaniasis OR "African trypanosomiasis"
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PubMed Results

Items 1 - 4 of 4

1.	Bioorg Med Chem Lett. 2011 Aug 5. [Epub ahead of print] Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives. Shi XL, Ge JF, Liu BQ, Kaiser M, Wittlin S, Brun R, Ihara M. Source Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, 199 Ren'Ai Road, Suzhou 215123, China. Abstract A series of 5-phenyliminobenzo[a]phenoxazine derivatives were synthesized. The in vitro antiprotozoal activities were evaluated against Plasmodium falciparum K1, Trypanosoma cruzi, Leishmania donovani and Trypanosoma brucei rhodesiense. N,N-Diethyl-5-((4-methoxyphenyl)imino)-5H-benzo[a]phenoxazin-9-amine shows IC(50)=0.040μmolL(-1) with a selective index of 1425 against Plasmodium falciparum K1. Copyright © 2011 Elsevier Ltd. All rights reserved.
	PMID: 21868222 [PubMed - as supplied by publisher]
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2.	Parasitology. 2011 Aug 26:1-6. [Epub ahead of print] Intranasal immunization with LACK-DNA promotes protective immunity in hamsters challenged with Leishmania chagasi. DE Oliveira Gomes DC, DA Silva Costa Souza BL, DE Matos Guedes HL, Lopes UG, Rossi-Bergmann B. Source Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21941-902, Rio de Janeiro, RJ, Brazil. Abstract SUMMARYLACK (Leishmania analogue of the receptor kinase C) is a conserved protein in protozoans of the genus Leishmania which is associated with the immunopathogenesis and susceptibility of BALB/c mice to L. major infection. Previously, we demonstrated that intranasal immunization with a plasmid carrying the LACK gene of Leishmania infantum (LACK-DNA) promotes protective immunity in BALB/c mice against Leishmania amazonensis and Leishmania chagasi. In the present study, we investigated the protective immunity achieved in hamsters intranasally vaccinated with 2 doses of LACK-DNA (30 μg). Compared with controls (PBS and pCI-neo plasmid), animals vaccinated with LACK-DNA showed significant reduction in parasite loads in the spleen and liver, increased lymphoproliferative response and increased nitric oxide (NO) production by parasite antigen-stimulated splenocytes. Furthermore, hamsters vaccinated with LACK-DNA presented high IgG and IgG2a serum levels when compared to control animals. Our results showed that intranasal vaccination with LACK-DNA promotes protective immune responses in hamsters and demonstrated the broad spectrum of intranasal LACK-DNA efficacy in different host species, confirming previous results in murine cutaneous and visceral leishmaniasis.
	PMID: 21867591 [PubMed - as supplied by publisher]
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3.	Vector Borne Zoonotic Dis. 2011 Aug 25. [Epub ahead of print] First Report of Natural Infection of Least Weasel (Mustela nivalis Linnaeus, 1776) with Leishmania major in Tunisia. Ghawar W, Snoussi MA, Hamida NB, Boukthir A, Yazidi R, Chaâbane S, Chemkhi J, Zâatour A, Salah AB. Source Service of Medical Epidemiology, Pasteur Institute of Tunis , 13 place Pasteur, 1003 Tunis-Belvedère, Tunisia . Abstract Abstract Zoonotic cutaneous leishmaniasis, caused by Leishmania major (L. major), is endemic in Tunisia. Several rodents have been identified as reservoir hosts of parasites. This study reports, for the first time, the natural infection with L. major zymodeme MON-25 in a specimen of least weasel: Mustela nivalis Linnaeus, 1776 (M. nivalis) collected in Sidi Bouzid. This finding justifies further research on larger samples of this animal to verify its role as a potential reservoir host for cutaneous leishmaniasis in Tunisia.
	PMID: 21867414 [PubMed - as supplied by publisher]
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4.	Parasite. 2011 May;18(2):141-4. Trapping tsetse flies on water. Laveissière C, Camara M, Rayaisse JB, Salou E, Kagbadouno M, Solano P. Source 380, route de la Virvée, 33240 Saint-Romain-la-Virvée, France. Abstract Riverine tsetse flies such as Glossina palpalis gambiensis and G. tachinoides are the vectors of human and animal trypanosomoses in West Africa. Despite intimate links between tsetse and water, to our knowledge there has never been any attempt to design trapping devices that would catch tsetse on water. In mangrove (Guinea) one challenging issue is the tide, because height above the ground for a trap is a key factor affecting tsetse catches. The trap was mounted on the remains of an old wooden dugout, and attached with rope to nearby branches, thereby allowing it to rise and fall with the tide. Catches showed a very high density of 93.9 flies/"water-trap"/day, which was significantly higher (p < 0.05) than all the catches from other habitats where the classical trap had been used. In savannah, on the Comoe river of South Burkina Faso, the biconical trap was mounted on a small wooden raft anchored to a stone, and catches were compared with the classical biconical trap put on the shores. G. p. gambiensis and G. tachinoides densities were not significantly different from those from the classical biconical one. The adaptations described here have allowed to efficiently catch tsetse on the water, which to our knowledge is reported here for the first time. This represents a great progress and opens new opportunities to undertake studies on the vectors of trypanosomoses in mangrove areas of Guinea, which are currently the areas showing the highest prevalences of sleeping sickness in West Africa. It also has huge potential for tsetse control using insecticide impregnated traps in savannah areas where traps become less efficient in rainy season. The Guinean National control programme has already expressed its willingness to use such modified traps in its control campaigns in Guinea, as has the national PATTEC programme in Burkina Faso during rainy season.
	PMID: 21678789 [PubMed - indexed for MEDLINE]
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